Determining the social value of extreme, mixed-use urban developments. Using an Adelaide case study, UCity, this project will investigate the social benefit of building mixed-use vertical communities in the Australian urban context. Using an innovative Social Value Framework, the project will establish and demonstrate the multi-dimensional impacts of such developments in practice. The project utilises citizen science for real time auditing of the built environment by residents and users; smart t ....Determining the social value of extreme, mixed-use urban developments. Using an Adelaide case study, UCity, this project will investigate the social benefit of building mixed-use vertical communities in the Australian urban context. Using an innovative Social Value Framework, the project will establish and demonstrate the multi-dimensional impacts of such developments in practice. The project utilises citizen science for real time auditing of the built environment by residents and users; smart technologies for environmental and behavioural monitoring; and data analytics and design automation for spatial analysis of building use. The results will inform new models of sustainable high-rise, mixed-use buildings; providing evidence for a Social Value Framework to become a core consideration in Australian industry.Read moreRead less
Developing Resilient Housing for Low Socio-Economic Older People. The project aims to advance knowledge about housing design and indoor environment to improve the wellbeing of older people with low socio-economic status in South Australia, including those with culturally and linguistically diverse backgrounds. It will gather information about indoor living environment and relationships with wellbeing of the occupants, household energy use and operational costs, to explore affordable improvement ....Developing Resilient Housing for Low Socio-Economic Older People. The project aims to advance knowledge about housing design and indoor environment to improve the wellbeing of older people with low socio-economic status in South Australia, including those with culturally and linguistically diverse backgrounds. It will gather information about indoor living environment and relationships with wellbeing of the occupants, household energy use and operational costs, to explore affordable improvement strategies. The project is significant to address the problems faced by one-third of the population who are unable to afford proper housing and fuel-poor. Improved living conditions will lead to better quality of life and reduce public health costs while providing environmental benefits through reduced energy use.Read moreRead less
Predicting Drug-drug Interactions Due To Tyrosine Kinase Inhibitors: Inhibition Of Drug Metabolising Enzymes And Transporters
Funder
National Health and Medical Research Council
Funding Amount
$535,495.00
Summary
Tyrosine kinase inhibitors (TKIs) are a new class of anticancer agents. Cancer patients typically receive multiple drugs, for the treatment of cancer and other diseases, increasing the probability of interactions between coadministered drugs. Despite the widespread use of TKIs, their potential to cause drug interactions is poorly understood. Using novel in vitro approaches, this project will identify drug interactions precipitated by TKIs thereby improving drug efficacy and patient safety.
Development of Novel Metaconcrete to Resist Impulsive Loads. This project aims to develop innovative metaconcrete for structural protection by utilising the concept of phononic crystals and metamaterials which has been recently developed by physicists. Traditional construction materials are used in new structural forms to mitigate dynamic loading effects by exploiting the unique characteristics of the proposed metaconcrete. Theoretical, numerical and experimental methods will be used to derive t ....Development of Novel Metaconcrete to Resist Impulsive Loads. This project aims to develop innovative metaconcrete for structural protection by utilising the concept of phononic crystals and metamaterials which has been recently developed by physicists. Traditional construction materials are used in new structural forms to mitigate dynamic loading effects by exploiting the unique characteristics of the proposed metaconcrete. Theoretical, numerical and experimental methods will be used to derive the best performing metaconcrete and verify its static and dynamic load resistant capacities. The expected outcomes of the project will lead to innovative extreme-loading resistant designs and provide significant benefit to the Australian construction industry, general public and economy.Read moreRead less
Retrofitted brick masonry buildings - are they reliable over the long term? The aim of this project is to investigate the long-term reliability of a new earthquake strengthening technique for brick buildings. The technique involves the use of fibre reinforced polymer (FRP) strips as reinforcement for brick walls and has been shown to give substantial instantaneous strength increases. However, no research has been undertaken to ensure that the improved strength is sustained over the remaining lif ....Retrofitted brick masonry buildings - are they reliable over the long term? The aim of this project is to investigate the long-term reliability of a new earthquake strengthening technique for brick buildings. The technique involves the use of fibre reinforced polymer (FRP) strips as reinforcement for brick walls and has been shown to give substantial instantaneous strength increases. However, no research has been undertaken to ensure that the improved strength is sustained over the remaining life of the building. The only related research involves reinforced concrete which suggests that a reduction of at least 33 per cent could be expected. Hence, this project will quantify the long-term strength of FRP reinforced brickwork to enable engineers to safely apply this new cost-effective retrofit technique.Read moreRead less
Composite tubular construction subject to impact and blast loading. This project will advance the knowledge of composite tubular members and connections under impact and blast loading. It will provide confident design methodology against impact and blast loading for buildings designated as prominent targets or items of critical infrastructure, to save lives and reduce losses.
Ontology-based collaboration in design. The design process of a building project establishes function, form and performance for the final building. When multiple participants from varying professions are involved there is a serious problem in coordinating, communicating, and locating information around each design decision. Establishing an ontology for this process, and using this ontology to structure all participant communication, will allow the requisite information from all participants to b ....Ontology-based collaboration in design. The design process of a building project establishes function, form and performance for the final building. When multiple participants from varying professions are involved there is a serious problem in coordinating, communicating, and locating information around each design decision. Establishing an ontology for this process, and using this ontology to structure all participant communication, will allow the requisite information from all participants to be considered for each design decision. This will greatly reduce rework and poor design decisions based on missed information. It will also ensure that participants are aware of all related information for their particular design tasks.Read moreRead less
Optimization of internal pressure for designing industrial buildings. The project seeks to understand the internal pressure in a building during windstorms, to improve safety and performance. The internal pressure in a building is dependent on its volume and flexibility and the sizes of openings in the building envelope, and is a critical loading parameter in building design. Windstorm damage investigations have shown that incorrect internal pressures are frequently used in building design, lead ....Optimization of internal pressure for designing industrial buildings. The project seeks to understand the internal pressure in a building during windstorms, to improve safety and performance. The internal pressure in a building is dependent on its volume and flexibility and the sizes of openings in the building envelope, and is a critical loading parameter in building design. Windstorm damage investigations have shown that incorrect internal pressures are frequently used in building design, leading to damage. This project aims to study the internal pressures generated in buildings with a range of volumes and openings in the envelope. A combination of model-scale and full-scale tests and theoretical analysis are planned to determine critical parameters for highly turbulent air-flow though openings. Results will inform the revision of design data in codes and of guidelines for consistent, optimal design of buildings.Read moreRead less
Bushfires, social connectedness and mental health. The 2009 Victorian bushfires caused much loss of life, property destruction, and community disturbance. It is important for Promoting Better Health and Strengthening the Social and Economic Fabric that an accurate understanding is achieved of the factors that contribute to optimal recovery from natural disasters. This project will survey people affected by the fires over 5 years to both profile adaptation after the fires and to identify the i ....Bushfires, social connectedness and mental health. The 2009 Victorian bushfires caused much loss of life, property destruction, and community disturbance. It is important for Promoting Better Health and Strengthening the Social and Economic Fabric that an accurate understanding is achieved of the factors that contribute to optimal recovery from natural disasters. This project will survey people affected by the fires over 5 years to both profile adaptation after the fires and to identify the individual and community processes that influence outcome. This project being undertaken in partnership by academic, disaster management, health and community organisations will provide crucial information for shaping policy for disaster management in the years ahead.Read moreRead less