AMP-activated Protein Kinase (AMPK) In Acute Renal Failure
Funder
National Health and Medical Research Council
Funding Amount
$401,523.00
Summary
Acute renal failure is a common complication of any severe illness. Generally, it is the lack of blood flow, or food that leads to this problem. People who are ill are unable to provide adequate blood flow to their kidneys, so the kidneys become diseased and fail to function. This can be fatal. There are, however, mechanisms in the kidney that are designed to avoid this shortage of energy. The aim of these studies is to find out what these protective mechanisms usually do in the kidney, and unde ....Acute renal failure is a common complication of any severe illness. Generally, it is the lack of blood flow, or food that leads to this problem. People who are ill are unable to provide adequate blood flow to their kidneys, so the kidneys become diseased and fail to function. This can be fatal. There are, however, mechanisms in the kidney that are designed to avoid this shortage of energy. The aim of these studies is to find out what these protective mechanisms usually do in the kidney, and understand why they are not more active. We hope to find ways to switch them on earleir, using drugs, so as to protect the kidneys from injury.Read moreRead less
Regulation Of The Na-K-Cl Co-transporter By The AMP-activated Protein Kinase
Funder
National Health and Medical Research Council
Funding Amount
$227,036.00
Summary
The failure of the kidney to excrete enough salt is a major driving force behind high blood pressure, kidney failure and heart disease. At present, it is not known, in any detail, how the kidney is able to recognise that it is not excreting enough salt and how it changes the amount it excretes. This is important if, for example, someone eats a salty meal. Unless the kidney recognises that there is an excess of salt and adjusts itself to excrete it, then salt accumulates leading to high blood pre ....The failure of the kidney to excrete enough salt is a major driving force behind high blood pressure, kidney failure and heart disease. At present, it is not known, in any detail, how the kidney is able to recognise that it is not excreting enough salt and how it changes the amount it excretes. This is important if, for example, someone eats a salty meal. Unless the kidney recognises that there is an excess of salt and adjusts itself to excrete it, then salt accumulates leading to high blood pressure, kidney and cardiac problems. In this study, we have identified a new mechanism that the kidney uses to detect salt and to excrete it. This could be a major advance in our understanding of high blood pressure and other common diseases.Read moreRead less
Glycine Transporters regulate the concentration of glycine in the spinal cord and brain. It has been suggested that elevating glycine levels in these regions may be useful in treating pain and schizophrenia. This project will provide the basis for the development of new glycine transport inhibitors that may be used to treat these conditions.
Abalone Council Australia Ltd Management Of The National Wild Catch Abalone Research, Development And Extension Program (2024 To 2029)
Funder
Fisheries Research and Development Corporation
Funding Amount
$760,000.00
Summary
Implementing an Industry Partnership Agreement (IPA) was necessary to provide a more coordinated approach to RD&E and ensure that research funds were utilised in the more cost effective and strategic manner. It also “quarantined” funds to be overseen by the ACA for investment in Abalone specific research, giving the industry greater opportunity for input into the research that was funded and greater relevance of project outputs.
The second ACA/FRDC IPA expired in early 2024 and the AC ....Implementing an Industry Partnership Agreement (IPA) was necessary to provide a more coordinated approach to RD&E and ensure that research funds were utilised in the more cost effective and strategic manner. It also “quarantined” funds to be overseen by the ACA for investment in Abalone specific research, giving the industry greater opportunity for input into the research that was funded and greater relevance of project outputs.
The second ACA/FRDC IPA expired in early 2024 and the ACA Board and FRDC are now establishing a new IPA for the period 2024 to 2029.
Historically, industry’s focus has been on management and stock sustainability, although the potential for growth through higher harvest levels via upward quota adjustment is limited. Indeed, since 2011/12, the total annual harvest has fallen from 4,450t to 1965 t in 2023/2024 (a reduction of 56%). The decreasing productivity of Australian abalone fisheries may be attributed to a number of “complex” causes of which fishing mortality is but one; others include: habitat loss due to Centrostephanus urchin, environmental change & marine heat waves, disease outbreak (AVG, Perkinsus), and reduced natural recruitment, all of which reduce fishery productivity.
Please refer to the below table which clearly shows the decreasing productivity of all abalone fisheries in Australia.
State TACC in tonnes 2011/2012 TACC in tonnes 2017/2018 TACC in tonnes 2022/2023 TACC in tonnes 2023/2024 Tasmania 2366 1333.5 794.5 756 South Australia 834 717.5 564.4 544 Victoria 806 595.3 610.9 457 Western Australia 349 143.4 123.5 108 New South Wales 94 100 100 100 TOTAL 4450 2889.70 2193.3 1965
Notwithstanding the lower harvest levels, the industry remains a significant exporter with a total GVP around $135 million in 2023/24.
Objectives: 1. To coordinate the planning, implementation, and reporting of abalone related R&D projects funded by the FRDC to achieve the outcomes specified in the third ACA Strategic Plan. Specifically, this must be at both the National level and regionally across WA, SA, VIC, NSW and TAS. 2. To facilitate the abalone industry participation in FRDC projects and the extension and utilization of the project results. 3. To deliver resources and processes that consolidates and coordinates Abalone related RD&E planning and funding so that overall RD&E outcomes are delivered in an efficient and cost-effective manner. Read moreRead less