Analysing gender in research and policy on alcohol-related violence. This project aims to provide insights into gendered aspects of research and policy on alcohol-related violence among young people. It will produce knowledge through a comparative approach encompassing key alcohol policy contexts in Australia, Canada and Sweden. Project outcomes will improve the capacity of health and policy practitioners to understand the relationships between gender, alcohol and violence; reconceptualise resp ....Analysing gender in research and policy on alcohol-related violence. This project aims to provide insights into gendered aspects of research and policy on alcohol-related violence among young people. It will produce knowledge through a comparative approach encompassing key alcohol policy contexts in Australia, Canada and Sweden. Project outcomes will improve the capacity of health and policy practitioners to understand the relationships between gender, alcohol and violence; reconceptualise responses to alcohol-related problems; inform the development of future alcohol research and policy; increase the capacity to respond more effectively to alcohol use; and reduce alcohol-related harm.Read moreRead less
Ethical and Social Issues in Translating Epigenetics into Antenatal Care. This project aims to investigate how knowledge about the intergenerational transmission of health and disease is shaping antenatal care in Australia. It expects to generate new knowledge about how the science of epigenetics can be used to address social inequality and is anticipated to have impact across the social sciences, bioethics and public health. Expected outcomes of the project include novel theoretical approaches ....Ethical and Social Issues in Translating Epigenetics into Antenatal Care. This project aims to investigate how knowledge about the intergenerational transmission of health and disease is shaping antenatal care in Australia. It expects to generate new knowledge about how the science of epigenetics can be used to address social inequality and is anticipated to have impact across the social sciences, bioethics and public health. Expected outcomes of the project include novel theoretical approaches to the ethics of pregnancy, along with guidance tools to shape the use of epigenetics in antenatal care and social policy to reduce social inequalities. This should provide significant benefits, improving information and support available to vulnerable women as they negotiate maternal health and social services. Read moreRead less
New models for the role of chromatin in controlling inducible gene expression. This proposal aims to test novel models of how packaging of DNA in the nucleus plays a fundamental role in gene expression. Understanding these concepts is important in the context of successful gene therapy where major hurdles need to be overcome. This work also has implications for somatic cell therapy since it is important to understand how genes are expressed in order to successfully reprogram cells. Both of these ....New models for the role of chromatin in controlling inducible gene expression. This proposal aims to test novel models of how packaging of DNA in the nucleus plays a fundamental role in gene expression. Understanding these concepts is important in the context of successful gene therapy where major hurdles need to be overcome. This work also has implications for somatic cell therapy since it is important to understand how genes are expressed in order to successfully reprogram cells. Both of these areas are important to the Biotechnology industry. Answering questions about higher order chromatin structure in gene transcription will provide cutting edge, innovative knowledge that will have international significance. Read moreRead less
3D Printed Food for People with Swallowing Disability. This project aims to identify ways that 3D food printing (additive manufacturing using real food in a device like a ink-jet printer) could be used to improve the visual appeal of puree meals for people with swallowing difficulty, who make up ~8% of the world's population. This study will be the first to include people with swallowing disability (e.g., related to cerebral palsy, stroke, older age) and their supporters in examining the views a ....3D Printed Food for People with Swallowing Disability. This project aims to identify ways that 3D food printing (additive manufacturing using real food in a device like a ink-jet printer) could be used to improve the visual appeal of puree meals for people with swallowing difficulty, who make up ~8% of the world's population. This study will be the first to include people with swallowing disability (e.g., related to cerebral palsy, stroke, older age) and their supporters in examining the views and experiences of stakeholders on the impact of 3D food printing on quality of life, enjoyment, participation, and safety. Outcomes include new knowledge on factors affecting the implementation of 3D food printing in disability and aged care services, to inform policy, practice, and future research.Read moreRead less
Socio-economic determinants of future fertility trends in Australia and other developed countries. Future demographic trends will do much to determine Australia's future. Fertility levels will dominate in deciding population numbers, age structure, and the optimum balance between natural increase and immigration. Current ARC-supported research on the theory of demographic transition provides a paradigm for forecasting likely trends, especially when employed with an existing data bank of findings ....Socio-economic determinants of future fertility trends in Australia and other developed countries. Future demographic trends will do much to determine Australia's future. Fertility levels will dominate in deciding population numbers, age structure, and the optimum balance between natural increase and immigration. Current ARC-supported research on the theory of demographic transition provides a paradigm for forecasting likely trends, especially when employed with an existing data bank of findings on social and demographic interrelations. The research is of great national benefit because even small differences in age structure will impact significantly on the size of the labour force, health services, the support of the aged and taxation levels. Relevant policy decisions will need to be made in the near future.Read moreRead less
Interactive Demographic Transition: Analysis and Theory. The demographic transition, or decline in mortality and fertility levels to produce the modern small family and normally long-lived individuals, may well be the most important social change of our time. It has occasioned much research but theory is still in disarray. This is at least partly explained by a disregard for feed-back mechanisms in the form of organized movements supporting and opposing such demographic change. My aim is to r ....Interactive Demographic Transition: Analysis and Theory. The demographic transition, or decline in mortality and fertility levels to produce the modern small family and normally long-lived individuals, may well be the most important social change of our time. It has occasioned much research but theory is still in disarray. This is at least partly explained by a disregard for feed-back mechanisms in the form of organized movements supporting and opposing such demographic change. My aim is to reanalyze data from my own and others? work, taking such interactions into account, to produce a demographic transition theory suited both to historical explanation and the guidance of contemporary policy.Read moreRead less
Differential expression and functional analysis of genes controlling metamorphosis and early neurogenesis of a model lower animal, the coral Acropora. This study will analyse, at a molecular level, the response of coral larvae to stimuli inducing settlement from the plankton and the process of establishment of a sessile, calcified colony. The knowledge gained will facilitate induction of settlement on demand in the most effective way. We will characterise known candidate genes which may be invo ....Differential expression and functional analysis of genes controlling metamorphosis and early neurogenesis of a model lower animal, the coral Acropora. This study will analyse, at a molecular level, the response of coral larvae to stimuli inducing settlement from the plankton and the process of establishment of a sessile, calcified colony. The knowledge gained will facilitate induction of settlement on demand in the most effective way. We will characterise known candidate genes which may be involved in settlement, and reveal a more complete picture using subtractive hybridisation. Studies of the nervous system and the changes that it undergoes at metamorphosis will promote understanding of the control of metamorphosis, and insights into how more complex nervous systems may have evolved.Read moreRead less
Changing children’s chances: Exploring pathways to developmental inequities. This project aims to investigate the causes of health and developmental inequities between Australian children. Inequities are increasingly observed in Australian children’s physical health, social and emotional wellbeing, and academic learning. Such inequities are unjust, unnecessary and potentially preventable. This project aims to understand the pathways leading to these inequities by examining the many contexts in w ....Changing children’s chances: Exploring pathways to developmental inequities. This project aims to investigate the causes of health and developmental inequities between Australian children. Inequities are increasingly observed in Australian children’s physical health, social and emotional wellbeing, and academic learning. Such inequities are unjust, unnecessary and potentially preventable. This project aims to understand the pathways leading to these inequities by examining the many contexts in which children and their families live and grow. Through a series of innovative analyses using existing data, the project aims to identify potentially modifiable factors at the child, family, school, and community level that contribute to developmental inequities. Understanding of the most promising leverage points for interventions to reduce inequities for Australian children could be used to inform policy.Read moreRead less
Epigenetic silencing in vertebrates: evolution and function from the bottom-up. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional genomics in Australia, with the research priority of Frontier Technologies for Building and Transforming Australian Industries and priority goals in Breakthrough Science and Frontier Technologies. This project focuses on important biological questions surrounding gene regulation and sex chromosome evolution. Inte ....Epigenetic silencing in vertebrates: evolution and function from the bottom-up. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional genomics in Australia, with the research priority of Frontier Technologies for Building and Transforming Australian Industries and priority goals in Breakthrough Science and Frontier Technologies. This project focuses on important biological questions surrounding gene regulation and sex chromosome evolution. International attention has already resulted in genome characterization of Australian icons (wallaby, Tasmanian devil and platypus), more research on these, and other Australian animals, will further highlight the importance of Australian fauna and impact positively on our scientific profile.Read moreRead less
Origin and evolution of genes on the human X chromosome. Two groups of functionally related genes are found on the human X chromosome in disproportionately high numbers. I will test whether an uneven distribution of genes is common in mammalian genomes, or whether the human X is special. I will test hypotheses of how the gene groups arose on the human X by comparing their location and expression patterns in other mammals, and other vertebrates. It will then be clear whether the ancestral autosom ....Origin and evolution of genes on the human X chromosome. Two groups of functionally related genes are found on the human X chromosome in disproportionately high numbers. I will test whether an uneven distribution of genes is common in mammalian genomes, or whether the human X is special. I will test hypotheses of how the gene groups arose on the human X by comparing their location and expression patterns in other mammals, and other vertebrates. It will then be clear whether the ancestral autosome was ?chosen?, whether it ?selfishly? accumulated these genes, or whether the function of genes changed in response to selective pressures.Read moreRead less