Cellular Plasticity in the Brain: discovering molecular mechanisms controlling the production of neurons during brain development, function, ageing and disease. The program aims to understand the mechanisms regulating Brain Plasticity - this recently discovered property of the brain to respond to environmental stimuli, both physiological and pathological, by producing new functional neurons. Specifically, the program will discover how the brain's stem cells are stimulated to produce new neurons. ....Cellular Plasticity in the Brain: discovering molecular mechanisms controlling the production of neurons during brain development, function, ageing and disease. The program aims to understand the mechanisms regulating Brain Plasticity - this recently discovered property of the brain to respond to environmental stimuli, both physiological and pathological, by producing new functional neurons. Specifically, the program will discover how the brain's stem cells are stimulated to produce new neurons. This understanding will significantly expand our knowledge of how the brain develops, and how functions, like memory, are modulated by neuronal replacement. Discoveries will underpin the development of, in association with Australia's biotechnology sector, a new generation of therapeutics, which treat neurological diseases, like Stroke, by stimulating the production of functional neurons.Read moreRead less
Stimulus fear-relevance: Exploring the boundaries of preferential attentional processing. The present project will contribute to our knowledge about the manner in which emotionally salient events are processed. It will test predictions from a current, influential theory of anxiety and in doing so, inform our understanding of information processing in psychopathology. Investigation of these basic questions can have implications for the design of therapeutic interventions. Moreover, the presen ....Stimulus fear-relevance: Exploring the boundaries of preferential attentional processing. The present project will contribute to our knowledge about the manner in which emotionally salient events are processed. It will test predictions from a current, influential theory of anxiety and in doing so, inform our understanding of information processing in psychopathology. Investigation of these basic questions can have implications for the design of therapeutic interventions. Moreover, the present project will provide the opportunity for research training for undergraduate and post graduate students. In doing so, it will enhance the quality of our culture and contribute to the discipline of psychology.Read moreRead less
Testing the ghost with the machine: Empirical investigations of cognition using high-field functional magnetic resonance imaging. The primary aim of the project is to test hypotheses about the cognitive architecture of word production and negative priming using high-field functional magnetic resonance imaging (fMRI). Additional aims/outcomes are to apply a novel fMRI acquisition sequence that permits overt verbal responding with rapid presentation of trials and collection of the time course of t ....Testing the ghost with the machine: Empirical investigations of cognition using high-field functional magnetic resonance imaging. The primary aim of the project is to test hypotheses about the cognitive architecture of word production and negative priming using high-field functional magnetic resonance imaging (fMRI). Additional aims/outcomes are to apply a novel fMRI acquisition sequence that permits overt verbal responding with rapid presentation of trials and collection of the time course of the blood oxygen level dependent (BOLD) signal, and to further develop a methodology that delineates the logic of making inferences about cognitive systems from functional neuroimaging data. These represent potentially significant developments in the fields of cognitive neuroscience and functional neuroimaging.Read moreRead less
Mechanisms of fear learning and extinction in the mammalian brain. The brain is a remarkable machine that coordinates all aspects of our daily lives including the storage and retrieval of memories. Given that many age-related degenerative disorders are associated with marked changes in learning and memory it also has implications for Australia's National Research Priority 2 "Ageing well and ageing productively". This research aims to discover the basic mechanisms that underlie memory storage an ....Mechanisms of fear learning and extinction in the mammalian brain. The brain is a remarkable machine that coordinates all aspects of our daily lives including the storage and retrieval of memories. Given that many age-related degenerative disorders are associated with marked changes in learning and memory it also has implications for Australia's National Research Priority 2 "Ageing well and ageing productively". This research aims to discover the basic mechanisms that underlie memory storage and how these are modulated in an emotional context. It will also shed light on states such as anxiety, depression and post-traumatic stress, enhancing our ability to identify new therapeutic targets for such disorders.Read moreRead less
How Stenolemus Assassin Bugs Crack Spider Codes. This unique study of sophisticated behavioural flexibility and dynamic sensory exploitation in an insect will provide novel insights into how simple cognitive architecture can be used to solve complex problems. These insights are important for the development of artificial intelligence systems. This will be the first study of flexible aggressive mimicry in an insect and will attract considerable international attention, raise the profile of Austra ....How Stenolemus Assassin Bugs Crack Spider Codes. This unique study of sophisticated behavioural flexibility and dynamic sensory exploitation in an insect will provide novel insights into how simple cognitive architecture can be used to solve complex problems. These insights are important for the development of artificial intelligence systems. This will be the first study of flexible aggressive mimicry in an insect and will attract considerable international attention, raise the profile of Australian science and support numerous students. We will make the first use in Australia of state-of-the-art vibration recording and interactive playback techniques. Making these powerful experimental tools available in Australia will enable other many additional innovative lines of research.Read moreRead less
Dissecting a hematopietic transcription factor complex. The development of mature active cells is a highly complex and coordinated process that is controlled largely by groups of interacting regulatory proteins. We are trying to understand, at a very detailed level, how a specific group of these proteins interact to regulate both normal blood cell development and the onset of childhood leukemias. Using this information we will try to develop reagents that can be used to inhibit these interaction ....Dissecting a hematopietic transcription factor complex. The development of mature active cells is a highly complex and coordinated process that is controlled largely by groups of interacting regulatory proteins. We are trying to understand, at a very detailed level, how a specific group of these proteins interact to regulate both normal blood cell development and the onset of childhood leukemias. Using this information we will try to develop reagents that can be used to inhibit these interactions and be used as lead compounds for treatments for disease.Read moreRead less
Investigating the activator function of the Bim protein. Apoptosis is a research area where Australia has had long standing success. The first observations of this important process were made by Prof John Kerr in the 60's and 70's. A molecular renaissance developed in the late 80's and has led to the current explosion in this area of research. Many of these recent studies have been conducted at the Walter and Eliza Hall Institute. Our scientific endeavour is aimed at broadening the understanding ....Investigating the activator function of the Bim protein. Apoptosis is a research area where Australia has had long standing success. The first observations of this important process were made by Prof John Kerr in the 60's and 70's. A molecular renaissance developed in the late 80's and has led to the current explosion in this area of research. Many of these recent studies have been conducted at the Walter and Eliza Hall Institute. Our scientific endeavour is aimed at broadening the understanding of the mechanisms of cell death using genetically modified mouse models. Insights gained through this project will have far reaching implications for the design of new drugs to combat cancer and degenerative diseases.Read moreRead less
Oxidative Damage and Cell Ageing. This research will benefit Australia by providing a fundamental understanding of how cells age. This will have immediate international impact at the scientific level and will inform strategies to reduce the rate of ageing and alleviation of age-related disorders. In the longer term the research may provide commercial and social outcomes by identifying antioxidant systems that will provide a genuine benefit in reducing ageing.
Cellular Responses to Oxidative Damage: Cell Aging. The aim of this project is to identify the mechanisms by which oxidative stress and free radical damage cause cell aging. This work will make a significant contribution to our understanding of the aging process in cells by identifying the major reactive oxygen species that contribute to cell aging, which defence systems and antioxidants provide the greatest degree of protection, what damage accumulates as cells age and which genetic systems ar ....Cellular Responses to Oxidative Damage: Cell Aging. The aim of this project is to identify the mechanisms by which oxidative stress and free radical damage cause cell aging. This work will make a significant contribution to our understanding of the aging process in cells by identifying the major reactive oxygen species that contribute to cell aging, which defence systems and antioxidants provide the greatest degree of protection, what damage accumulates as cells age and which genetic systems are activated as during the process.Read moreRead less
Regulation of lipolysis: new players, new paradigms. The way in which fat is broken down is poorly understood. This research will determine how important proteins in fat breakdown are turned on and off. By understanding this relationship, effective pharmaceutical treatments will be developed that will enhance the capacity to burn fat and ultimately reduce the incidence of type 2 diabetes and cardiovascular disease, and ease the associated financial burden on the community and healthcare system. ....Regulation of lipolysis: new players, new paradigms. The way in which fat is broken down is poorly understood. This research will determine how important proteins in fat breakdown are turned on and off. By understanding this relationship, effective pharmaceutical treatments will be developed that will enhance the capacity to burn fat and ultimately reduce the incidence of type 2 diabetes and cardiovascular disease, and ease the associated financial burden on the community and healthcare system. Understanding fat breakdown is also important for developing new processing technologies in the food industry.Read moreRead less