The N-ICE Trial: A Randomised Controlled Trial Of The Safety And Efficacy Of N-Acetyl Cysteine (NAC) As A Pharmacotherapy For Methamphetamine (“ice”) Dependence
Funder
National Health and Medical Research Council
Funding Amount
$1,551,368.00
Summary
Crystalline methamphetamine (aka ‘ice’) is a significant public health concern in Australia and globally. Currently there are no approved medications to treat methamphetamine dependence. We will trial tN-acetyl-cysteine (NAC) as a medications for methamphetamine dependence.
Pubertal Transitions In Mental Health And Behaviour: The PHASE-A Study Of Social Roleand Lifestyle Transitions
Funder
National Health and Medical Research Council
Funding Amount
$1,656,785.00
Summary
Over the past four decades problems such as depression, anxiety, self-harm and substance abuse have increased in young people. Recent research indicates that puberty is a time when these problems commonly first emerge. This five-year study of 4000 students will examine a question of whether social transitions that are too soon (e.g. early initiation of sex) or problematic (e.g. bullying from peers) may explain the increase in these health problems as children pass through puberty.
An inability to resist a temptation or repeated failures of self-regulation can lead to 'impulsive' and 'compulsive' behaviours that relate to a host of personal and social problems (eg., excessive eating, gambling, and substance use). Despite this, very little research has studied the neural and psychological underpinnings of these behaviours. My research will take advantage of recent innovations and approaches to fill this void and have implications for diagnosis and treatment.
Preventive And Early Intervention Strategies In Emerging Mental Disorders In Young People
Funder
National Health and Medical Research Council
Funding Amount
$2,000,000.00
Summary
The Centre will be developed through the extension of a youth psychiatry clinical research program of international standing across Melbourne and Sydney. The CCRE will have a major impact on the growth and sustainability of clinical research expertise in youth mental health and its translation into clinical practice. Funds will be targeted specifically at two key opportunities in an evolving structure, namely the early career path for emerging young clinical researchers and the need for more inn ....The Centre will be developed through the extension of a youth psychiatry clinical research program of international standing across Melbourne and Sydney. The CCRE will have a major impact on the growth and sustainability of clinical research expertise in youth mental health and its translation into clinical practice. Funds will be targeted specifically at two key opportunities in an evolving structure, namely the early career path for emerging young clinical researchers and the need for more innovative and potent translation of clinical research into the real world of clinical practice. NHMRC CCRE funding will strengthen the ORC initiative by strategically filling gaps in early career development and training, and drive dissemination and translation of research into clinical practice across Australia.Read moreRead less
The R2C Program: A Randomised Controlled Trial Of A Telephone-based Intervention For Alcohol Misuse
Funder
National Health and Medical Research Council
Funding Amount
$727,611.00
Summary
Despite high rates of problem drinking in Australia, few seek help due to stigma and a range of other barriers. In this project, we will conduct a randomised controlled trial to examine the effectiveness of a standalone telephone-delivered intervention, incorporating low-cost, structured, and integrated psychosocial support, to reduce harmful alcohol use and associated psychological morbidity in non-treatment-seeking problem drinkers.
The Construction And Validation Of The Assessment Of Mental Health Related Quality Of Life (PsyQoL) Instrument
Funder
National Health and Medical Research Council
Funding Amount
$539,450.00
Summary
Mental Health is one of the national health priority areas as well as one of the largest contributors to burden of disease. WHO projections suggest that by 2020 the burden of depression alone will be second only to cardiovascular disease. New treatments for mental disorders are being developed which must be evaluated. Current research methods do not allow an accurate comparison of the cost effectiveness of these therapies with the cost effectiveness of other medical services as this requires the ....Mental Health is one of the national health priority areas as well as one of the largest contributors to burden of disease. WHO projections suggest that by 2020 the burden of depression alone will be second only to cardiovascular disease. New treatments for mental disorders are being developed which must be evaluated. Current research methods do not allow an accurate comparison of the cost effectiveness of these therapies with the cost effectiveness of other medical services as this requires the measurement of 'utility' or 'quality of life'. The small number of 'generic' 'quality of life instruments' developed to date vary significantly in their 'sensitivity' to different illnesses-their ability to detect change-and none is very sensitive to changes in mental health states. The present project is to overcome this deficit. This will be achieved by refining and expanding an instrument developed in Australia, the Assessment of Quality of Life (AQoL) instrument. This is the only instrument to date which was both constructed using correct psychometric principles of instrument construction and which describes health states in terms of the effect upon a patient's ability to function in a social environment. The new instrument called the PsyQoL will increase instrument sensitivity by including a mental health 'module' to the existing instrument and revising existing items. The methods used will include several methodological innovations in the description of health states and the derivation of utility scores. The project will include a large scale 'validation' study which will include the construction of population 'norms' and also the creation of 'exchange rates' between the PsyQoL and other instrument scores. The significance of the project is that the PsyQoL will allow valid and reliable measurement of health states in a way that creates a 'level playing field' between mental and other health related interventions.Read moreRead less
Efficacy Of A 3-month Aerobic Exercise Regime For Restoring 'brain Health' In Heavy Cannabis Users
Funder
National Health and Medical Research Council
Funding Amount
$1,209,221.00
Summary
Over a ten-year period, we, and others have documented the brain and psychological harms associated with regular cannabis use. We have now shown that these harms are not permanent, but can be restored. However, the recovery process takes a long time. This study will build on our extensive work to date and, for the first time, investigate whether a specific form of exercise will cause accelerated and beneficial changes in i) the brain and ii) the daily lives of heavy cannabis users.
From neuroscience to society: A multi-disciplinary study of human perception and cognition. This project aims to use a multi-disciplinary approach to investigate the factors influencing human perception and cognition - from the level of basic neuroscience, through to the wider impact felt by individuals and society when these functions are either impaired or enhanced. This will inform the basic research question of how the brain generates a conscious experience, identify the relationship between ....From neuroscience to society: A multi-disciplinary study of human perception and cognition. This project aims to use a multi-disciplinary approach to investigate the factors influencing human perception and cognition - from the level of basic neuroscience, through to the wider impact felt by individuals and society when these functions are either impaired or enhanced. This will inform the basic research question of how the brain generates a conscious experience, identify the relationship between altered visual cognitive function and clinical symptoms of psychosis, and determine the current prevalence and neuroethical issues associated with the non-medical use of drugs to enhance cognitive or perceptual function within Australia.Read moreRead less
Driving Change: Using Emergency Department Data To Reduce Alcohol-related Harm
Funder
National Health and Medical Research Council
Funding Amount
$1,468,026.00
Summary
The proposed project is a system change within partner emergency departments, providing them the information and tools to act on both risky alcohol consumption in individual patients and the sources of alcohol in the community which cause the harm they experience. Most importantly, the proposed public health interventions act as a tool for emergency departments to regularly raise awareness with the public and policymakers regarding the impact of alcohol on patients, clinicians and hospitals.
Improving the retention rate for residential treatment of substance abuse by sequential intervention for social anxiety. Alcohol and other drug use is a major social and medical problem, costing the Australian community an estimated $7.6 billion annually. Mental health disorders have been closely linked with increased illicit drug use and physical health problems. Social anxiety (SAD) is highly prevalent amongst individuals presenting with drug and alcohol use disorders. Evidence suggests that ....Improving the retention rate for residential treatment of substance abuse by sequential intervention for social anxiety. Alcohol and other drug use is a major social and medical problem, costing the Australian community an estimated $7.6 billion annually. Mental health disorders have been closely linked with increased illicit drug use and physical health problems. Social anxiety (SAD) is highly prevalent amongst individuals presenting with drug and alcohol use disorders. Evidence suggests that social anxiety symptoms may be responsible for promoting excessive drug use and may be a particularly influential factor in poor treatment retention rates and promoting relapse. Thus, the focus on improving treatment outcomes for individuals with comorbid anxiety and drug use disorders represents an area of considerable importance both nationally and internationally.Read moreRead less