Investigating the dynamic nature of antibody stability. The aim of the project is to provide insights into the molecular mechanisms of antibody stability. Monoclonal antibodies have transformed the study of biological processes and represent blockbuster therapeutics for cancer and inflammation. Unfortunately, antibodies often display limited stability, which greatly hinders development. Mutations have recently been identified that render human antibodies resistant to aggregation, and high-resolu ....Investigating the dynamic nature of antibody stability. The aim of the project is to provide insights into the molecular mechanisms of antibody stability. Monoclonal antibodies have transformed the study of biological processes and represent blockbuster therapeutics for cancer and inflammation. Unfortunately, antibodies often display limited stability, which greatly hinders development. Mutations have recently been identified that render human antibodies resistant to aggregation, and high-resolution crystal structures are being used to identify function. Intriguingly, preliminary data indicates that the mutations do not affect the native antibody structure, but rather influence dynamic states. The project plans to use a combination of mutagenesis, molecular dynamics simulation and deuterium exchange to study antibody dynamics.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0211003
Funder
Australian Research Council
Funding Amount
$125,000.00
Summary
A Facility for Probing Nanostructure in Polymers. The properties of a polymer are only partly determined by its molecular structure. It is now clear that the organization of molecular structure and phase morphology on a nano-scale has an equally important role in determining material behaviour. Increasingly this can be manipulated by judicious choice of formulation and processing variables. The polymer Nano-Structure Facility will bring together Australia's principal polymer experts in this a ....A Facility for Probing Nanostructure in Polymers. The properties of a polymer are only partly determined by its molecular structure. It is now clear that the organization of molecular structure and phase morphology on a nano-scale has an equally important role in determining material behaviour. Increasingly this can be manipulated by judicious choice of formulation and processing variables. The polymer Nano-Structure Facility will bring together Australia's principal polymer experts in this area of structure-property relations and provide them with shared access to the appropriate, modern analytical tools required to probe the nano-structure of such new materials with enhanced properties.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100195
Funder
Australian Research Council
Funding Amount
$1,000,000.00
Summary
Field-emission gun transmission electron microscope for the research in nanomaterials, metal alloys and biological sciences. The proposed facility is required by a large range of world-leading research programs in light metals, nanomaterials, fibres and biomaterials. These research programs are strongly supported by automobile, textile, mineral and advanced materials industries that have important roles in the current national economy and local communities. The facility will improve significan ....Field-emission gun transmission electron microscope for the research in nanomaterials, metal alloys and biological sciences. The proposed facility is required by a large range of world-leading research programs in light metals, nanomaterials, fibres and biomaterials. These research programs are strongly supported by automobile, textile, mineral and advanced materials industries that have important roles in the current national economy and local communities. The facility will improve significantly our current research ability and help the creation of new research areas in nanotechnology and energy materials beneficial to clean energy, environmental protections and health care. It is also important equipment for new research student training.Read moreRead less
Fatigue Life Prediction of Nano-filler Modified Composites. The proposed project aims to study the behaviour and the failure mechanisms of polymer nanocomposites under cyclic loading. The outcomes of the project will make original contributions to our knowledge base on such materials. The mechanics modelling and statistical analysis of the prediction of fatigue life will provide a sound physical basis and a useful tool for any future improvement and optimisation of the composites to achieve bett ....Fatigue Life Prediction of Nano-filler Modified Composites. The proposed project aims to study the behaviour and the failure mechanisms of polymer nanocomposites under cyclic loading. The outcomes of the project will make original contributions to our knowledge base on such materials. The mechanics modelling and statistical analysis of the prediction of fatigue life will provide a sound physical basis and a useful tool for any future improvement and optimisation of the composites to achieve better reliability and integrity in their intended applications. This study will bring economic benefits to the end-users of advanced material technology including the Australian materials industries. Read moreRead less
High-Performance Polymer Composites for Electrical Discharging. This project aims to address the problem of electrostatic discharge by developing new industry-compatible processing techniques and taking advantage of the synergy between graphene and carbon nanotubes and fibres. Electrostatic discharge due to accumulation of static electricity is a significant problem for lightweight polymer composites used in hazard environments, such as pumps for underground mining, oil and gas storage and satel ....High-Performance Polymer Composites for Electrical Discharging. This project aims to address the problem of electrostatic discharge by developing new industry-compatible processing techniques and taking advantage of the synergy between graphene and carbon nanotubes and fibres. Electrostatic discharge due to accumulation of static electricity is a significant problem for lightweight polymer composites used in hazard environments, such as pumps for underground mining, oil and gas storage and satellites. The outcomes will potentially transform the current manufacturing practice of anti-static composites for industry applications including mining, energy, space and agriculture. Read moreRead less
Novel barrier products: synthesis design using controlled radical polymerization in dispersed systems. Personal barrier products (eg surgical and industrial rubber gloves) are currently manufactured using emulsion polymerization synthesis methods that have evolved little in 50 years. A dramatic new method for controlling polymer architecture, developed by a team led by the CI and Dulux for paints, also has the potential to tailor-make barrier products, from less hazardous raw materials. This pro ....Novel barrier products: synthesis design using controlled radical polymerization in dispersed systems. Personal barrier products (eg surgical and industrial rubber gloves) are currently manufactured using emulsion polymerization synthesis methods that have evolved little in 50 years. A dramatic new method for controlling polymer architecture, developed by a team led by the CI and Dulux for paints, also has the potential to tailor-make barrier products, from less hazardous raw materials. This project commences the fundamental research for understanding the mechanisms involved in using this method with butadiene, and the mechanical properties of the resulting novel block copolymers. This science would later be applied by the industrial partner to significantly improve their barrier products.Read moreRead less
Mid-Career Industry Fellowships - Grant ID: IM230100154
Funder
Australian Research Council
Funding Amount
$1,049,904.00
Summary
Fungi Power: Designer Fungal Cell Factories for Advanced Biomanufacturing. This project aims to build an advanced biomanufacturing platform based on filamentous fungi in collaboration with industry. Using synthetic biology, the project expects to engineer superior fungal host strains customisable to the needs of the industry and to address their technological gaps. The expected outcomes include the development of cost-efficient and sustainable fungal-based bioprocesses for the companies to produ ....Fungi Power: Designer Fungal Cell Factories for Advanced Biomanufacturing. This project aims to build an advanced biomanufacturing platform based on filamentous fungi in collaboration with industry. Using synthetic biology, the project expects to engineer superior fungal host strains customisable to the needs of the industry and to address their technological gaps. The expected outcomes include the development of cost-efficient and sustainable fungal-based bioprocesses for the companies to produce products, such as fine chemicals, pharmaceutical actives and food ingredients. The project would provide significant benefits by enabling existing and emerging companies' commercial successes and competitiveness in global markets, creating new jobs and resulting in the growth of the bio-economy in Australia.Read moreRead less
Toughening thermosets by highly ordered nanostructures. This research will develop a new technology to manufacture a class of novel ordered nanostructured thermosets. The outcome of this project will enable many existing and new engineering applications in the transportation, construction and microelectronics industries in Australia.
ARC Centre of Excellence in Synthetic Biology. The ARC Centre of Excellence in Synthetic Biology (CoESB) will provide the technical innovation critical for Australia to develop a vibrant bioeconomy building on the nation’s strengths in agriculture. For thousands of years we have used microbes to create bread, wine, cheese. Now, our Centre will pioneer new approaches to the design of synthetic microbes, enabling the development of custom-designed microbial communities, synthetic organelles and ne ....ARC Centre of Excellence in Synthetic Biology. The ARC Centre of Excellence in Synthetic Biology (CoESB) will provide the technical innovation critical for Australia to develop a vibrant bioeconomy building on the nation’s strengths in agriculture. For thousands of years we have used microbes to create bread, wine, cheese. Now, our Centre will pioneer new approaches to the design of synthetic microbes, enabling the development of custom-designed microbial communities, synthetic organelles and new to nature biological pathways and enzymes. CoESB will combine engineering with molecular biology to design and construct novel biological systems that can convert biomass from agriculture or waste streams to biofuel, bioplastics and other high-value chemicals.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0883017
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Advanced processing and characterisation facility for functional polymers and polymer nanofibres. The pilot-scale processing and advanced characterisation facility will significantly strengthen R&D capacity for innovative research and development of functional polymers and polymer nanofibres, hence adding value to the $10-billion plus market for plastics, rubber and biopolymers manufactured and used in Australia. It will further strengthen Australia's position in polymer and nanofibre research a ....Advanced processing and characterisation facility for functional polymers and polymer nanofibres. The pilot-scale processing and advanced characterisation facility will significantly strengthen R&D capacity for innovative research and development of functional polymers and polymer nanofibres, hence adding value to the $10-billion plus market for plastics, rubber and biopolymers manufactured and used in Australia. It will further strengthen Australia's position in polymer and nanofibre research and innovation.Read moreRead less