Exploiting the lymphatic system for next generation vaccine development . Vaccination is the most successful and cost-effective means of combating infectious diseases. This project will look at how vaccine adjuvants work and will help the development of new vaccines against infections in both animals and man. It will also promote the training of Australian scientists in the field of vaccine research and development.
Exploring the immunomodulatory potential of Natural Killer T cells. Natural Killer T cells (NKT cells) are an innate-like population of T cells that recognise a range of lipid based antigens when bound to the antigen-presenting molecule, CD1d. Once activated, NKT cells rapidly secrete a variety of cytokines. This project, in partnership with Vaxine Pty Ltd, aims to gain a basic understanding of NKT recognition of lipids and NKT cell activation by lipids. The project aims to use a combination of ....Exploring the immunomodulatory potential of Natural Killer T cells. Natural Killer T cells (NKT cells) are an innate-like population of T cells that recognise a range of lipid based antigens when bound to the antigen-presenting molecule, CD1d. Once activated, NKT cells rapidly secrete a variety of cytokines. This project, in partnership with Vaxine Pty Ltd, aims to gain a basic understanding of NKT recognition of lipids and NKT cell activation by lipids. The project aims to use a combination of cellular immunology and structural biology to gain insight into NKT cell agonism.Read moreRead less
Dissecting the physiology of multipotent mesenchymal stromal cells to develop vaccine candidates for respiratory disease. The project aims to gain an understanding of how a type of adult stem cell inhibits immune responses that cause asthma. The project will produce new stem cell products and facilitate the design of a vaccine for asthma and other respiratory diseases, which would greatly reduce the burden of such conditions.
Enhanced multivalent vaccine responses using a novel vaccine vector system. Enhanced multivalent vaccine responses using a novel vaccine vector system. This project aims to develop a multicomponent vaccine system to deliver equal effectiveness against several disease targets in a single administration. New and innovative vaccine design strategies incorporating economical commercial production processes are urgently needed for new and existing human and animal health applications. A vaccine capab ....Enhanced multivalent vaccine responses using a novel vaccine vector system. Enhanced multivalent vaccine responses using a novel vaccine vector system. This project aims to develop a multicomponent vaccine system to deliver equal effectiveness against several disease targets in a single administration. New and innovative vaccine design strategies incorporating economical commercial production processes are urgently needed for new and existing human and animal health applications. A vaccine capable of targeting multiple diseases by a single injection is an obvious way to expedite future vaccine development and deployment. However, the recipient’s immune system can repress equivalent responses to these multicomponent vaccines. This project’s research is expected to address these problems, and underpin the future commercial development of this vaccine platform.Read moreRead less
Cellulosic and paper-based biosensors for blood analysis. Testing the blood compatibility of an Australian evacuated for surgery; measuring the iron content from India for anemia treatment; identifying the outbreak of malaria in Pakistan; measuring prostate specific antigen/blood screening in your home. These are novel applications for paper biosensors, which will improve health and create new jobs in Australia.
Programming Paradigms, Tools and Algorithms for Electronic Structure Calculations on Clusters of Non-Uniform Memory Access Parallel Processors. In recent years Australian academia has invested heavily in high performance computing systems. A significant fraction of these resources are devoted to performing computational chemistry studies, such as those used in drug design. This project links Australian researchers with the company responsible for a particularly widely used computational chemistr ....Programming Paradigms, Tools and Algorithms for Electronic Structure Calculations on Clusters of Non-Uniform Memory Access Parallel Processors. In recent years Australian academia has invested heavily in high performance computing systems. A significant fraction of these resources are devoted to performing computational chemistry studies, such as those used in drug design. This project links Australian researchers with the company responsible for a particularly widely used computational chemistry application package, and also with a major international computer company. Our aim is to substantially improve the performance of this code on cluster based compute systems. This, as well as our generic performance evaluation tools, would be of substantial benefit to the Australian research community. The project will forge links with researchers in Singapore, Japan and the USA.Read moreRead less
The Development of Creative Thinking Ability in TAFE Design Students. The aim is to develop an instructional framework as a conceptual basis for instruction aimed at TAFE design student use of imagery in creative thinking. The research addresses the challenges of recent post-compulsory education initiatives, which include a more specific focus on the development of creative problem-solving skills, but provide little guidance on instructional strategies. The research will synthesise the framewo ....The Development of Creative Thinking Ability in TAFE Design Students. The aim is to develop an instructional framework as a conceptual basis for instruction aimed at TAFE design student use of imagery in creative thinking. The research addresses the challenges of recent post-compulsory education initiatives, which include a more specific focus on the development of creative problem-solving skills, but provide little guidance on instructional strategies. The research will synthesise the framework from theories about cognitive processes, creative problem-solving and the use of mental imagery; and the results of an imagery training program and creative problem-solving interventions. The outcome will be an instructional framework for guiding the development of student creative thinking in design-based courses in TAFE.Read moreRead less
The development of a potent new passive immunotherapeutic for the treatment and prevention of bacterial sepsis and septic shock. Bacterial sepsis and septic shock is a leading cause of death in hospital intensive care units and represents a significant public health burden. By developing a new passive immunotherapeutic regimen to treat and prevent bacterial sepsis and septic shock, the project aims to reverse the significant mortality and morbidity associated with this condition.
Psychological User Profiling in the Telecommunications Industry. Recording user behaviour allows businesses to learn about their customers. This is particularly important in telecommunications, since the core business involves a large number of users who vary considerably from one another. This project combines psychological insights with modern statistical methods to develop a psychologically plausible user profiling framework, accounting for the idiosyncratic usage patterns of customers, and t ....Psychological User Profiling in the Telecommunications Industry. Recording user behaviour allows businesses to learn about their customers. This is particularly important in telecommunications, since the core business involves a large number of users who vary considerably from one another. This project combines psychological insights with modern statistical methods to develop a psychologically plausible user profiling framework, accounting for the idiosyncratic usage patterns of customers, and the way in which they change over time. The profiles will be tied to marketing prospects through interviews and surveys. Applied benefits include the ability to predict, understand and act upon user behaviour. The project also adds substantially to theories of memory, individual differences and decision-making.Read moreRead less
An investigation of memory functioning of the prefrontal cortex. This project aims to investigate the role of the prefrontal cortex in human memory. While the medial temporal lobe has long been recognised as imperative for basic memory processes, the prefrontal cortex has only recently been recognised to mediate higher-level strategic memory processes. This project will clarify the memory functions of the dorsolateral, orbitofrontal, and medial prefrontal lobes by studying performance of individ ....An investigation of memory functioning of the prefrontal cortex. This project aims to investigate the role of the prefrontal cortex in human memory. While the medial temporal lobe has long been recognised as imperative for basic memory processes, the prefrontal cortex has only recently been recognised to mediate higher-level strategic memory processes. This project will clarify the memory functions of the dorsolateral, orbitofrontal, and medial prefrontal lobes by studying performance of individuals with damage in these areas using memory tests and tasks. Our findings will enhance understanding and theorising of the neural basis of memory and have implications for management and rehabilitation of memory impairments in brain injured individuals.Read moreRead less