Role Of Transition Metal Ions And Redox Activity In The Development Of Atherosclerotic Plaques
Funder
National Health and Medical Research Council
Funding Amount
$196,018.00
Summary
Metal ions such as iron and copper have been reproted to be present in the lesions present in diseased human arteries and it has been suggested that these metal ions contribute to the development of atherosclerosis (hardening of the arteries) via their ability to catalyse the formation of highly reactive molecualr fragments called free radicals. Though metal ions are known to catalyse such reactions in test-tube experiments, both the presence of metal ions in diseased arteries and their ability ....Metal ions such as iron and copper have been reproted to be present in the lesions present in diseased human arteries and it has been suggested that these metal ions contribute to the development of atherosclerosis (hardening of the arteries) via their ability to catalyse the formation of highly reactive molecualr fragments called free radicals. Though metal ions are known to catalyse such reactions in test-tube experiments, both the presence of metal ions in diseased arteries and their ability to generate free radicals is controversial. This study will employ a novel, minimally-invasive, technique to assess the nature and quantity of metal ions present in well-defined human and animal lesions at different stages of lesion development. The ability of these metal ions to catalyse free radical formation from components present in the artery wall will also be assessed. The release of these metal ions from the artery wall to added organic molecules will be assessed as this might minimise their potential to cause damage, and provide a possible therapeutic strategy. These studies will therefore provide valuable information as to the significance and role of reactive metal ions in the development of human artery disease and the possible prevention, or minimisation, of such processes.Read moreRead less
Mitochondrial Iron Overload And Friedreich's Ataxia: The Role Of Frataxin In Iron And Haem Metabolism
Funder
National Health and Medical Research Council
Funding Amount
$606,000.00
Summary
Friedreich's ataxia (FA) is due to the lack of a protein known as frataxin. A variety of studies using Baker's yeast and conditional frataxin knockout (KO) mice have shown that deletion of frataxin leads to the accumulation of toxic iron in their mitochondrion. More recently, a variety of studies have shown that FA patients have iron-loading within their mitochondrion. Iron in the highly redox active environment of the mitochondrion could contribute to the generation of cytotoxic radicals that c ....Friedreich's ataxia (FA) is due to the lack of a protein known as frataxin. A variety of studies using Baker's yeast and conditional frataxin knockout (KO) mice have shown that deletion of frataxin leads to the accumulation of toxic iron in their mitochondrion. More recently, a variety of studies have shown that FA patients have iron-loading within their mitochondrion. Iron in the highly redox active environment of the mitochondrion could contribute to the generation of cytotoxic radicals that cause severe damage. Further, cells deficient in frataxin are sensitive to oxidant stress and Fe chelators rescue oxidant-mediated death of cells from FA patients. Indeed, free radical scavengers have shown to be of use in the treatment of this disease. Studies in DR's lab during this NHMRC grant have shown that frataxin is down-regulated by erythroid differentiation or the haem precursor, protoporphyrin IX (BLOOD 2002;99:3813-22). These data indicate a role for frataxin in Fe metabolism and the pathogenesis of FA. In this study we will continue to examine the role of frataxin in the way cells handle Fe using experimental models developed under the current NHMRC grant. These include transfected cell lines with low frataxin expression generated using an expression vector containing anti-sense frataxin cDNA. Further we obtained the frataxin conditional KO mouse and generated a breeding colony. These animals display many of the pathological features of FA and are the best current model of the disease. Indeed, they will be critical for assessing the role of frataxin in Fe metabolism and as a model to test the ability of Fe-binding drugs to prevent the pathology observed. We designed lipid-soluble chelators that can enter the mitochondrion to bind Fe (Biochim Biophys Acta 2001;1536:133-140) and these ligands will be tested to prevent disease progression in the KO mice. This exciting research is crucial for understanding the pathogenesis of FA and in creating new therapies.Read moreRead less
Review the preconditions and the underpinning industry and government structures necessary for the successful implementation of co management Objectives: 1. To investigate the resilience of the various co-management approaches to a changing fishing operational environment (biophysical and socio-governance) 2. To look at the lessons learnt, and the challenges arising from, the implementation of co-management in all jurisdictions; with a view to identifying positive and negati ....Review the preconditions and the underpinning industry and government structures necessary for the successful implementation of co management Objectives: 1. To investigate the resilience of the various co-management approaches to a changing fishing operational environment (biophysical and socio-governance) 2. To look at the lessons learnt, and the challenges arising from, the implementation of co-management in all jurisdictions; with a view to identifying positive and negative drivers 3. To assess the skill sets needed to successfully implement co-management 4. To assess how to resource co-management once the fishery has moved past the RD&E phase 5. To identify the relevant RD&E questions to inform future investment 6. To document recommendations for the future implementation of co management Read moreRead less
Managing human resources in an advanced economy from the perspective of emerging Chinese multinationals: the case of NWII in Australia. This project will investigate human resource management practices in the resources sector in Australia and China. The outcomes of this study will provide important theoretical and operational insights into Chinese foreign direct investment for stakeholders such as the Australian government, community, employees and their representatives.
Aquatic Animal Health Subprogram: Technical Guidelines For The Translocation Of Live Aquatic Animals
Funder
Fisheries Research and Development Corporation
Funding Amount
$18,000.00
Summary
There is an existing National Policy for the Translocation of Live Aquatic Organisms. published by the Ministerial Council of Forestry, Fisheries and Aquaculture (1999). This provides the policy basis for translocation within Australia. Industry concern about the practical processes for achieving translocation approval lead to the funding of FRDC 2002/080. In addition, recent concern among jurisdictions over VER outbreaks has emphasised the need to develop technical guidelines to underpin test ....There is an existing National Policy for the Translocation of Live Aquatic Organisms. published by the Ministerial Council of Forestry, Fisheries and Aquaculture (1999). This provides the policy basis for translocation within Australia. Industry concern about the practical processes for achieving translocation approval lead to the funding of FRDC 2002/080. In addition, recent concern among jurisdictions over VER outbreaks has emphasised the need to develop technical guidelines to underpin testing, as well as policy guidelines, for finfish. Objectives: 1. To progress a common approach to the translocation of live finfish across Australia for aquaculture and restocking purposes. Read moreRead less
Managing the Volunteer Workforce: Flexible Structures and Strategies to Integrate Volunteers and Paid Workers. Volunteers now play a vital role in many service-oriented organisations. This project proposes an innovative framework to assist organisations to develop flexible and appropriate structures and strategies for the management of volunteer and paid workforces. The approach draws upon Atkinson's (1984) "Flexible Firm" concept. A flexibility model is applied to the relationship between volun ....Managing the Volunteer Workforce: Flexible Structures and Strategies to Integrate Volunteers and Paid Workers. Volunteers now play a vital role in many service-oriented organisations. This project proposes an innovative framework to assist organisations to develop flexible and appropriate structures and strategies for the management of volunteer and paid workforces. The approach draws upon Atkinson's (1984) "Flexible Firm" concept. A flexibility model is applied to the relationship between volunteers and the broader workforce. The project aims (a) to understand, conceptualise and evaluate the roles, functions and structure of volunteer groups within paid workforces; (b) to investigate how positive relationships, training, effective communication and flexibility can enhance the contribution of volunteers in the workforce and (c) to propose mechanisms which can improve the deployment of human capital within larger service-oriented organisations such as the National Museum of Australia and Museum of Victoria.Read moreRead less
Given increasing complexity in fisheries management and additional scrutiny on managers, there is a need for fisheries managers from the different jurisdictions to meet as a group to exchange ideas and initiatives and build networks. The Australian Fisheries Management Forum (AFMF), comprised of the respective heads of Commonwealth and State/Territory management agencies, supports the need for such a forum.
Similar cross-fertilisation forums exist between researchers through the Austral ....Given increasing complexity in fisheries management and additional scrutiny on managers, there is a need for fisheries managers from the different jurisdictions to meet as a group to exchange ideas and initiatives and build networks. The Australian Fisheries Management Forum (AFMF), comprised of the respective heads of Commonwealth and State/Territory management agencies, supports the need for such a forum.
Similar cross-fertilisation forums exist between researchers through the Australian Society for Fish Biology (ASFB) and the National Compliance Committee for compliance officers.
It has been a considerable period since fisheries managers workshops were last held. Previous workshops occurred in the 1980s and early 1990s. In March 2014, a two-day national fisheries management workshop was held in Adelaide at the South Australian Aquatic Sciences Centre. This workshop was overseen by the AFMF’s Fisheries Management Sub-Committee (FMSC), with funding support from the Fisheries Research and Development Corporation (FRDC). Recommendations arising from this workshop included convening a subsequent fisheries managers workshop in 12-24 months and the formation of an Australian Professional Fisheries Management Society.
As an interim arrangement pending the potential formation of a professional fisheries managers society as a chapter of ASFB, the FMSC has agreed to hold another fisheries managers workshop, which Queensland will host in October 2017.
Future workshops will be held to coincide with ASFB annually (starting in 2018). Objectives: 1. Hold workshop to solidify the fisheries management working group as part of AFMF Read moreRead less
Tactical Research Fund: Topping Up The "Crystal Bowl" For Barramundi
Funder
Fisheries Research and Development Corporation
Funding Amount
$62,000.00
Summary
Application 2010/018: A "Crystal Bowl" for Barramundi was submitted to the FRDC 2010 round. While the application was rejected the Board indicated it was sympathetic to the approach described and suggested further discussion with Recfishing Research in the development of any future application. It is proposed that a further application be developed for the FRDC 2011 round addressing the issues raised by the Board.
The "Crystal Bowl" concept will underpin any move to regional management ....Application 2010/018: A "Crystal Bowl" for Barramundi was submitted to the FRDC 2010 round. While the application was rejected the Board indicated it was sympathetic to the approach described and suggested further discussion with Recfishing Research in the development of any future application. It is proposed that a further application be developed for the FRDC 2011 round addressing the issues raised by the Board.
The "Crystal Bowl" concept will underpin any move to regional management which is dependent on fine scale data collection on Barramundi in the Fitzroy River system and remains pivotal to the further development of the concept.
Data collected will also be used as baseline data for two coal port developments proposed by Xstrata for the Fitzroy River. These proposals are in their early stages. One proposal at Balaclava Island at the mouth of the river could impact on Barramundi and Threadfin spawning grounds and the other to barge coal down the Fitzroy River will significantly disrupt fishing activities. Discussions are underway with consultants for Xstrata to establish a monitoring program however this is unlikely to commence until the project are approved.
The data required is commercial catch, recreational catch and recruitment. Also required are the environmental conditions including connectivity of wetland lagoons, river flows and rainfall.
Data on commercial catch is available from Fisheries Queensland. CapReef, a community based monitoring program, has collected data on recreational catch since 2007 and recruitment since 1999. A further application for the "Crystal Bowl" will not be submitted until November 2010 and if approved would not commence until around June 2011. Objectives: 1. Collection of commercial catch and recreational catch data for the Fitzroy River in 2010-11 2. Collection of Barramundi recruitment and environmental data for the 2011 recruitment season from January to April 3. Use of that data in the development of commitment to local or regional management among local stakeholders and as baseline data for estimating the impact of proposed coal port developments for the Fitzroy River Read moreRead less
The WRL industry needs to adopt new digital technology to benefit from the digital economy and ensure industry is efficient, highly productive and world-leading in all its management practices and policies. This is fundamental to achieving the WRL Strategic Plan objectives and aims to develop the western rock lobster industry’s competitiveness in digital technologies and ensure that the industry can draw the full benefits from digital innovation.
Discussions on 2017/18 research prioriti ....The WRL industry needs to adopt new digital technology to benefit from the digital economy and ensure industry is efficient, highly productive and world-leading in all its management practices and policies. This is fundamental to achieving the WRL Strategic Plan objectives and aims to develop the western rock lobster industry’s competitiveness in digital technologies and ensure that the industry can draw the full benefits from digital innovation.
Discussions on 2017/18 research priorities and potential areas for collaboration were discussed extensively at the FRDC Annual Stakeholder Workshop in August 2017 with digital technology a commonality across all groups, including scoping data collecting and analysis innovations for policy, management and operations; New apps for commercial recreational catch, management, markets and effort; and Monitoring and sensor (environment to consumers).
There is a need for the WRL to seek expertise to create a new digital platform that will be capable of adding new modules and applications in to the future as required as well as interoperability with other systems. Industry wants to generate and manage its own data (noting that it will make every effort to be compatible with a national industry data management project) and supply the requested data to government when it is required and in the appropriate form. This will require trust but industry needs to accept this responsibility if it wants to act fast and make the most of opportunities in the digital economy. Industry can't rely on government to achieve this.
The WRL needs to identify and implement new digital applications that will improve process efficiency and assist fishers, managers, scientists, regulators and key stakeholders to make more informed and better decisions.
The WRL needs to scope what other fisheries and non-fishing industries are doing nationally and internationally with collecting data and using it in new and innovative ways to improve operations, management, policy, science and decision making.
This program needs to make provision for extension areas such as a new on-line OH&S standards and automatic reporting, digitised traceability from catch to plate, new auto entry catch application, and new monitoring and sensor technologies. Objectives: 1. Scope national and international data collection and analysis innovation to assist policy development and fisheries management 2. Develop and extend a fully digitised database to achieve at least three management objectives 3. Expand database to meet non-managment objectives. Read moreRead less
Experimental Culture Of Trout In Cages In Australian Freshwaters
Funder
Fisheries Research and Development Corporation
Summary
Objectives: 1. Evaluate the potential for cage-cultured trout under Australian conditions, both in regard to environmental criteria and the degree of suitability of locally made materials