Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100090
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
Surface and Colloid Characterisation Facility. Surface and colloid characterisation facility: Surface science lies at the heart of biointerface and colloid science. This facility will enable particle size, shape, distribution, surface area and charge to be measured as well as the amount of material adsorbed to interfaces, the configuration of that material and the response of the surface to stimuli such as changing pH or salinity. All these parameters influence the properties of these important ....Surface and Colloid Characterisation Facility. Surface and colloid characterisation facility: Surface science lies at the heart of biointerface and colloid science. This facility will enable particle size, shape, distribution, surface area and charge to be measured as well as the amount of material adsorbed to interfaces, the configuration of that material and the response of the surface to stimuli such as changing pH or salinity. All these parameters influence the properties of these important systems. As such this facility will underpin the research of a number of groups across three institutions over the next decade and promote collaboration between scientists with a range of complementary expertise in fields where surface science is important from biology to ionic liquids.Read moreRead less
Tuning adhesion through polymer chain entanglement. Adhesion in materials relies on the ability to tune molecular scale interactions. This project unlocks knowledge to transfer to industry for the intelligent use of polymer additives at a surface. Outcomes will connect fields including ceramic and minerals processing, waste water treatment and for printing and coatings.
Algorithms for multi-scale problems in science and engineering. This project aims to develop theoretical formulations and algorithms for modelling fundamental problems in molecular electrostatics, dispersion force theory, acoustics and electromagnetic scattering in applications where current approaches may be useless. Many engineering applications, from microelectronics to bioengineering devices, need to operate across dimensions from a few millimetres down to a million times smaller. This large ....Algorithms for multi-scale problems in science and engineering. This project aims to develop theoretical formulations and algorithms for modelling fundamental problems in molecular electrostatics, dispersion force theory, acoustics and electromagnetic scattering in applications where current approaches may be useless. Many engineering applications, from microelectronics to bioengineering devices, need to operate across dimensions from a few millimetres down to a million times smaller. This large range of length scales means traditional modelling tools and computational techniques will rapidly become intractable. This project will meet this need to strengthen the Australian technological skill base and contribute to innovations in areas ranging from bioengineering to nanotechnology.Read moreRead less
Modelling of soft multi-scale systems. This project develops realistic physical models and efficient computational methods as the platform technology for giving highly accurate predictions of the complex behaviour of soft deformable systems. The outcomes will add to our understanding of the mechano-biology of living cells and artificial soft body tissues, the cellular uptake of nutrients and drugs, the energy-efficient processing of high value pharmaceutical emulsions and the design of functiona ....Modelling of soft multi-scale systems. This project develops realistic physical models and efficient computational methods as the platform technology for giving highly accurate predictions of the complex behaviour of soft deformable systems. The outcomes will add to our understanding of the mechano-biology of living cells and artificial soft body tissues, the cellular uptake of nutrients and drugs, the energy-efficient processing of high value pharmaceutical emulsions and the design of functional polymers and proteins using molecular models. The new knowledge will advance the frontier of material design and characterisation of soft complex materials.Read moreRead less
Photoreversible hydrogels to study stem cell memory and fate. This project will develop materials whose stiffness can be reversibly increased and decreased by the simple application of light, and use these to build knowledge of how stem cell fate is regulated. The influence of mechanical cues on the structure and organisation of the nucleus will be determined. Expected outcomes are new synthetic and light-reversible culture materials, and fundamental insights into how forces change the nucleus t ....Photoreversible hydrogels to study stem cell memory and fate. This project will develop materials whose stiffness can be reversibly increased and decreased by the simple application of light, and use these to build knowledge of how stem cell fate is regulated. The influence of mechanical cues on the structure and organisation of the nucleus will be determined. Expected outcomes are new synthetic and light-reversible culture materials, and fundamental insights into how forces change the nucleus to alter stem cell aging and fate. The findings will provide critical information required for the future development of assays to measure cell potency and instructive biomaterials to drive stem cell expansion and tissue-regeneration and will have impact by underpinning future advances in stem cell technologies.Read moreRead less
Micro/nano smart surfaces to unlock the potential of multipotent stem cells. This project aims to determine the interplay of micro/nanostructures on stem cell mechanotransduction and to control the cellular environment. It is expected that this will expand our knowledge on how to control stem cell fate. Expected outcomes are novel scalable technologies for micro/nanostructures and smart surfaces, controlled stem-cell expansion and differentiation, and the creation of a library of protein express ....Micro/nano smart surfaces to unlock the potential of multipotent stem cells. This project aims to determine the interplay of micro/nanostructures on stem cell mechanotransduction and to control the cellular environment. It is expected that this will expand our knowledge on how to control stem cell fate. Expected outcomes are novel scalable technologies for micro/nanostructures and smart surfaces, controlled stem-cell expansion and differentiation, and the creation of a library of protein expression based on the cell interactions. These outcomes will provide critical information required for the future development of instructive biomaterials to drive stem cell expansion and tissue-regeneration. Those materials should benefit the future development of efficient and cost-effective regenerative medicine solutions.Read moreRead less
Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to r ....Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to rapidly, at high resolution, elucidate how mechanotransductive cues determine the fate choice of mesenchymal stem cells, and furthermore, how to manipulate them with smart biomaterial design to achieve desired outcomes for tissue engineering. Read moreRead less
An anti-senescence nanoplatform and its underlying mechanism. The project will bring together complementary expertise and skills by combining biomaterials, cell and molecular biology, and engineering, to develop a novel nano-biomaterial platform for anti-senescence and gain an in-depth understanding of its underlying mechanisms. The underlying mechanisms of senescence remain elusive and bone substitutes with anti-senescence property have not been explored and becoming a growing field of interest ....An anti-senescence nanoplatform and its underlying mechanism. The project will bring together complementary expertise and skills by combining biomaterials, cell and molecular biology, and engineering, to develop a novel nano-biomaterial platform for anti-senescence and gain an in-depth understanding of its underlying mechanisms. The underlying mechanisms of senescence remain elusive and bone substitutes with anti-senescence property have not been explored and becoming a growing field of interest in bone regeneration. The project will develop a well-defined and efficient nanomaterial platform with optimal combination of nano-surface features and chemistry for cell rejuvenation, and it will give unprecedented depth of interdisciplinary understanding of senescence rejuvenation mechanisms.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100200
Funder
Australian Research Council
Funding Amount
$270,427.00
Summary
AutoStem: a high performance, automated stem cell bioengineering facility. This project aims to establish an automated stem cell bioengineering ("AutoStem") facility that will enable critical insights into the molecular mechanisms that underly the loss in stem cell function and tissue homeostasis as we age. The AutoStem facility expects to lead to the discovery of the key drivers of stem cell ageing and the development of novel technological solutions to maintain tissue function with age. The o ....AutoStem: a high performance, automated stem cell bioengineering facility. This project aims to establish an automated stem cell bioengineering ("AutoStem") facility that will enable critical insights into the molecular mechanisms that underly the loss in stem cell function and tissue homeostasis as we age. The AutoStem facility expects to lead to the discovery of the key drivers of stem cell ageing and the development of novel technological solutions to maintain tissue function with age. The outcomes produced from the AutoStem facility will have significant economic and social benefits in enabling healthy ageing and increased productivity for an ageing Australia.Read moreRead less
Generating multi-component scaffolding to influence the differentiation of embryonic stem cells. Nervous system diseases are debilitating and will develop in over 50 per cent of people at some time in their life. This project will develop strategies so that stem cells can be utilised to encourage brain repair for the treatment of Parkinson's disease. The technology developed will also be of benefit for the treatment of other nervous system disorders.