Organisation, expression and diversity of the sub-telomeric regions of the ancient eukaryote, Giardia duodenalis. We propose to extend our findings on the extreme plasticity of the structure and organisation of the sub-telomeric region of the complete genome of Giardia by more extensive chromosome walking, and comparison of different isolates. These regions are subject to gene conversion, transcriptional silencing, gene mobility, recombination, variable surface protein expression, subtelomeric i ....Organisation, expression and diversity of the sub-telomeric regions of the ancient eukaryote, Giardia duodenalis. We propose to extend our findings on the extreme plasticity of the structure and organisation of the sub-telomeric region of the complete genome of Giardia by more extensive chromosome walking, and comparison of different isolates. These regions are subject to gene conversion, transcriptional silencing, gene mobility, recombination, variable surface protein expression, subtelomeric instability and the insertion of transposable elements, a dynamic balance between structural conservation and rapid evolution. This is a rare opportunity to understand the forces at work in moulding eukaryotic sub-telomeric sequences because Giardia is not constrained by sexual homogenisation and the dynamic variability is retained.Read moreRead less
Biomimetic Insights from Enamel: A Nano-mechanical and Nano-structural Investigation of a Natural Ceramic-like Biocomposite. Enamel is a naturally developed example of an optimised material structure that constitutes the hardest tissue in the human body. In addition it is exposed to severe mechanical and environmental challenges and must last the lifetime of the individual and unlike other tissue is unable to heal or repair itself. Understanding the factors controlling the amazing mechanical pr ....Biomimetic Insights from Enamel: A Nano-mechanical and Nano-structural Investigation of a Natural Ceramic-like Biocomposite. Enamel is a naturally developed example of an optimised material structure that constitutes the hardest tissue in the human body. In addition it is exposed to severe mechanical and environmental challenges and must last the lifetime of the individual and unlike other tissue is unable to heal or repair itself. Understanding the factors controlling the amazing mechanical properties of this tissue will be of great benefit for the design of bio-inspired materials and be important for the development of advanced materials for which Australia already has an enviable reputation.Read moreRead less
Kingdom switching microbial pathogens: the bioinformatics of mutation in the genomes of viruses and bacteria affecting crops, livestock and people. Some organisms that cause infectious diseases have moved between plants and vertebrates, either recently or repeatedly over evolutionary time. Switching between plants and vertebrates strongly influences the way these microbes mutate and evolve. We will search the genomic sequence databases for information about how the choice of host influences muta ....Kingdom switching microbial pathogens: the bioinformatics of mutation in the genomes of viruses and bacteria affecting crops, livestock and people. Some organisms that cause infectious diseases have moved between plants and vertebrates, either recently or repeatedly over evolutionary time. Switching between plants and vertebrates strongly influences the way these microbes mutate and evolve. We will search the genomic sequence databases for information about how the choice of host influences mutations in viral and bacterial genomes and model the evolutionary processes involved. This project will advance our understanding of the fine structure of microbial genomes and the importance of selection pressures on genes. It will lead to better disease management strategies for humans, and for domestic crops and livestock.Read moreRead less
Descartes' Ontology of Everyday Life. Australia has a strong international reputation in philosophy and the history of philosophy. This project will contribute to our standing in the international community of scholars and to the teaching of Australian students in the historical origins of contemporary ideas and problems. It will furthermore contribute to the growing recognition of early modern interdisciplinary studies within Australia by drawing on ideas from the history of science, early mode ....Descartes' Ontology of Everyday Life. Australia has a strong international reputation in philosophy and the history of philosophy. This project will contribute to our standing in the international community of scholars and to the teaching of Australian students in the historical origins of contemporary ideas and problems. It will furthermore contribute to the growing recognition of early modern interdisciplinary studies within Australia by drawing on ideas from the history of science, early modern philosophy, medieval philosophy and the history of early modern thought and ideas.Read moreRead less
The rise of empiricism and the attempt to produce a unified understanding of the world, 1680-1750. Empiricism is often regarded as the characterising feature of modern scientific method, and, in those approaches to psychology and the social and economic sciences that seek to model themselves on successful scientific practice in the physical and life sciences, it often acts as a model of good practice. The project examines the original form of empiricism and shows how it was able to directly enga ....The rise of empiricism and the attempt to produce a unified understanding of the world, 1680-1750. Empiricism is often regarded as the characterising feature of modern scientific method, and, in those approaches to psychology and the social and economic sciences that seek to model themselves on successful scientific practice in the physical and life sciences, it often acts as a model of good practice. The project examines the original form of empiricism and shows how it was able to directly engage questions of value in a novel and revealing way, and how its connection with 'hard' sciences was not merely to provide a methodological gloss on these, but went to the core of what scientific explanation consisted in.Read moreRead less
Isaac Newton's Temple of Solomon and his analysis of sacred architecture: An interpretation and discussion of Babson Manuscript 0434. Babson Manuscript is an important Newtonian manuscript that contains significant cross disciplinary ideas. It requires a multi-disciplinary understanding and skills for its detailed evaluation. Interpretation and analysis of this significant Newtonian manuscript will advance Newtonian scholarship and will be a valuable resource for researchers of architectural his ....Isaac Newton's Temple of Solomon and his analysis of sacred architecture: An interpretation and discussion of Babson Manuscript 0434. Babson Manuscript is an important Newtonian manuscript that contains significant cross disciplinary ideas. It requires a multi-disciplinary understanding and skills for its detailed evaluation. Interpretation and analysis of this significant Newtonian manuscript will advance Newtonian scholarship and will be a valuable resource for researchers of architectural history. This project has both academic and public outcomes. Recently there has been an increased interest in what is commonly perceived as 'ancient wisdom.' Solomon's Temple is one of the most revered ancient symbols. This project will make the history and ideas of this symbol more accessible to the publicRead moreRead less
John Locke, botany and natural kinds. This project will enhance the status of research into early modern science and philosophy in Australia. It is a project of major significance in Locke studies and in the history of botany and it will impinge on a number of current philosophical debates to which Australians are already making a major contribution: the nature of biological species; natural kinds; and scientific method. Those who work on early modern thought in Australia will also benefit from ....John Locke, botany and natural kinds. This project will enhance the status of research into early modern science and philosophy in Australia. It is a project of major significance in Locke studies and in the history of botany and it will impinge on a number of current philosophical debates to which Australians are already making a major contribution: the nature of biological species; natural kinds; and scientific method. Those who work on early modern thought in Australia will also benefit from the close relationship that will be established between the University of Sydney and Oxford University. The publications issuing from the project will be of international significance.Read moreRead less
The Logical Theories of Robert Kilwardby. The project is to produce a monograph on the logical theories of Robert Kilwardby (d. 1279) as they are expounded in his commentary on Aristotle's Prior Analytics, analyzing them from the perspective of modern logic. Kilwardby's commentary - which has not been critically edited, translated, or extensively studied - is remarkable for its fidelity to Aristotle's text, and its innovations in logical theory. This forms part of a larger project jointly with D ....The Logical Theories of Robert Kilwardby. The project is to produce a monograph on the logical theories of Robert Kilwardby (d. 1279) as they are expounded in his commentary on Aristotle's Prior Analytics, analyzing them from the perspective of modern logic. Kilwardby's commentary - which has not been critically edited, translated, or extensively studied - is remarkable for its fidelity to Aristotle's text, and its innovations in logical theory. This forms part of a larger project jointly with Dr Henrik Lagerlund (Uppsala University), to do a critical edition, historical introduction, and English translation of Kilwardby's commentary, together with the present logical analysis.Read moreRead less
Mary Astell (1666-1731): An Historical-Intellectual Role Model for Women in Philosophy. Mary Astell was an early modern English philosopher of exceptional eloquence and skill. This project will produce the first overview of her philosophical thought, the first authoritative critical edition of her magnum opus, and the first assessment of her philosophical relevance today. These outputs have the potential to encourage women's participation in philosophy and in intellectual life more generally, ou ....Mary Astell (1666-1731): An Historical-Intellectual Role Model for Women in Philosophy. Mary Astell was an early modern English philosopher of exceptional eloquence and skill. This project will produce the first overview of her philosophical thought, the first authoritative critical edition of her magnum opus, and the first assessment of her philosophical relevance today. These outputs have the potential to encourage women's participation in philosophy and in intellectual life more generally, outcomes that would be of tremendous benefit to Australia's social and economic fabric. The project will also enhance Australia's already outstanding scholarly reputation for early modern studies and the history of women's ideas.Read moreRead less
Mereological Composition and Material Constitution. This project embodies a number of advances in metaphysics, which is a field of research in which Australia enjoys a considerable international reputation. Our work on material constitution will also further Australia's reputation in the philosophy of mind; some of the most celebrated 20th Century contributions in the philosophy of mind have been written by Australian philosophers.