Advanced Imaging For Patient Profiling In Patients With Stroke
Funder
National Health and Medical Research Council
Funding Amount
$319,831.00
Summary
Stroke is the leading cause of adult disability in the developed world. Many patients are require rehabilitation which can vary in terms of its success, and in many cases patients can be left with permanent and significant disability. Approaches to understand the neuroplastic changes associated with poststroke motor impairment are limited. This study aims to further our understanding of stroke recovery by undertaking a longitudinal MRI assessment of patients recovering from stroke.
Arterial Spin Labeling Perfusion MR Imaging Of Tissue Pathophysiology In Stroke
Funder
National Health and Medical Research Council
Funding Amount
$402,604.00
Summary
It was estimated that in 2012 there were 420,000 Australians living with disability caused by stroke. This project intends to develop a practical treatment selection approach using advanced imaging to target likely treatment responders which could result in more patients living disability free from improved diagnosis and individualised tailoring of acute interventions using MR imaging. The ultimate aim of this project is the translation and implementation of practical advanced imaging stroke.
I am a clinician researcher in paediatric emergency medicine. My research focus is acute neurological problems and includes both high volume and rare but life threatening conditions in children. Award of an NHMRC Practitioner Fellowship will allow me to address major evidence gaps in the acute care of children presenting to the emergency department with head injuries and brain attacks (acute neurological dysfunction), and to translate the findings into widespread practice.
Evaluation Of Pathogenic Mechanisms Involved In Nuclear And Mitochondrial DNA-encoded Mitochondrial Disorders
Funder
National Health and Medical Research Council
Funding Amount
$196,527.00
Summary
Mitochondria produce energy for the cell. Disorders of mitochondrial function can cause human disease. These diseases are referred to as the mitochondrial disorders. Mitochondrial disorders usually involve multiple tissues, particularly the muscle and brain.These disorders are usually caused by mutations in two different types of DNA; nuclear and mitochondrial DNA. There are many forms of mitochondrial disorders; some affect young children or infants and others cause adult disease. In some cases ....Mitochondria produce energy for the cell. Disorders of mitochondrial function can cause human disease. These diseases are referred to as the mitochondrial disorders. Mitochondrial disorders usually involve multiple tissues, particularly the muscle and brain.These disorders are usually caused by mutations in two different types of DNA; nuclear and mitochondrial DNA. There are many forms of mitochondrial disorders; some affect young children or infants and others cause adult disease. In some cases, genetic defects may cause the same disease and other mutations may cause a wide range of symptoms. The reason why this occurs is unknown. This study investigates several factors that may determine why some mutations lead to a certain disease and why others may cause different diseases. These factors include the variation in energy levels that are produced by the mutant cells, and the different levels of vunerability that mutated cells may have to induced cell death. The goal of this proposal is to identify the factors that lead to mutations causing different clinical symptoms with the overall aim being to design treatment for these chronic diseases.Read moreRead less
Stroke outcomes directly relate to brain tissue rescue. We have contributed to changes in clinical practice through many clinical trials of new protocols and therapeutic strategies. Our program will focus on brain salvage in the pre-hospital setting and the acute hospital environment. We will use novel approaches to enhance brain recovery and design new implementation strategies to maximise the benefits of these therapeutic advances.
I am a practising hospital neurologist and world leader in the prevention and treatment of stroke. Our research aims to realise exciting new break-throughs for stroke sufferers by testing the effectiveness and safety of new treatments that promise to improve recovery of function of damaged brain and reduce disability after stroke, and to prevent recurrent strokes.
Translating Science Into Treatment For Ischemic Stroke
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
My team has pioneered research in Australia that has advanced knowledge in the delivery of safer and more effective stroke therapies. I have developed software for the automated processing of multimodal CT imaging to better select patients for stroke therapies. In order to move this cutting-edge imaging technology into routine clinical practice several processes will occur: Implementation, validation and demonstration of patient benefits, and cost effectiveness of CT imaging selection in routine