At least 6 young Australians are diagnosed each day with type 1 diabetes. This Program aims to change the way type 1 diabetes is managed by proactively treating its underlying mechanisms. We will develop safer and more effective immune therapies, develop islet transplantation, look for better markers of disease, and identify ways to preserve insulin-producing cells. The Program aims to propel type 1 diabetes research forward to reach the goals of prevention and cure.
The team has been at the forefront of research on type 1 diabetes for over a decade. This form of diabetes is a major chronic disease from childhood, as well as accounting for at least 10% of adult-onset diabetes. It occurs when the body�s immune system attacks and destroys the beta cells in the pancreas that make insulin, the hormone that controls the level of glucose in the blood. The team was one of the first in the world, and is the only one in Australia, to develop screening programs to tes ....The team has been at the forefront of research on type 1 diabetes for over a decade. This form of diabetes is a major chronic disease from childhood, as well as accounting for at least 10% of adult-onset diabetes. It occurs when the body�s immune system attacks and destroys the beta cells in the pancreas that make insulin, the hormone that controls the level of glucose in the blood. The team was one of the first in the world, and is the only one in Australia, to develop screening programs to test and identify people at risk for type 1 diabetes. They showed that the underlying disease could start years before symptoms occurred and discovered genes that determine the rate at which the underlying disease progresses. They have also found evidence that the disease may be triggered by gut viruses called rotaviruses in genetically-susceptible individuals. They showed that type 1 diabetes could be prevented in a mouse model by getting the immune system to make a protective response to insulin, and then went on to apply this in at-risk humans in a controlled trial of intranasal insulin, the first of its kind. They have used genetic techniques not only to pinpoint the mechanisms responsible for killing the beta cells but also to modify the beta cells to make them resistant to attack by these mechanisms. The multidisciplinary approach of the team will be directed to further understanding the genetic and environmental factors underlying type 1 diabetes and the immune mechanisms, particularly involving special white blood cells called T cells, that kill beta cells. A molecular target of the immune attack, the parent of insulin called proinsulin, will be used, paradoxically, as a tool to regulate the immune system and avert the attack. This will be achieved by giving proinsulin via the mucosa of the naso-respiratory tract or via the bone marrow-derived stem cells, initiallyin the mouse model as a test of feasibility for human application. In parallel with these approaches to prevention, specially constructed viruses will be used to transfer several new genes into beta cells to improve their resistance to immune attack, so that they can be transplanted into people with established diabetes without the need for potentially toxic drugs that suppress the immune system overall. The integrated research of the team is helping to provide a sound, rational base for the eventual prevention and cure of type 1 diabetes.Read moreRead less
Characterization Of HOXA-expressing Human Haematopoietic Cells Generated From Embryonic Stem Cells
Funder
National Health and Medical Research Council
Funding Amount
$622,464.00
Summary
Blood stem cell transplants are used for treating a range of human blood disorders such as leukaemias. However, for many patients, suitable donors cannot be found. We are searching for ways in which embryonic stem cells can be turned into blood stem cells in the laboratory to provide a new source of these cells that could then be used to treat patients.
A Genome-wide Association Study In 2000 Glaucoma Cases With Matched Controls Using Equimoloar DNA Pools
Funder
National Health and Medical Research Council
Funding Amount
$610,267.00
Summary
Glaucoma is a common cause of loss of vision worldwide but we are unable to predict which people are at high risk of blindness. We aim to discover the genetic risk factors for glaucoma. We will use cutting edge genetic technology to assess the whole genome in thousands of patients with glaucoma. We hope to identify important new glaucoma genes, which could lead to the development of diagnostic tests and treatments which will provide the most cost-efficient ways to prevent glaucoma blindness.
Understanding The Causes Of Childhood Congenital Anomalies Of The Kidney And Urinary Tract
Funder
National Health and Medical Research Council
Funding Amount
$609,748.00
Summary
Congenital anomalies of the kidney and urinary tract (CAKUT) is a common cause of renal failure in children. The majority of patients with CAKUT do not know the underlying cause of their renal anomalies. In this proposal we will characterise the developmental events that are perturbed in three mouse models of CAKUT and identify the causal gene responsible in each mouse model. We will translate this information to the clinic by screening patients with CAKUT for mutations in these newly identified ....Congenital anomalies of the kidney and urinary tract (CAKUT) is a common cause of renal failure in children. The majority of patients with CAKUT do not know the underlying cause of their renal anomalies. In this proposal we will characterise the developmental events that are perturbed in three mouse models of CAKUT and identify the causal gene responsible in each mouse model. We will translate this information to the clinic by screening patients with CAKUT for mutations in these newly identified genes.Read moreRead less
The Role Of Renal Dendritic Cells In Infection And Immunity Under Immunosuppression
Funder
National Health and Medical Research Council
Funding Amount
$475,143.00
Summary
Kidney transplantation is the best treatment for kidney failure but it is frequently complicated by bacterial and viral infections that can cause rejection and may cause loss of the kidney. This grant will study the role that dendritic cells in the kidney play in causing rejection and preventing infection. With the knowledge gained from these studies, we will be able to discover new ways to prevent rejection and treat infections of the kidney post transplant.
Advanced Nanocomposites for Enhanced Containment of Hyper-Saline Leachate. This research project seeks to apply nanotechnology approaches to develop tailored materials that are green and cost-effective, which minimise groundwater contamination by hyper-saline industrial leachates and process waters. Australian industries will benefit from lower costs associated with storage, processing and reclamation of process waters, as well as from reduced environmental fines levied by the Environmental Prot ....Advanced Nanocomposites for Enhanced Containment of Hyper-Saline Leachate. This research project seeks to apply nanotechnology approaches to develop tailored materials that are green and cost-effective, which minimise groundwater contamination by hyper-saline industrial leachates and process waters. Australian industries will benefit from lower costs associated with storage, processing and reclamation of process waters, as well as from reduced environmental fines levied by the Environmental Protection Agency due to significantly reduced barrier failure and groundwater contaminations. Australian businesses involved in manufacture, design and construction of environmental barrier systems will have access to new materials and improved technology.Read moreRead less
The development of novel geopolymers incorporating calcium and cellulosic material. Geopolymer technology transforms waste aluminosilicate materials into commercially viable products, which possess superior physical and chemical properties compared to ordinary concrete. These high-tech materials have novel acid and fire resistance applications, e.g. in construction and for the coating of optical fibres. Understanding the chemical relationship between geopolymers and other cementitious materials ....The development of novel geopolymers incorporating calcium and cellulosic material. Geopolymer technology transforms waste aluminosilicate materials into commercially viable products, which possess superior physical and chemical properties compared to ordinary concrete. These high-tech materials have novel acid and fire resistance applications, e.g. in construction and for the coating of optical fibres. Understanding the chemical relationship between geopolymers and other cementitious materials is pivotal to further advances in inorganic polymers. This project uses surface reactivity, spectroscopy, electronmicroscopy and electron diffraction to determine the role of calcium and cellulosic additives in the phase composition, microstructure and properties of geopolymers. Therefore, the factors distinguishing geopolymers from alkali-activated cement and ordinary concrete are identified.Read moreRead less
A fundamental study of the simultaneous gold dissolution during the alkaline oxidation of sulfide containing refractory gold ores and concentrates. The gold industry is Australia's second largest export earner and therefore is immensely important to the Australian economy. The proposed project aims to develop an environmentally acceptable process for treating gold containing sulfidic ores and concentrates that are not amenable to conventional cyanidation. This would provide an enormous benefit t ....A fundamental study of the simultaneous gold dissolution during the alkaline oxidation of sulfide containing refractory gold ores and concentrates. The gold industry is Australia's second largest export earner and therefore is immensely important to the Australian economy. The proposed project aims to develop an environmentally acceptable process for treating gold containing sulfidic ores and concentrates that are not amenable to conventional cyanidation. This would provide an enormous benefit to both the Australian gold industry and the Australian environment. A successful outcome in the research project would also lead to export earnings emanating from technology transfer and enhance Australia's reputation for high quality research and academic endeavours.Read moreRead less