Micro/nano smart surfaces to unlock the potential of multipotent stem cells. This project aims to determine the interplay of micro/nanostructures on stem cell mechanotransduction and to control the cellular environment. It is expected that this will expand our knowledge on how to control stem cell fate. Expected outcomes are novel scalable technologies for micro/nanostructures and smart surfaces, controlled stem-cell expansion and differentiation, and the creation of a library of protein express ....Micro/nano smart surfaces to unlock the potential of multipotent stem cells. This project aims to determine the interplay of micro/nanostructures on stem cell mechanotransduction and to control the cellular environment. It is expected that this will expand our knowledge on how to control stem cell fate. Expected outcomes are novel scalable technologies for micro/nanostructures and smart surfaces, controlled stem-cell expansion and differentiation, and the creation of a library of protein expression based on the cell interactions. These outcomes will provide critical information required for the future development of instructive biomaterials to drive stem cell expansion and tissue-regeneration. Those materials should benefit the future development of efficient and cost-effective regenerative medicine solutions.Read moreRead less
Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to r ....Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to rapidly, at high resolution, elucidate how mechanotransductive cues determine the fate choice of mesenchymal stem cells, and furthermore, how to manipulate them with smart biomaterial design to achieve desired outcomes for tissue engineering. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100200
Funder
Australian Research Council
Funding Amount
$270,427.00
Summary
AutoStem: a high performance, automated stem cell bioengineering facility. This project aims to establish an automated stem cell bioengineering ("AutoStem") facility that will enable critical insights into the molecular mechanisms that underly the loss in stem cell function and tissue homeostasis as we age. The AutoStem facility expects to lead to the discovery of the key drivers of stem cell ageing and the development of novel technological solutions to maintain tissue function with age. The o ....AutoStem: a high performance, automated stem cell bioengineering facility. This project aims to establish an automated stem cell bioengineering ("AutoStem") facility that will enable critical insights into the molecular mechanisms that underly the loss in stem cell function and tissue homeostasis as we age. The AutoStem facility expects to lead to the discovery of the key drivers of stem cell ageing and the development of novel technological solutions to maintain tissue function with age. The outcomes produced from the AutoStem facility will have significant economic and social benefits in enabling healthy ageing and increased productivity for an ageing Australia.Read moreRead less
Generating multi-component scaffolding to influence the differentiation of embryonic stem cells. Nervous system diseases are debilitating and will develop in over 50 per cent of people at some time in their life. This project will develop strategies so that stem cells can be utilised to encourage brain repair for the treatment of Parkinson's disease. The technology developed will also be of benefit for the treatment of other nervous system disorders.
Engineering the Microstructure of Electrodes for Advanced Fuel Cells. A polymer solution-based integration technique is proposed to be developed to fabricate polymer electrolyte membrane fuel cells, allowing for effective engineering of the porous networks and interfaces within electrodes and cells. This novel systems materials engineering approach is expected to overcome the drawbacks of the conventional hot pressing method, enabling precise integration of nanostructured electrodes and membrane ....Engineering the Microstructure of Electrodes for Advanced Fuel Cells. A polymer solution-based integration technique is proposed to be developed to fabricate polymer electrolyte membrane fuel cells, allowing for effective engineering of the porous networks and interfaces within electrodes and cells. This novel systems materials engineering approach is expected to overcome the drawbacks of the conventional hot pressing method, enabling precise integration of nanostructured electrodes and membrane into high-performance, flexible fuel cells. The outcomes of this research aim to provide a unique opportunity for Australia to become a world leader in the rapidly-emerging clean energy technology, and critical manufacturing of new energy generation systems for domestic uses and exports, thereby producing important economic benefits.Read moreRead less
A novel air-cooled fuel cell system. This project presents a novel cooling technology for fuel cell systems. This new design will not only save up to 50 per cent of the material cost but also leads to 20 per cent less fuel consumption compared to the existing fuel cells. This can save us billions of dollars per year with profound impact on our nation's carbon-emission-free alternative energy sources.
Nanophotonic tandem designs for high efficiency solar cells. This project will develop high-efficiency tandem solar cells that combine established silicon cell technology with novel low-cost thin-film solar cells. It will incorporate nanostructured layers between the cells that selectively trap different wavelengths of light, maximising light absorption in the top cell. This will make it possible to use a very thin top cell, reducing the requirements on electronic quality of the material. This p ....Nanophotonic tandem designs for high efficiency solar cells. This project will develop high-efficiency tandem solar cells that combine established silicon cell technology with novel low-cost thin-film solar cells. It will incorporate nanostructured layers between the cells that selectively trap different wavelengths of light, maximising light absorption in the top cell. This will make it possible to use a very thin top cell, reducing the requirements on electronic quality of the material. This project will also develop self-assembly techniques to enable the new nanostructures to be fabricated quickly and cheaply but with a high degree of control. Such cells will allow open the door to higher efficiencies, and lower costs, than is achievable with conventional solar cells.Read moreRead less
Defect engineering in molecular beam epitaxy-grown mercury cadmium telluride. This project aims to develop high quality mercury cadmium telluride (HgCdTe) materials with lower defect density and lower background doping levels. This will enable future, high-performance, lower-cost infrared sensors with the unique features of higher yield, larger array size and higher operating temperature. The project will generate new science and technologies on defect engineering in the epitaxial growth of sem ....Defect engineering in molecular beam epitaxy-grown mercury cadmium telluride. This project aims to develop high quality mercury cadmium telluride (HgCdTe) materials with lower defect density and lower background doping levels. This will enable future, high-performance, lower-cost infrared sensors with the unique features of higher yield, larger array size and higher operating temperature. The project will generate new science and technologies on defect engineering in the epitaxial growth of semiconducting HgCdTe on cadmium zinc telluride (CdZnTe) substrates. This will contribute to the development of core Australian industry sectors such as defence, environmental monitoring, medical imaging, earth remote sensing, mining, and oil and gas.Read moreRead less
Cadmium telluride/Germanium (CdTe/Ge) tandem-junction solar cells for efficiency enhancement in thin-film photovoltaics. The purpose of this project is to improve the efficiency of large-area, thin-film CdTe solar cells by using them in a tandem arrangement with thin-film Ge cells. An increase of 25 per cent in efficiency appears possible, which would greatly improve the prospects for cost-competitive photovoltaic power generation.
Bandgap engineered mercury cadmium telluride heterostructures on gallium antimonide alternative substrates. This project aims to develop bandgap engineered mercury cadmium telluride heterostructures on gallium antimonide alternative substrates to enable high performance lower-cost infrared sensors with high yield, large array size, multiband detection and higher operating temperature. High performance infrared sensors and systems are core enabling technologies in civilian and defence application ....Bandgap engineered mercury cadmium telluride heterostructures on gallium antimonide alternative substrates. This project aims to develop bandgap engineered mercury cadmium telluride heterostructures on gallium antimonide alternative substrates to enable high performance lower-cost infrared sensors with high yield, large array size, multiband detection and higher operating temperature. High performance infrared sensors and systems are core enabling technologies in civilian and defence applications such as remote sensing, environmental monitoring, night vision and national security. This project expects to research into defect generation mechanisms in epitaxial growth of semiconducting mercury cadmium telluride on lattice mismatched substrates. This is expected to contribute to Australian industry sectors, thereby benefiting the Australian economy, society, environment, and national security.Read moreRead less