Application of Silver Coatings to medical Devices for Antimicrobial Properties using Electroless Deposition. Silver compounds, eg. in topical creams, can be used to treat chronic infections. The results are mediocre, and there may be significant side effects. Metallic silver when coated on bandages or medical devices is gaining wider acceptance, but the dissolution rate muct be improved to minimise infection. In this project an electroless silver coating process will be developed, with bath ch ....Application of Silver Coatings to medical Devices for Antimicrobial Properties using Electroless Deposition. Silver compounds, eg. in topical creams, can be used to treat chronic infections. The results are mediocre, and there may be significant side effects. Metallic silver when coated on bandages or medical devices is gaining wider acceptance, but the dissolution rate muct be improved to minimise infection. In this project an electroless silver coating process will be developed, with bath chemistry and coating conditions optimised for an ideal dissolution rate. This project will lead to the development of improved medical devices that will have significant social and economic benefits for Australia.Read moreRead less
TAILORING OF LAYERED DOUBLE HYDROXIDE NANOPARTICLES FOR EFFECTIVE DELIVERY OF BIOLOGICALLY ACTIVE PEPTIDES AND cDNAs. This project will lead to a new class of nanoparticle for effective peptide and DNA transfer, promising efficient drug delivery system with controllable loading and releasing and thus help maintain good health, particularly targeting neurological diseases. This project has also involved fundamental research into the nanomaterial science, surface chemistry, cell biochemistry and n ....TAILORING OF LAYERED DOUBLE HYDROXIDE NANOPARTICLES FOR EFFECTIVE DELIVERY OF BIOLOGICALLY ACTIVE PEPTIDES AND cDNAs. This project will lead to a new class of nanoparticle for effective peptide and DNA transfer, promising efficient drug delivery system with controllable loading and releasing and thus help maintain good health, particularly targeting neurological diseases. This project has also involved fundamental research into the nanomaterial science, surface chemistry, cell biochemistry and neuron sciences. Successful completion of the project will contribute to the development of advanced materials helping Australia advance and build the industrial competitiveness. Through this project highly skilled researchers will be well trained. Read moreRead less
Manipulation of Nano-Scale Assembly, Structure and Interaction: New Drug Delivery Vehicles and Energy Storage Devices for Miniaturised Portable Electronic Products. Nano-scale molecular and surface interactions will be manipulated to develop new nano-structured products. There will be two themes of research activity. In the first theme, newly discovered ionic liquids will be employed to better elucidate the role of hydrophobic interaction in molecular assembly processes. These findings wil ....Manipulation of Nano-Scale Assembly, Structure and Interaction: New Drug Delivery Vehicles and Energy Storage Devices for Miniaturised Portable Electronic Products. Nano-scale molecular and surface interactions will be manipulated to develop new nano-structured products. There will be two themes of research activity. In the first theme, newly discovered ionic liquids will be employed to better elucidate the role of hydrophobic interaction in molecular assembly processes. These findings will assist in the development of surfactant-drug conjugates that can self-assemble and can converge therapeutic, drug delivery and controlled release functions; allowing drugs to be administered in the therapeutic concentration range for prolonged periods of time with reduced side-effects. In the second theme, nano-materials will be used to converge capacitor and battery technologies to provide a dramatic performance boost to miniaturised portable electronic devices.Read moreRead less
Fluorous Chemistry: New tagging agents and heterocyclic-based fluorous surfactants. Fluorous chemistry is emerging as a powerful adjunct to areas of conventional parallel and combinatorial organic syntheses, and its introduction has revolutionised separation technologies. In this project two new fluorous tagging strategies will be investigated in an effort to broaden the scope of reagents that can used in synthesis. Efforts will be directed to chiral auxiliaries and to fluorous catalyst ligands. ....Fluorous Chemistry: New tagging agents and heterocyclic-based fluorous surfactants. Fluorous chemistry is emerging as a powerful adjunct to areas of conventional parallel and combinatorial organic syntheses, and its introduction has revolutionised separation technologies. In this project two new fluorous tagging strategies will be investigated in an effort to broaden the scope of reagents that can used in synthesis. Efforts will be directed to chiral auxiliaries and to fluorous catalyst ligands. In addition, a novel class of fluorous surfactant will be investigated, for its surface properties (including its ability to self assemble) and for its utility in two specific applications, selective membrane-bound protein extraction (relevant to proteomics) and ophthalmics (biomaterials).Read moreRead less
Nanotherapeutics: nanoparticles with high specificity for the delivery and controlled release of drugs. This technology will deliver therapeutic drugs and/or MRI contrast agents to individual diseased cells with very high specificity and selectivity. The cells can be interogated to determine when they are "loaded" and the site of the "loaded" cells precisely determined. Drugs can be released photochemically. The administered dosage can be decreased with no loss of efficacy, and side effects re ....Nanotherapeutics: nanoparticles with high specificity for the delivery and controlled release of drugs. This technology will deliver therapeutic drugs and/or MRI contrast agents to individual diseased cells with very high specificity and selectivity. The cells can be interogated to determine when they are "loaded" and the site of the "loaded" cells precisely determined. Drugs can be released photochemically. The administered dosage can be decreased with no loss of efficacy, and side effects reduced. Read moreRead less
Nano-Particle Suspension Behaviour in Salt Solutions: Effect of Ion Hydration and Attractive Forces. Understanding and controlling the flow behaviour of nano-particle suspensions is crucial to the processing of ceramics with nano-scale features. Interparticle forces influence the flow behaviour and depend upon the the adsorption of ions to the particle's surface. The proposed research investigates the effect of ion hydration and surface type on ion adsorption, the resulting attractive forces a ....Nano-Particle Suspension Behaviour in Salt Solutions: Effect of Ion Hydration and Attractive Forces. Understanding and controlling the flow behaviour of nano-particle suspensions is crucial to the processing of ceramics with nano-scale features. Interparticle forces influence the flow behaviour and depend upon the the adsorption of ions to the particle's surface. The proposed research investigates the effect of ion hydration and surface type on ion adsorption, the resulting attractive forces and suspension flow behaviour. The outcomes of the project have potential for significant increase in fundamental understanding of the relationship between ions, surfaces and forces. The benefits of this knowledge include producing nano-ceramics with improved properties and better understanding biopolymer behaviour.Read moreRead less
Interfacial Studies of Nanoparticulate Dendrimers for Improved BioPharmaceutical Application. Dendrimers are a novel class of nanoparticles with exciting potential as pharmaceuticals for the prevention of major disease states, e.g. viral and cancer. A colloid and interfacial chemistry approach will be employed to develop an understanding of the mechanisms for the solution to cell transport processes and for optimisation of formulation strategies for delivery vehicles. Significant advances in t ....Interfacial Studies of Nanoparticulate Dendrimers for Improved BioPharmaceutical Application. Dendrimers are a novel class of nanoparticles with exciting potential as pharmaceuticals for the prevention of major disease states, e.g. viral and cancer. A colloid and interfacial chemistry approach will be employed to develop an understanding of the mechanisms for the solution to cell transport processes and for optimisation of formulation strategies for delivery vehicles. Significant advances in the development of novel pharmaceutical products will result, with significant social and economic benefits nationally and internationally.Read moreRead less
Particles at Interfaces—Controlling Detachment. Small, solid particles affect the processes used by the Australian mining industry to recover precious metals and valuable minerals in ways that remain poorly understood. The outcomes of this project will make significant contributions to the fundamental understanding of the role of particles in emulsions and foams. The results will also ultimately transfer to, and have a substantial impact on, the pharmaceutical industry, which is poised to use na ....Particles at Interfaces—Controlling Detachment. Small, solid particles affect the processes used by the Australian mining industry to recover precious metals and valuable minerals in ways that remain poorly understood. The outcomes of this project will make significant contributions to the fundamental understanding of the role of particles in emulsions and foams. The results will also ultimately transfer to, and have a substantial impact on, the pharmaceutical industry, which is poised to use nanotechnology to revolutionise drug delivery.Read moreRead less
Mechanisms of enhancement of absorption of poorly water-soluble drugs from the gastrointestinal tract mediated by lipids, surfactants and polymers. This project will provide technological advances with significant benefits in terms of improved drug treatment, and therefore health outcomes for Australia. The projects builds on internationally recognised research strengths at Monash University in lipid-based drug delivery, and connects Monash and Australia with applied research in the multination ....Mechanisms of enhancement of absorption of poorly water-soluble drugs from the gastrointestinal tract mediated by lipids, surfactants and polymers. This project will provide technological advances with significant benefits in terms of improved drug treatment, and therefore health outcomes for Australia. The projects builds on internationally recognised research strengths at Monash University in lipid-based drug delivery, and connects Monash and Australia with applied research in the multinational pharmaceutical industry. This will enhance the standing of Australian biomedical research in the pharmaceutical world and directly facilitate a partnership between Monash and Capsugel in commercialisation of the outcomes of the project. The project will also train Australian scientists in skills that are in great demand in the developing pharmaceutical industry in Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0345760
Funder
Australian Research Council
Funding Amount
$210,000.00
Summary
Nanoscale Interaction Forces in Particulate and Molecular Systems. We seek to establish a world-class facility for the measurement of nanoscale interaction forces. The ability to measure forces between particles, polymers, emulsion droplets, bubbles, proteins and powders will augment our research capabilities in minerals and material processing, thin film technology, structured surfaces, and in molecular and bio-technology (eg. proteins, DNA, cells, bone, bio-implants). A Molecular Force Probe ....Nanoscale Interaction Forces in Particulate and Molecular Systems. We seek to establish a world-class facility for the measurement of nanoscale interaction forces. The ability to measure forces between particles, polymers, emulsion droplets, bubbles, proteins and powders will augment our research capabilities in minerals and material processing, thin film technology, structured surfaces, and in molecular and bio-technology (eg. proteins, DNA, cells, bone, bio-implants). A Molecular Force Probe (Asylum Research) instrument will allow precise and flexible force measurements on the nano-metre scale. The proposed multi-disciplinary facility will advance research in the areas of engineering, chemistry, pharmacology and biotechnology.
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