A Study To Investigate Alternative Regimens For Pneumococcal Vaccination Of Infants In A Developing Country
Funder
National Health and Medical Research Council
Funding Amount
$1,622,210.00
Summary
Streptococcus pneumoniae (Pnc) is the leading vaccine preventable cause of serious infection in infants. The current Pnc conjugate vaccine is very expensive (approximately USD $200-infant) so it is unlikely to be affordable for most developing countries. Moreover, as health care access in developing countries may be episodic and unreliable, many children do not receive either complete or timely vaccine courses. Therefore, it is important to investigate affordable and flexible ways to deliver thi ....Streptococcus pneumoniae (Pnc) is the leading vaccine preventable cause of serious infection in infants. The current Pnc conjugate vaccine is very expensive (approximately USD $200-infant) so it is unlikely to be affordable for most developing countries. Moreover, as health care access in developing countries may be episodic and unreliable, many children do not receive either complete or timely vaccine courses. Therefore, it is important to investigate affordable and flexible ways to deliver this vaccine, which are safe and effective. A recent WHO-GAVI meeting to address impediments to the introduction of these vaccines in developing countries recognized the need to evaluate other regimens of Pnc conjugate vaccine as an important research priority. This study has been deliberately formulated with that need in mind. The site for this research is Fiji. Although health services are good, Pnc disease, particularly pneumonia, remains the commonest cause of childhood morbidity and mortality. Fiji has good vaccine coverage and was the first Pacific country to introduce Hib vaccine. The arrival of the new, expensive Pnc conjugate vaccine presents a dilemma for Fiji and many similar countries. The expense of this vaccine would consume a large portion of the health budget. This study has two components: 1. A Phase 2 immunogenicity study (involving 750 infants) to evaluate regimens using reduced numbers of doses of Pnc conjugate vaccine, and using timing of dosing and combinations with the Pnc polysaccharide (PS) vaccine that may be more suited to the epidemiology of Pnc disease in developing countries. 2. An epidemiological study will measure the burden of invasive Pnc disease and pneumonia in Fiji. This will be part of a global effort to address these issues, and will be used to develop rapid assessment tools for these diseases in developing countries. We will seek cofounding for this component.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH230100011
Funder
Australian Research Council
Funding Amount
$4,955,854.00
Summary
ARC Research Hub for Value-Added Processing of Underutilised Carbon Waste. This Hub aims to advance upcycling technologies and associated regulatory and social engagement for processing underutilised carbon waste within Australia. Its anticipated goal is to deliver value-added products, and improved technology readiness levels for full exploitation of carbon wastes from agriculture, tyres and plastics. It will also train a large talent pool providing interdisciplinary knowledge and entrepreneuri ....ARC Research Hub for Value-Added Processing of Underutilised Carbon Waste. This Hub aims to advance upcycling technologies and associated regulatory and social engagement for processing underutilised carbon waste within Australia. Its anticipated goal is to deliver value-added products, and improved technology readiness levels for full exploitation of carbon wastes from agriculture, tyres and plastics. It will also train a large talent pool providing interdisciplinary knowledge and entrepreneurial skills for post-hub commercialisation. The Hub will benefit rural Australia by transforming local job markets and manufacturing capability. Ultimately, this Hub will make a significant contribution towards achieving Australia’s National Waste Action Plan goal by 2030, and a circular economy for a sustainable future. Read moreRead less
PROCESSING OF REDUCED-BAND-GAP TITANIA FOR SOLAR-HYDROGEN. The present project involves the development of materials and devices for solar-hydrogen using photo-assisted water decomposition. The research focusses on the processing of titanium dioxide (titania) with substantially enhanced photo-sensitivity and, consequently, increased efficiency of the conversion of solar energy into chemical energy (hydrogen) through imposition of the optimal Ti/O ratio. Significance: processing technology of tit ....PROCESSING OF REDUCED-BAND-GAP TITANIA FOR SOLAR-HYDROGEN. The present project involves the development of materials and devices for solar-hydrogen using photo-assisted water decomposition. The research focusses on the processing of titanium dioxide (titania) with substantially enhanced photo-sensitivity and, consequently, increased efficiency of the conversion of solar energy into chemical energy (hydrogen) through imposition of the optimal Ti/O ratio. Significance: processing technology of titania for photo-electrochemical devices for hydrogen generation and water decontamination. Innovation: processing of titania with reduced band-gap to be achieved through optimised oxygen nonstoichiometry. Outcome: processing technology of titania with outstanding photo-sensitivity.Read moreRead less
Nano-engineered catalysts for sustainable fuel production from waste . This project aims to address two major problems simultaneously-reducing the burden of non-recyclable waste currently going to landfill in Australia, and offsetting Australia’s reliance on imported diesel to support industry and transport needs. While approximately 95% of diesel consumed in Australia is imported, vast quantities of carbon-based waste ends up in landfill. Municipal Solid Waste (MSW) is a mixture of plant-based ....Nano-engineered catalysts for sustainable fuel production from waste . This project aims to address two major problems simultaneously-reducing the burden of non-recyclable waste currently going to landfill in Australia, and offsetting Australia’s reliance on imported diesel to support industry and transport needs. While approximately 95% of diesel consumed in Australia is imported, vast quantities of carbon-based waste ends up in landfill. Municipal Solid Waste (MSW) is a mixture of plant-based waste (including food, garden, paper, and wood) and fossil-fuel derived materials (plastics). Using an innovative and environmentally-sustainable catalytic process, the outcomes of this project are aimed alleviating Australia’s dependence on diesel fuel imports and better waste management solutions in Australia.Read moreRead less
Evaluating potential static liquefaction of tailings to prevent failures. This project aims to reduce risk in the mining industry from failing mine tailings by producing a methodology for predicting the susceptibility of these tailings to static liquefaction. The impact of a mine tailing failure is catastrophic to the downstream community. The project brings together a number of industry partners committed to assisting with verification and adoption of characterisation and designed tools develop ....Evaluating potential static liquefaction of tailings to prevent failures. This project aims to reduce risk in the mining industry from failing mine tailings by producing a methodology for predicting the susceptibility of these tailings to static liquefaction. The impact of a mine tailing failure is catastrophic to the downstream community. The project brings together a number of industry partners committed to assisting with verification and adoption of characterisation and designed tools development in this project. This proposal will integrate results from laboratory element, centrifuge and calibration chamber tests with numerical modelling and in-situ tests to produce a methodology for predicting the susceptibility to static liquefaction.Read moreRead less
Functionally Graded Ultra High Perfomance Concete Structure under Flexure. This project aims to develop a novel multilayer functionally graded concrete structure that is a mixture of normal strength concrete and ultra high performance concrete with the mixing ratio varying in a layer-wise manner, offering a highly cost-effective structural design solution with significantly improved safety and durability over conventional concrete structures. The expected outcomes include the innovative design, ....Functionally Graded Ultra High Perfomance Concete Structure under Flexure. This project aims to develop a novel multilayer functionally graded concrete structure that is a mixture of normal strength concrete and ultra high performance concrete with the mixing ratio varying in a layer-wise manner, offering a highly cost-effective structural design solution with significantly improved safety and durability over conventional concrete structures. The expected outcomes include the innovative design, experimental data on the static and dynamic structural behaviour, development of reliable simulation techniques and optimal design procedures for the proposed structure with greatly reduced material costs. The project will have huge benefits to Australian civil engineering industry and national economy.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453320
Funder
Australian Research Council
Funding Amount
$347,886.00
Summary
Advanced Spectroscopy for Nano-characterisation of Materials Chemistry and Properties. This application proposes to establish a cutting-edge spectroscopic facility which includes; electron energy-loss spectroscopy (EELS), energy-dispersive X-ray spectroscopy (EDS), cathodoluminescence (CL), photoluminescence (PL) and micro-Raman spectroscopy. Each of the spectrometers to be installed has significantly higher sensitivity and resolution than any other facility available in Australia and is capable ....Advanced Spectroscopy for Nano-characterisation of Materials Chemistry and Properties. This application proposes to establish a cutting-edge spectroscopic facility which includes; electron energy-loss spectroscopy (EELS), energy-dispersive X-ray spectroscopy (EDS), cathodoluminescence (CL), photoluminescence (PL) and micro-Raman spectroscopy. Each of the spectrometers to be installed has significantly higher sensitivity and resolution than any other facility available in Australia and is capable of full spectrum imaging. This new spectroscopic infrastructure will enable the knowledge-based development of new materials by allowing complete characterisation of structure-composition-property relationships at the nanometre level.Read moreRead less
Damage Tolerance Approach in Designing and Maintaining Truck Trailers. This project aims to develop a damage tolerance approach in designing and maintaining truck trailers. Combined with field test and computational simulation, machine learning will be used to generate loading spectrums. Following the damage tolerance philosophy, a mature approach in aerospace industry, the fatigue crack growth and the fatigue life will be predicted. In addition, structural optimisation will be applied in traile ....Damage Tolerance Approach in Designing and Maintaining Truck Trailers. This project aims to develop a damage tolerance approach in designing and maintaining truck trailers. Combined with field test and computational simulation, machine learning will be used to generate loading spectrums. Following the damage tolerance philosophy, a mature approach in aerospace industry, the fatigue crack growth and the fatigue life will be predicted. In addition, structural optimisation will be applied in trailer design. This project expects to revolutionize the design and maintenance practices in Australian truck trailer industry. It should provide significant benefits, such as prolonging the life cycle of truck trailers, reducing the tare weight and increasing operating profit, to both trailer producers and users.Read moreRead less
Topological Design of Mechanical Meta-Structures. This project aims to establish a new computational design methodology to address current challenges facing creation of ultralight structures with ultra-high-performance characteristics. The latest technologies in structural topology optimization and its correlated numerical simulation and structural analysis methods will be unified towards an integrated design framework. Expected outcomes include an advanced generative design platform for discove ....Topological Design of Mechanical Meta-Structures. This project aims to establish a new computational design methodology to address current challenges facing creation of ultralight structures with ultra-high-performance characteristics. The latest technologies in structural topology optimization and its correlated numerical simulation and structural analysis methods will be unified towards an integrated design framework. Expected outcomes include an advanced generative design platform for discovering novel geometries to underpin new meta-structure architectures, validated by appropriate fabrication techniques considering their geometric complexity. Such capabilities will benefit defence, civil, aerospace, energy and transport industries that pursue competitive advantage through innovation.Read moreRead less