Identifying The Pathological Mechanism Of PCDH19-Girls Clustering Epilepsy
Funder
National Health and Medical Research Council
Funding Amount
$523,988.00
Summary
Changes in the PCDH19 gene are a relatively common cause of epilepsy. To better understand the basis of this disorder, we have developed unique mouse models that mimic the genetic changes and symptoms of this condition. We will perform careful analysis of brain development in these models to determine the primary cause of this condition. These experiments will create greater understanding of how changes in PCDH19 cause epilepsy in girls and facilitate the development of new treatments.
Understanding The Causes Of Childhood Congenital Anomalies Of The Kidney And Urinary Tract
Funder
National Health and Medical Research Council
Funding Amount
$609,748.00
Summary
Congenital anomalies of the kidney and urinary tract (CAKUT) is a common cause of renal failure in children. The majority of patients with CAKUT do not know the underlying cause of their renal anomalies. In this proposal we will characterise the developmental events that are perturbed in three mouse models of CAKUT and identify the causal gene responsible in each mouse model. We will translate this information to the clinic by screening patients with CAKUT for mutations in these newly identified ....Congenital anomalies of the kidney and urinary tract (CAKUT) is a common cause of renal failure in children. The majority of patients with CAKUT do not know the underlying cause of their renal anomalies. In this proposal we will characterise the developmental events that are perturbed in three mouse models of CAKUT and identify the causal gene responsible in each mouse model. We will translate this information to the clinic by screening patients with CAKUT for mutations in these newly identified genes.Read moreRead less
Information Systems Enabled Corporate Transformation: Evaluation of Electronic Customer Relationship Management in the Service Sector. Customer relationship management (CRM) is a business and marketing strategy that integrates technology, process and business activities around the customer. Only 30% of electronic CRM efforts have been successfully implemented because stakeholder expectations are typically neglected. This issue underlines the importance of the ?soft? organisational issues involve ....Information Systems Enabled Corporate Transformation: Evaluation of Electronic Customer Relationship Management in the Service Sector. Customer relationship management (CRM) is a business and marketing strategy that integrates technology, process and business activities around the customer. Only 30% of electronic CRM efforts have been successfully implemented because stakeholder expectations are typically neglected. This issue underlines the importance of the ?soft? organisational issues involved with the evaluation of information systems. By evaluating the change management process and modelling the impact of e-CRM enabled change, management strategies will be developed to enable its successful implementation. The research will provide a greater understanding for evaluating the performance of e-CRM solutions, as well as uncover opportunities for organisational related change.Read moreRead less
Strategic evaluation model for business-to-business electronic marketplace participation. Striving to become a knowledge-based nation is dependent upon the effective adoption, diffusion and implementation of ICT throughout the business community. The developing world markets, brought about by e-commerce and the increased ability to trade globally facilitated by e-markets, have created significant opportunities for Australian organisations. This research will produce a dynamic model that can be ....Strategic evaluation model for business-to-business electronic marketplace participation. Striving to become a knowledge-based nation is dependent upon the effective adoption, diffusion and implementation of ICT throughout the business community. The developing world markets, brought about by e-commerce and the increased ability to trade globally facilitated by e-markets, have created significant opportunities for Australian organisations. This research will produce a dynamic model that can be used to not only evaluate e-marketplace participation but a wide range of Internet applications. The research will provide Australian managers with the foundation of knowledge needed to guide and support their decision-making when implementing new technology.Read moreRead less
Dynamic Life Cycle Evaluation of Customer Relationship Management Systems. Striving to become a knowledge based nation is dependent upon effective adoption, diffusion and implementation of information and communication technology thoughout the business community. This research will produce a dynamic model that can be used to evaluate enterprise wide applications such as electronic Customer Relationship Management (CRM) so that managers can examine the impact of new tehnology on business processe ....Dynamic Life Cycle Evaluation of Customer Relationship Management Systems. Striving to become a knowledge based nation is dependent upon effective adoption, diffusion and implementation of information and communication technology thoughout the business community. This research will produce a dynamic model that can be used to evaluate enterprise wide applications such as electronic Customer Relationship Management (CRM) so that managers can examine the impact of new tehnology on business processes. In addition, the research will provide managers wit the foundation of knowledge needed to guide and support their decision-making when implementing new technology. Read moreRead less
Classifying the indirect costs of information systems and information technology in business. Many businesses are increasing their expenditure on IS/IT to obtain a strategic competitive advantage. Traditional approaches to IS/IT appraisal are unable to accommodate the costs associated with deploying 'organisational-wide' IS/IT solutions because of their qualitative characteristics. The inability of managers to determine the 'true' costs of IS/IT are attributable to a lack of knowledge and unders ....Classifying the indirect costs of information systems and information technology in business. Many businesses are increasing their expenditure on IS/IT to obtain a strategic competitive advantage. Traditional approaches to IS/IT appraisal are unable to accommodate the costs associated with deploying 'organisational-wide' IS/IT solutions because of their qualitative characteristics. The inability of managers to determine the 'true' costs of IS/IT are attributable to a lack of knowledge and understanding of IS/IT related costs. This research will extend the myopia of traditional 'direct' financial cost analysis by identifying 'indirect' cost factors. A model that integrates cost taxonomies and performance measures/metrics of IS/IT will be developed as a frame of reference for IS/IT decision-makers.Read moreRead less
Designing an Intelligent Process Operation Management System. The complexity and sophistication of current generation of industrial processes, and the growing need for autonomous agents that control physical systems, motivate the need for the development of an intelligent process operation management system. In this project, the innovative integration of theories from different scientific fields (computer systems, process engineering, systems and control engineering) provides an excellent platfo ....Designing an Intelligent Process Operation Management System. The complexity and sophistication of current generation of industrial processes, and the growing need for autonomous agents that control physical systems, motivate the need for the development of an intelligent process operation management system. In this project, the innovative integration of theories from different scientific fields (computer systems, process engineering, systems and control engineering) provides an excellent platform for development of a smart data management tool, to oversee the major operational tasks within the plant and help the operators and engineers to make more informed decisions. Direct application of the techniques developed in this study to a pilot case study, could be used as a benchmark to show the potential benefits that can be gained through smart information use and data management.Read moreRead less
FINANCIAL (IN)SECURITY IN LATER LIFE: WOMEN, WORK , SUPERANNUATION AND AUSTRALIA'S RETIREMENT INCOME SYSTEM. An ageing population is expected to contribute to significant demographic, social and labour market shifts, which, together with fiscal stresses, will affect the future mix of state and private retirement income provisions. However, gender-based issues associated with these changes remain under-researched. Using a life-course approach qualitative methodologies will be used to explore inte ....FINANCIAL (IN)SECURITY IN LATER LIFE: WOMEN, WORK , SUPERANNUATION AND AUSTRALIA'S RETIREMENT INCOME SYSTEM. An ageing population is expected to contribute to significant demographic, social and labour market shifts, which, together with fiscal stresses, will affect the future mix of state and private retirement income provisions. However, gender-based issues associated with these changes remain under-researched. Using a life-course approach qualitative methodologies will be used to explore inter-relationships between: women's workforce participation, education, marital status, fertility, financial literacy; retirement incomes;concessions, benefits; and women's economic security in later years. The research will make a significant contribution to the development and implementation of retirement income policy and the debate on gender equity in the labour market. Read moreRead less
Special Research Initiatives - Grant ID: SR0354729
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Smart Use of Information Technologies (SUITs). The SUITs network will develop critical mass in world-class, leading-edge research into the smart use of information and communication technology (ICT) through integration of research within the dispersed Australian ICT research community and through facilitating international linkages. The network will undertake research applicable in key sectors including the health, education, service, knowledge and media industries. The aim is to establish a h ....Smart Use of Information Technologies (SUITs). The SUITs network will develop critical mass in world-class, leading-edge research into the smart use of information and communication technology (ICT) through integration of research within the dispersed Australian ICT research community and through facilitating international linkages. The network will undertake research applicable in key sectors including the health, education, service, knowledge and media industries. The aim is to establish a higher order of coordination and collaboration in research into ICT applications.
The feasibility study proposed will engage key stakeholders, refine research goals and investigate linkage mechanisms to improve Australia's ICT research and its contribution to economic and social well-being.
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Improving organisational innovation using social media. This project will examine how social media can be effectively used in organisations to improve levels of innovation. The outcomes of the research will put Australia at the forefront of research in the area and have a significant impact on innovation in Australian organisations.