Developing new tools for chemical biology. We will develop new synthetic strategies to support the development of small molecule chemical probes that bind with high affinity and specificity to a target protein. Such chemical probes are invaluable in elucidating the role of specific proteins in biological pathways. Our novel strategy aims to be rapid, efficient in its use of materials and widely applicable to a range of different protein targets. The core of our approach involves using biophysica ....Developing new tools for chemical biology. We will develop new synthetic strategies to support the development of small molecule chemical probes that bind with high affinity and specificity to a target protein. Such chemical probes are invaluable in elucidating the role of specific proteins in biological pathways. Our novel strategy aims to be rapid, efficient in its use of materials and widely applicable to a range of different protein targets. The core of our approach involves using biophysical binding assays to characterise compounds that are produced on small scale using parallel chemistry. This approach will enable better chemical probes to be developed more rapidly at lower cost than is currently possible.Read moreRead less
Glycan-based prebiotic approaches to increase food safety in Australia. Since the launch of the first Australian Animal Sector National Antimicrobial Resistance Plan (2018) several approaches have been suggested to reduce the use antibiotics in agriculture, however no alternatives to antibiotics have been suggested or trialled. In this proposal we aim to develop a novel glycan-based prebiotic strategy to reduce Campylobacter jejuni colonisation in chicken and poultry by disrupting important glyc ....Glycan-based prebiotic approaches to increase food safety in Australia. Since the launch of the first Australian Animal Sector National Antimicrobial Resistance Plan (2018) several approaches have been suggested to reduce the use antibiotics in agriculture, however no alternatives to antibiotics have been suggested or trialled. In this proposal we aim to develop a novel glycan-based prebiotic strategy to reduce Campylobacter jejuni colonisation in chicken and poultry by disrupting important glycan-glycan interactions. Outcomes of this proposal is a cost-effective antibiotic- and vaccine-independent animal feed supplement strategy that will decrease the risk of human food-borne illness and therefore promoting food safety and public health in Australia. Read moreRead less
Addressing Evidence Gaps And Developing A Novel Treatment To Reduce The Burden Of Post-traumatic Knee Osteoarthritis
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Arthritis caused by knee injury has a devastating personal and economic impact. Research is needed to develop strategies to prevent arthritis and improve outcomes for people living with arthritis. This research will improve treatment of knee injury to reduce arthritis risk, understand why some people are more likely to get knee arthritis, and develop a new treatment to improve outcomes for people living with knee arthritis. A clinical trial will determine if this treatment achieves this aim.
Early Career Industry Fellowships - Grant ID: IE230100410
Funder
Australian Research Council
Funding Amount
$452,085.00
Summary
Bridging the gap between rockfall theory and engineering practice. Fragmentation is often observed post rockfall events and it is recognised as a critical aspect of adequate rockfall risk management. Yet, rockfall fragmentation is a complex phenomenon still poorly understood and not properly considered in engineering practice. This project aims at developing a theoretical and stochastic fragmentation framework, based on high-quality and comprehensive experimental data, in collaboration with lead ....Bridging the gap between rockfall theory and engineering practice. Fragmentation is often observed post rockfall events and it is recognised as a critical aspect of adequate rockfall risk management. Yet, rockfall fragmentation is a complex phenomenon still poorly understood and not properly considered in engineering practice. This project aims at developing a theoretical and stochastic fragmentation framework, based on high-quality and comprehensive experimental data, in collaboration with leading international industry partners that provide advanced geotechnical design tools to practitioners around the world. The outcomes of the project will bridge the gap between rockfall theory and engineering practice. It will allow for more cost-effective and safer design of rockfall protection structures.Read moreRead less
A novel granular stress sensor for soil exploration. The project aims to develop a novel way to measure the state of soils and improve the perception of soft ground robots by combining advances in sensor development with granular physics. The project expects to produce new insights in geotechnical engineering by utilising innovative sensors compliant with the surrounding medium, thus improving measurements across broader deformation conditions than existing technologies. Expected outcomes includ ....A novel granular stress sensor for soil exploration. The project aims to develop a novel way to measure the state of soils and improve the perception of soft ground robots by combining advances in sensor development with granular physics. The project expects to produce new insights in geotechnical engineering by utilising innovative sensors compliant with the surrounding medium, thus improving measurements across broader deformation conditions than existing technologies. Expected outcomes include an increased ability to prevent soil failures by utilising these sensors to monitor stress levels underground. This should provide significant benefits for saving critical infrastructure from environmental and geotechnical failures, including landslides, tunnel collapses, and tailings dam damages.Read moreRead less
The Social Life of Death. This project aims to investigate experiences of death, dying and bereavement amidst rapid social, economic and political transformation. In the wake of COVID19, and as Australia’s anticipated ‘death boom’ approaches, how to foster good deaths has never been more uncertain, nor more urgent. Drawing on innovative methods and socio-cultural theory, and working in partnership with families and communities, this project aims to generate new knowledge to better inform and imp ....The Social Life of Death. This project aims to investigate experiences of death, dying and bereavement amidst rapid social, economic and political transformation. In the wake of COVID19, and as Australia’s anticipated ‘death boom’ approaches, how to foster good deaths has never been more uncertain, nor more urgent. Drawing on innovative methods and socio-cultural theory, and working in partnership with families and communities, this project aims to generate new knowledge to better inform and improve policy and spark cultural renewal around the end of life. Expected outcomes include setting the international benchmark for novel scholarly understandings of death, dying and bereavement, and centring community voices in addressing contemporary challenges to dying well.
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A community based social identity approach to loneliness. Loneliness across Australia is a deep concern. Social prescribing is a novel community-based approach to managing loneliness, however it is unclear when and in what circumstances it is effective. This project aims to test a social identity approach to loneliness, incorporating longitudinal, cross-sectional, and experimental methods to understand how best to engage isolated people in group programs. The expected benefits of this project ar ....A community based social identity approach to loneliness. Loneliness across Australia is a deep concern. Social prescribing is a novel community-based approach to managing loneliness, however it is unclear when and in what circumstances it is effective. This project aims to test a social identity approach to loneliness, incorporating longitudinal, cross-sectional, and experimental methods to understand how best to engage isolated people in group programs. The expected benefits of this project are to produce a validated social prescribing model that can be implemented in multiple settings across Australia in order to reduce loneliness, strengthen communities, and guide more appropriate uses of health services.Read moreRead less
Improving Indigenous health and wellbeing over the family life course. Improving Indigenous health and wellbeing over the family life course. This project aims to reduce Indigenous health inequalities, a major social and economic problem, by improving the policy relevant evidence base on the determinants of Indigenous health and wellbeing. This project will compare the impact of the family life course on the health and wellbeing of Indigenous and non-Indigenous mothers and children. It will use ....Improving Indigenous health and wellbeing over the family life course. Improving Indigenous health and wellbeing over the family life course. This project aims to reduce Indigenous health inequalities, a major social and economic problem, by improving the policy relevant evidence base on the determinants of Indigenous health and wellbeing. This project will compare the impact of the family life course on the health and wellbeing of Indigenous and non-Indigenous mothers and children. It will use survey data that follows them over time to: 1) identify family structures that enhance or harm health and wellbeing, and; 2) track changes in health and wellbeing before, during and after family transitions (i.e. births, relationship changes). Anticipated results are better targeted policy interventions to reduce Indigenous health inequalities.Read moreRead less
Enhancing sleep and wellbeing in working families. This project aims to investigate the role of sleep on individuals’ health by measuring Australians' sleep patterns relative to work and family demands. This project expects to generate new knowledge in the sociology of sleep using innovative data collection bringing together cross-national, nationally representative, longitudinal and physiological data on Australians’ sleep patterns. Expected outcomes of this project are to identify the social a ....Enhancing sleep and wellbeing in working families. This project aims to investigate the role of sleep on individuals’ health by measuring Australians' sleep patterns relative to work and family demands. This project expects to generate new knowledge in the sociology of sleep using innovative data collection bringing together cross-national, nationally representative, longitudinal and physiological data on Australians’ sleep patterns. Expected outcomes of this project are to identify the social and biological determinants of sleep and their links with health, family and economic policy recommendations.Read moreRead less
Reducing rocket resonance is the key to safer spaceflight. This fellowship considers a particularly dangerous component of rocket launch, which is the potential for destructive feedback loops to form either in the nozzle, or between the nozzle and the launch pad. CI Edgington-Mitchell is a world leader in the study of resonance in jet engines, having developed best-in-field methodologies for the problem. In this innovative fellowship, he will apply these methodologies to better understand the da ....Reducing rocket resonance is the key to safer spaceflight. This fellowship considers a particularly dangerous component of rocket launch, which is the potential for destructive feedback loops to form either in the nozzle, or between the nozzle and the launch pad. CI Edgington-Mitchell is a world leader in the study of resonance in jet engines, having developed best-in-field methodologies for the problem. In this innovative fellowship, he will apply these methodologies to better understand the dangerous resonances that can occur during rocket launch, using a combination of experimental, numerical, and theoretical techniques, in partnership with NASA, Stanford, and the CNRS.Read moreRead less