Immunological mechanisms underlying the protective immune responses induced by botulinum oil adjuvanted vaccine. Botulism is recognised as an important bacterial pathogen in commercial beef cattle in Australia and around the world. Development of affective, well-researched vaccine against Clostridium botulinum is a high priority for the cattle industry. A novel oil adjuvanted vaccine (Singvac from Fort Dodge Pty Ltd) has advantage over conventional vaccines as it provides full protection follo ....Immunological mechanisms underlying the protective immune responses induced by botulinum oil adjuvanted vaccine. Botulism is recognised as an important bacterial pathogen in commercial beef cattle in Australia and around the world. Development of affective, well-researched vaccine against Clostridium botulinum is a high priority for the cattle industry. A novel oil adjuvanted vaccine (Singvac from Fort Dodge Pty Ltd) has advantage over conventional vaccines as it provides full protection following a single administration. The aims of this study are to investigate the immunological mechanisms underlying the protective response by this novel vaccine using bovine and murine models. This study will discover new control measures for botulism in Australia.Read moreRead less
Mitigating ecosystem impacts by improving the way we breed and manage devils. The Tasmanian ecosystem faces irreversible change due to the decline of the apex predator. An insurance population of Tasmanian devils has been established to prevent extinction of the species. Using the latest sequencing technologies the project aims to determine whether the Tasmanian ecosystem can be restored with Tasmanian devils that are more resilient to a changing environment by improving the way that devils are ....Mitigating ecosystem impacts by improving the way we breed and manage devils. The Tasmanian ecosystem faces irreversible change due to the decline of the apex predator. An insurance population of Tasmanian devils has been established to prevent extinction of the species. Using the latest sequencing technologies the project aims to determine whether the Tasmanian ecosystem can be restored with Tasmanian devils that are more resilient to a changing environment by improving the way that devils are bred and managed in captivity.Read moreRead less
Deformational controls on the dynamics of fluid flow, hydrothermal alteration and gold mineralisation, Argo Gold deposit, WA. Detailed structural analysis, combined with major and trace element geochemistry and stable isotope geochemistry, will be used to explore the 3D evolution of fluid pathways and their relationship to growth of shear zones, vein networks and alteration patterns in the Argo shear-hosted gold deposit. The research will be used to (1) maximise the efficiency of resource defini ....Deformational controls on the dynamics of fluid flow, hydrothermal alteration and gold mineralisation, Argo Gold deposit, WA. Detailed structural analysis, combined with major and trace element geochemistry and stable isotope geochemistry, will be used to explore the 3D evolution of fluid pathways and their relationship to growth of shear zones, vein networks and alteration patterns in the Argo shear-hosted gold deposit. The research will be used to (1) maximise the efficiency of resource definition and extraction, (2) refine resource exploration models, (3) explore the dynamics of gold mineralisation processes in shear zones, and (4) advance understanding of how coupling between deformation, fluid flow, and fluid-rock reaction influence the mechanical behaviour of the Earth's crust.Read moreRead less
Exploration potential and implications for stress transfer modelling in fault-related mineral deposits. Following our success in the application of stress transfer modelling (STM) techniques to understand the clustered distribution of upper crustal, Archean gold deposits within crustal scale fault systems, this project seeks to test and develop the application of STM in (1) gold systems formed below the crustal seismogenic regime, (2) for deposit-scale targeting, and (3) in a range of fault-re ....Exploration potential and implications for stress transfer modelling in fault-related mineral deposits. Following our success in the application of stress transfer modelling (STM) techniques to understand the clustered distribution of upper crustal, Archean gold deposits within crustal scale fault systems, this project seeks to test and develop the application of STM in (1) gold systems formed below the crustal seismogenic regime, (2) for deposit-scale targeting, and (3) in a range of fault-related mineral deposits other than Archaean gold systems. The project will also develop methods to evaluate the combined roles of co-seismic stress transfer and post-seismic fluid redistribution in influencing deposit distribution. The approach provides a new conceptual framework in which to develop exploration strategies for deep earth resources.Read moreRead less
Development and Application of Stress Transfer Modelling for Area Selection in Mesothermal Gold Systems. Many mesothermal gold systems are hosted by low displacement faults and shear zones which develop adjacent to high displacement, crustal-scale faults and shear zones. By analogy with modern, seismogenic fault systems, the gold-hosting structures are interpreted as aftershock arrays whose formation is related to stress redistribution and fluid flow after major slip events on high displacement ....Development and Application of Stress Transfer Modelling for Area Selection in Mesothermal Gold Systems. Many mesothermal gold systems are hosted by low displacement faults and shear zones which develop adjacent to high displacement, crustal-scale faults and shear zones. By analogy with modern, seismogenic fault systems, the gold-hosting structures are interpreted as aftershock arrays whose formation is related to stress redistribution and fluid flow after major slip events on high displacement faults. This project will test and develop Coulomb stress transfer modelling techniques, currently used for aftershock risk assessment, for predicting the distribution of low displacment, gold-hosting structures around crustal-scale shear systems. The technique is expected to provide a powerful tool to assist area selection in fault-related epigenetic ore systems.Read moreRead less
Where to find giant porphyry and epithermal gold and copper deposits. This project will determine when and where giant gold or copper deposits should form, consolidating links with Indonesia, and using South East Asia as a vast natural laboratory in which to examine the effect of large-scale tectonic processes. The project will produce a four-dimensional virtual exploration toolkit to show how to apply the methods.
Evaluating viscum album in tumour eradication strategies. Extracts from the plant parasite mistletoe are, internationally, the most widely used complementary cancer treatments. Providing clear evidence-based research, this project will focus on enhancing mistletoe anti-cancer treatment through the development of novel liposome-based tumour therapies.
Multi-functional nano-modified cementitious materials for well cementing. By incorporating different nano-materials in well cements, this project aims to develop multi-functional cementitious materials with self-sensing properties and greater strength and durability under extreme conditions including high/low temperatures, high pressure and corrosive environments. The integrity and longevity of well cement are paramount for the safe, efficient, environmentally sustainable production of oil and n ....Multi-functional nano-modified cementitious materials for well cementing. By incorporating different nano-materials in well cements, this project aims to develop multi-functional cementitious materials with self-sensing properties and greater strength and durability under extreme conditions including high/low temperatures, high pressure and corrosive environments. The integrity and longevity of well cement are paramount for the safe, efficient, environmentally sustainable production of oil and natural gas resources. Cementing problems are the main factor contributing to incidents during drilling and completion of wells, necessitating costly remediation. It is expected that the novel cement developed in the project will produce safer wells with fewer (gas) environmental emission risks.Read moreRead less
Multiscale dynamics of ore body formation. Future discoveries of giant ore-bodies will undoubtedly be under surface cover. Modelling of new data from South Australia and Western Australia will define targeting criteria for new major ore-bodies, thus exploiting Australia's deep earth resource potential. New understanding of controls on mineralisation decrease exploration risk. Ore-bodies, such as Olympic Dam, have made major contributions to Australia's economy over past decades and promise to ad ....Multiscale dynamics of ore body formation. Future discoveries of giant ore-bodies will undoubtedly be under surface cover. Modelling of new data from South Australia and Western Australia will define targeting criteria for new major ore-bodies, thus exploiting Australia's deep earth resource potential. New understanding of controls on mineralisation decrease exploration risk. Ore-bodies, such as Olympic Dam, have made major contributions to Australia's economy over past decades and promise to add increased value over future decades. This project enhances the probability that at least one other ore-body of this type will be discovered. Such discoveries contribute directly to the wealth of Australia through export earnings and accelerate the development of regional infrastructure and new technological development.Read moreRead less
Reinforced crumbed rubber concrete for residential construction. Reinforced crumbed rubber concrete for residential construction. This project aims to use crumb rubber from used tyres to replace natural sand aggregate in concrete used in housing construction. Globally, very few of the millions of tyres discarded annually are recycled, while natural sand used in concrete is being depleted. This project intends to provide the tyre industry with a viable market for end of life tyres, and the premix ....Reinforced crumbed rubber concrete for residential construction. Reinforced crumbed rubber concrete for residential construction. This project aims to use crumb rubber from used tyres to replace natural sand aggregate in concrete used in housing construction. Globally, very few of the millions of tyres discarded annually are recycled, while natural sand used in concrete is being depleted. This project intends to provide the tyre industry with a viable market for end of life tyres, and the premix concrete industry with a “green” product for the residential construction market. Expected benefits include the increased use of a waste resource (used tyres), reduced use of a scarce natural resource (sand), and the development of an economic but green alternative concrete option for residential builders and owners.Read moreRead less