One of the current challenges in public health is to translate the progress from the Human Genome Project into reduced morbidity and mortality from disease. Once genetic defects are characterised, knowledge about the variability in severity of disease in mutation carriers, is important from a public health perspective. Hereditary Haemochromatosis (HH) is a common genetic disorder of iron overload that results in a wide spectrum of disease, varying from non-specific symptoms to severe damage to l ....One of the current challenges in public health is to translate the progress from the Human Genome Project into reduced morbidity and mortality from disease. Once genetic defects are characterised, knowledge about the variability in severity of disease in mutation carriers, is important from a public health perspective. Hereditary Haemochromatosis (HH) is a common genetic disorder of iron overload that results in a wide spectrum of disease, varying from non-specific symptoms to severe damage to liver, heart, pancreas and joints from iron deposition. It is easily treatable by regular blood donation, and population-based screening for HH has therefore been advocated. In this study we aim to address gaps in the existing data on HH regarding dietary and lifestyle factors that contribute to the variable clinical picture of HH. The study will be based on the Melbourne Collaborative Cohort Study, a cohort of 31,500 men and women who have been followed for approximately 10 years. Information on dietary and lifestyle factors was collected at initial enrollment, along with a blood specimen. We will test all non-Southern European participants (31,176) for the common HH mutations in the HFE gene and then select a subgroup of 1150 people, including all people with the main genetic defect as well as a comparison group, for further clinical followup. Participants will have genetic counselling and informed consent will be obtained. Participants will complete a short questionnaire and give a blood sample for measurement of iron overload, liver function, and other relevant blood tests, then undergo a brief clinical examination. Results of all tests will be given at a followup visit by genetic counsellor or physician. This study will provide important data on natural history of HH risk factors that influence variability in clinical presentation and the association of HFE mutations with chronic diseases and all cause mortality.Read moreRead less
Melanoma is one of Australia?s major cancer problems, but we still do not completely understand why certain people are at higher risk than others. This study is focussed on people who have developed melanoma at an early age (under 40yrs) and will compare their family history of cancer, skin features, genetic characteristics and various aspects of their previous sun exposure with people who don?t have melanoma. The large number of people involved and the fact that they will be selected at random ....Melanoma is one of Australia?s major cancer problems, but we still do not completely understand why certain people are at higher risk than others. This study is focussed on people who have developed melanoma at an early age (under 40yrs) and will compare their family history of cancer, skin features, genetic characteristics and various aspects of their previous sun exposure with people who don?t have melanoma. The large number of people involved and the fact that they will be selected at random from the population of Melbourne, Sydney and Brisbane which have very different melanoma rates, means that the study will be able to clarify what roles genes and environment play in the disease. It is intended to be an international benchmark in this regard, and Australia is the only country in which a study of this scope could be mounted. Potential benefits from this research will be a better understanding of the way sun exposure affects people differently, depending on their genetic makeup, the place of genetic testing in assessing people?s risk of melanoma, particularly if they have relatives with the disease, and way in which skin features like moles should be taken into account in that assessment. Finally, it is likely that better information about the types of genetic susceptibility to melanoma in the population will translate to more effective programs for the prevention of melanoma and for detection of melanomas efficiently at the earliest possible stage.Read moreRead less
Cancer And Low-dose Radiation - Possible Effects Of CT Scans In Childhood
Funder
National Health and Medical Research Council
Funding Amount
$476,650.00
Summary
Despite 100 years of research there is uncertainty about effects of low dose radiation from background and medical X-rays. We will measure the incidence of cancer in Australians exposed to CT scans (medical X-rays) as children between 1985 and 2005. Our results, from follow-up to 2009, will show whether there is a small but signicantly increased risk of cancer and guide further improvement in radiation safety standards if these prove to be necessary.
Genes And Environment In The Risk Of Early Age-Related Macular Degeneration: A Population-based Case-Control Study
Funder
National Health and Medical Research Council
Funding Amount
$949,588.00
Summary
This study will pool data from three well-conducted population-based cohorts of older persons to gain a large sample size in order to investigate the interplay of genes and environmental factors on the risk of age-related macular degeneration (AMD). The study will give insights into AMD pathogenesis, and enable potential targeting of people with AMD susceptibility genes for preventive approaches. These could ultimately reduce the burden of this blinding condition.
Men, Women And Ageing: Predictors Of Ageing Well In The Australian Longitudinal Study On Womens Health And The Perth He
Funder
National Health and Medical Research Council
Funding Amount
$1,935,634.00
Summary
Maintaining health and independent living are high priorities for Australia’s rapidly expanding older population. This project capitalizes on two existing large-scale studies, to increase our scientific understanding of strategies for maintaining the health and wellbeing of older people living in the community. Two separate longitudinal research projects, the Australian Longitudinal Study on Women’s Health involving over 12,000 older women selected from every part of Australia, and the Health in ....Maintaining health and independent living are high priorities for Australia’s rapidly expanding older population. This project capitalizes on two existing large-scale studies, to increase our scientific understanding of strategies for maintaining the health and wellbeing of older people living in the community. Two separate longitudinal research projects, the Australian Longitudinal Study on Women’s Health involving over 12,000 older women selected from every part of Australia, and the Health in Men Study involving over 12,000 older men from Perth, Western Australia, have been following older Australians in order to determine what contributes to older people’s health and quality of life. The new project will combine data from these two studies. The two projects contain a breadth of data and can address the following questions: What health-related, personal, lifestyle and social factors predict survival and healthy non-disabled life in men and women aged 70-90 years? Do changes in lifestyle in older age (eg smoking cessation) affect length and quality of life? Who makes greatest use of health services, and who least, and how does this relate to health outcomes?How are health and lifestyle factors related to social connectedness and independent living in older age? What health and lifestyle factors predict positive mental health in older age? How are older men’s and women’s lifestyles and health status different, and how are they the same? Should health promotion programs in old age target men and women separately, or not?Read moreRead less
Familial, Behavioural And Environmental Determinants Of Respiratory And Metabolic Fitness In Regional South Australia.
Funder
National Health and Medical Research Council
Funding Amount
$287,321.00
Summary
South Australia is the fattest state in Australia. Limited health surveillance data suggests that Whyalla is fatter, less active, consumes more alcohol and has worse respiratory health than Adelaide. Obesity is linked to poorer respiratory health. Public concern over the effects of air pollution on the health of Whyalla families has prompted us to examine respiratory and metabolic health in Whyalla families in comparison to those in the north-west suburbs of Adelaide.
Trials To Prevent The Transmission And Complications Of Sexually Transmitted Infections, Including HIV
Funder
National Health and Medical Research Council
Funding Amount
$306,123.00
Summary
Sexually transmitted infections (STIs) are important causes of illness in some sectors of the community. Even though they can be effectively prevented and treated, many health services do not give them priority. This research project will study ways in which general practitioners can better diagnose and treat STIs. We will carry out trials that compare new approaches to supporting doctors in this area, that involve a mixture of training, reminders and technical support as needed.
Explaining Social Inequality In Population Oral Health Using A Multilevel Approach
Funder
National Health and Medical Research Council
Funding Amount
$103,500.00
Summary
Our preliminary research demonstrated a social gradient in the oral health of Australian adults. Adults who occupy higher positions on the social hierarchy experienced less disease and symptom experience, enhanced quality of life, and better self-rated oral health. Not only were associations made between social position and oral health, but a range of other factors such as personal control, social support, stress, life satisfaction, and workplace and childhood social environments were also assoc ....Our preliminary research demonstrated a social gradient in the oral health of Australian adults. Adults who occupy higher positions on the social hierarchy experienced less disease and symptom experience, enhanced quality of life, and better self-rated oral health. Not only were associations made between social position and oral health, but a range of other factors such as personal control, social support, stress, life satisfaction, and workplace and childhood social environments were also associated with oral wellness. This work is new Australian research and is yet to be published. In an expansion of this project, we move from describing oral health inequalities and identifying their social determinants to provide a better understanding of pathways to population oral health. In doing so we shift the focus from the individual to the social context in which individuals live. We suggest that characteristics of social environments contribute independently to the variation in oral health outcomes accounted for by the characteristics of the residents themselves. In particular, we seek to demonstrate that social cohesion (the social integration, trust, and reciprocity within an area) influences conditions linked to oral health. Previous research has demonstrated variation in health according to area. Such studies are able to demonstrate a clustering of health, but are not able to distinguish whether observed social patterns in health reflect characteristics of residents or some feature of the area itself. Such conclusions require multilevel statistical models designed to separate individual effects from contextual effects while simultaneously examining interactions between both levels. Oral health is ideally suited as a proxy for general health because of the ubiquity of dental diseases, the broad utilisation of dental services within the population, and the shared risk factors between oral disease and a wide range chronic health conditions.Read moreRead less
Genes And Environment In Late AMD: Pooling A State And Population Resource
Funder
National Health and Medical Research Council
Funding Amount
$701,642.00
Summary
This study will pool cases from the West Australian Macular Degeneration database with the Blue Mountains Eye Study (NSW), to investigate the interplay of genes and environmental factors on risk of age-related macular degeneration (AMD), in particular the late, vision threatening stage. It will provide insights into the underlying causes of AMD, and could allow us to target people with AMD susceptibility genes for preventive approaches, which could reduce the burden of this disease.