Toll Like Receptor signalling as a mediator of sex differences in pain, opioid and alcohol action. Brain immunology will be examined in this project to see if the signalling of a receptor called Toll Like Receptor 4 can explain sex differences in pain, and the action of pain killers and alcohol. These findings will have significant implications on the understanding of male and female brains, and will assist in the design of new drugs to treat brain and spinal cord diseases.
Investigating memory reliability in intoxicated witnesses of crime. Eyewitness testimony is a crucial piece of evidence for solving a crime. Inaccurate testimony leads to miscarriages of justice such as failed prosecutions or false convictions. Many witnesses and victims are affected by alcohol or other drugs during the crime. This project brings together a multidisciplinary team aiming to improve understanding of how intoxication with different substances affects the reliability of victim and w ....Investigating memory reliability in intoxicated witnesses of crime. Eyewitness testimony is a crucial piece of evidence for solving a crime. Inaccurate testimony leads to miscarriages of justice such as failed prosecutions or false convictions. Many witnesses and victims are affected by alcohol or other drugs during the crime. This project brings together a multidisciplinary team aiming to improve understanding of how intoxication with different substances affects the reliability of victim and witness memory accuracy. Crucially, crimes are frequently distressing; therefore the interaction between intoxication and stress urgently requires exploration. This project will significantly advance our understanding of key mechanisms behind drug effects on memory, and support fairer judicial outcomes for all. Read moreRead less
Burnt out and worn out or engaged and energised? Exploring the antecedents and consequences of burnout and engagement in drug-treatment specialists. This project will have significant social benefits in regard to the health and well being of workers in the health and human services sector. The results and outcomes of this project will contribute to the National Research Priority of "Promoting and Maintaining Good Health" by (1) contributing to the design of workplace interventions to facilitate ....Burnt out and worn out or engaged and energised? Exploring the antecedents and consequences of burnout and engagement in drug-treatment specialists. This project will have significant social benefits in regard to the health and well being of workers in the health and human services sector. The results and outcomes of this project will contribute to the National Research Priority of "Promoting and Maintaining Good Health" by (1) contributing to the design of workplace interventions to facilitate health and wellbeing in the workplace, (2) contributing to the policies designed to address problems with worker retention in the AOD workforce, and (3) contributing to the development of strategies and interventions which are likely to benefit a key disadvantage group - individuals with alcohol or other drug problems.Read moreRead less
Work Experience: Labour Law at the Intersection of Work and Education. This project aims to examine the regulatory challenges relating to post-secondary work experience, such as internships, in the areas of labour and employment, anti-discrimination and workers compensation law in Australia. The analysis is designed to establish a global and comparative context, examining policy and regulatory responses in Canada, Europe (including Britain), New Zealand, and the United States of America and at t ....Work Experience: Labour Law at the Intersection of Work and Education. This project aims to examine the regulatory challenges relating to post-secondary work experience, such as internships, in the areas of labour and employment, anti-discrimination and workers compensation law in Australia. The analysis is designed to establish a global and comparative context, examining policy and regulatory responses in Canada, Europe (including Britain), New Zealand, and the United States of America and at the international level. By offering a comprehensive analysis of the theoretical and practical implications of law's boundary between work and education, it is expected to identify optimum approaches to the regulation of post-secondary work experience, and thereby expand policy debates and enhance future law reform.Read moreRead less
Properties of nanomaterials determine their disposal by liver cells. This project aims to understand how the liver handles and is affected by nanomaterials in the body. Nanomaterials are widely used in industrial, environmental, consumer and drug products, but how they affect human health is poorly understood. This project will characterise the spatiotemporal distribution of a set of nanomaterials with defined attributes in naïve and modified livers using chemistry, imaging and biological method ....Properties of nanomaterials determine their disposal by liver cells. This project aims to understand how the liver handles and is affected by nanomaterials in the body. Nanomaterials are widely used in industrial, environmental, consumer and drug products, but how they affect human health is poorly understood. This project will characterise the spatiotemporal distribution of a set of nanomaterials with defined attributes in naïve and modified livers using chemistry, imaging and biological methods. This work is expected to determine how nanomaterials’ attributes direct pathways for liver cell disposal and describe nanomaterial–liver interactions at the cellular level, information crucial in enabling safer nanomaterials for use in products such as drug formulations, sunscreens and cosmetics.Read moreRead less
Plasticity of gastrointestinal vagal afferents. The aim of this project is to identify how leptin modulates specific subtypes of vagal afferent within the gut and the plasticity of this system under different dietary conditions. This proposed project will substantially increase understanding of the interactions between leptin, known to influence food intake, and vagal afferent satiety signals. It will also increase understanding of how these interactions alter in obesity and ultimately provide t ....Plasticity of gastrointestinal vagal afferents. The aim of this project is to identify how leptin modulates specific subtypes of vagal afferent within the gut and the plasticity of this system under different dietary conditions. This proposed project will substantially increase understanding of the interactions between leptin, known to influence food intake, and vagal afferent satiety signals. It will also increase understanding of how these interactions alter in obesity and ultimately provide targets and/or concepts for the pharmacotherapy of obesity.Read moreRead less
Central pathways regulating visceral pain. This project aims to investigate the neural pathways within the spinal cord and brain processing colorectal pain perception. The project aims to identify the spinal cord neurons relaying colorectal signalling into the brain and the influence of descending modulation from the brainstem upon these pathways. The outcomes will greatly benefit fundamental understanding of the central pathways processing visceral pain.
Function and redundancy of SOX genes in the mammalian sex determination pathway. We are studying a mouse model of abnormal sex organ development in which genetically female mice develop as males. Our basic research program will lead to greater understanding of the genetic switch controlling the formation of male and female characteristics. This research should in turn provide insight into the causes of defects in patients with disorders of sex development, helping to inform the difficult clinica ....Function and redundancy of SOX genes in the mammalian sex determination pathway. We are studying a mouse model of abnormal sex organ development in which genetically female mice develop as males. Our basic research program will lead to greater understanding of the genetic switch controlling the formation of male and female characteristics. This research should in turn provide insight into the causes of defects in patients with disorders of sex development, helping to inform the difficult clinical decisions that need to be made for their treatment, and ultimately leading to better management and therapeutic strategies. Our studies may also provide unique methods to control the exotic mouse population, using the daughterless strategy.Read moreRead less
Bold Experiment: an historical evaluation of the Australian Assistance Plan. Australia and similar western democracies continue to wrestle with growing citizen disengagement with political processes and declining levels of active participation in society. This project is expected to provide the first historical examination of the Australian Assistance Plan (AAP), an innovative yet forgotten program from the 1970s. The AAP sought to reframe participation at a local level, stimulate voluntary orga ....Bold Experiment: an historical evaluation of the Australian Assistance Plan. Australia and similar western democracies continue to wrestle with growing citizen disengagement with political processes and declining levels of active participation in society. This project is expected to provide the first historical examination of the Australian Assistance Plan (AAP), an innovative yet forgotten program from the 1970s. The AAP sought to reframe participation at a local level, stimulate voluntary organisations and provide a framework that engaged with all levels of governments. Using archival sources and oral history methods, the project seeks to offer a new interpretation of an important initiative in Australian history and demonstrate how historical analysis can inform policy and shape debates in government and non-profit sectors in the future.Read moreRead less
Molecular mechanisms regulating Ca2+ channels formed by Orai and STIM proteins. Store-operated calcium channels play a central role in the functions of all animal cells. They participate in generating the cellular responses to hormones, antigens, growth factors and other physiological stimuli. The aims of this project are to elucidate cellular mechanisms that regulate interaction between the molecular components of store-operated calcium channel, Orai and STIM. Using techniques of electrophysiol ....Molecular mechanisms regulating Ca2+ channels formed by Orai and STIM proteins. Store-operated calcium channels play a central role in the functions of all animal cells. They participate in generating the cellular responses to hormones, antigens, growth factors and other physiological stimuli. The aims of this project are to elucidate cellular mechanisms that regulate interaction between the molecular components of store-operated calcium channel, Orai and STIM. Using techniques of electrophysiology and molecular biology we expect to answer a fundamental question how STIM and Orai proteins interact to form functional store-operated calcium channels, and how the expression of STIM and Orai is regulated.Read moreRead less