Exploiting the lymphatic system for next generation vaccine development . Vaccination is the most successful and cost-effective means of combating infectious diseases. This project will look at how vaccine adjuvants work and will help the development of new vaccines against infections in both animals and man. It will also promote the training of Australian scientists in the field of vaccine research and development.
Exploring the immunomodulatory potential of Natural Killer T cells. Natural Killer T cells (NKT cells) are an innate-like population of T cells that recognise a range of lipid based antigens when bound to the antigen-presenting molecule, CD1d. Once activated, NKT cells rapidly secrete a variety of cytokines. This project, in partnership with Vaxine Pty Ltd, aims to gain a basic understanding of NKT recognition of lipids and NKT cell activation by lipids. The project aims to use a combination of ....Exploring the immunomodulatory potential of Natural Killer T cells. Natural Killer T cells (NKT cells) are an innate-like population of T cells that recognise a range of lipid based antigens when bound to the antigen-presenting molecule, CD1d. Once activated, NKT cells rapidly secrete a variety of cytokines. This project, in partnership with Vaxine Pty Ltd, aims to gain a basic understanding of NKT recognition of lipids and NKT cell activation by lipids. The project aims to use a combination of cellular immunology and structural biology to gain insight into NKT cell agonism.Read moreRead less
Robust face detection and recognition for computer-based security surveillance. The research aims at improving the existing and creating new automated face detection and recognition methods by making them invariant, firstly to head pose, orientation, scale and rotation, and then to occlusion, lighting conditions and facial expressions.
A robust face detector will be developed first and then a new face recognition algorithm that continues to learn identity-specific discriminants on-line by co ....Robust face detection and recognition for computer-based security surveillance. The research aims at improving the existing and creating new automated face detection and recognition methods by making them invariant, firstly to head pose, orientation, scale and rotation, and then to occlusion, lighting conditions and facial expressions.
A robust face detector will be developed first and then a new face recognition algorithm that continues to learn identity-specific discriminants on-line by collecting incremental face exemplars. The result of the research will be an algorithm that can improve its performance on-line adapting in a stable learning process each identity model to the correct facial examples.
The research has significant practical implication in visual surveillance increasing the robustness of identification of person identity, state and intent.
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Intruder alert! detecting and classifying events in noisy time series. This project aims to address the mathematical challenges in automated early detection and classification of intrusion events in noisy time series generated from perimeter security systems. The project expects to develop robust methods to detect intrusion events under different operating environments while ignoring nuisance events. The project will boost the global competitiveness of the Australian security industry, and enabl ....Intruder alert! detecting and classifying events in noisy time series. This project aims to address the mathematical challenges in automated early detection and classification of intrusion events in noisy time series generated from perimeter security systems. The project expects to develop robust methods to detect intrusion events under different operating environments while ignoring nuisance events. The project will boost the global competitiveness of the Australian security industry, and enable improved event detection and classification in noisy time series to the benefit of many critical application areas beyond national security.Read moreRead less
Non-Contact In-process Shape Measurement of Windscreens. Optical techniques have been widely used for non-contact measurement of the 3-D shape of diffusely reflecting surfaces. However, there is no evidence for the successful implementation of a real-time shape measurement system for large specular surfaces, despite the many important industrial applications. The aim of this project is to develop optically-based techniques to measure the shape of specular and transparent surfaces in real time in ....Non-Contact In-process Shape Measurement of Windscreens. Optical techniques have been widely used for non-contact measurement of the 3-D shape of diffusely reflecting surfaces. However, there is no evidence for the successful implementation of a real-time shape measurement system for large specular surfaces, despite the many important industrial applications. The aim of this project is to develop optically-based techniques to measure the shape of specular and transparent surfaces in real time in an industrial environment. The main outcome of the research will be a prototype on-line shape measurement system to control the quality of car windscreens.Read moreRead less
Privacy-preserving cloud data mining-as-a-service. This project aims to explore practical privacy-preserving solutions for cloud data mining-as-a-service based on the Intel Software Guard Extensions (SGX) technology. The research addresses privacy concerns of users when outsourcing data mining needs to the cloud. These concerns have increased as more businesses evaluate data mining-as-an outsourced service due to lack of expertise or computation resources. The expected outcomes from the research ....Privacy-preserving cloud data mining-as-a-service. This project aims to explore practical privacy-preserving solutions for cloud data mining-as-a-service based on the Intel Software Guard Extensions (SGX) technology. The research addresses privacy concerns of users when outsourcing data mining needs to the cloud. These concerns have increased as more businesses evaluate data mining-as-an outsourced service due to lack of expertise or computation resources. The expected outcomes from the research will include new data privacy models, new privacy-preserving data mining algorithms, and a prototype of cloud data mining software. These will help businesses cut costs for data mining and privacy protection, and provide significant benefits toward helping Australia achieve its national cyber security strategy and potentially provide economic impact from commercialisation of new software technology for the industry partner.Read moreRead less
Methodologies for automatic visual identification in heat detection aids. New techniques will be designed and developed to automate the existing manual heat detection of cattle, under general imaging conditions. The proposed intelligent system will consist of six stages: 1- image acquisition, 2- image preprocessing, 3- presence detection, 4- illumination compensation, 5- HD detection, and 6- heat detection. The proposed system will handle various image variations, and will be fast and cost-effec ....Methodologies for automatic visual identification in heat detection aids. New techniques will be designed and developed to automate the existing manual heat detection of cattle, under general imaging conditions. The proposed intelligent system will consist of six stages: 1- image acquisition, 2- image preprocessing, 3- presence detection, 4- illumination compensation, 5- HD detection, and 6- heat detection. The proposed system will handle various image variations, and will be fast and cost-effective. The developed system will improve the productivity of Australian cattle industry.Read moreRead less
Dissecting the physiology of multipotent mesenchymal stromal cells to develop vaccine candidates for respiratory disease. The project aims to gain an understanding of how a type of adult stem cell inhibits immune responses that cause asthma. The project will produce new stem cell products and facilitate the design of a vaccine for asthma and other respiratory diseases, which would greatly reduce the burden of such conditions.
Cellulosic and paper-based biosensors for blood analysis. Testing the blood compatibility of an Australian evacuated for surgery; measuring the iron content from India for anemia treatment; identifying the outbreak of malaria in Pakistan; measuring prostate specific antigen/blood screening in your home. These are novel applications for paper biosensors, which will improve health and create new jobs in Australia.
New techniques for modelling, diagnosis and counter measures for cardiac related sleep disordered breathing. Around 50% of congestive heart failure sufferers have some form of sleep disordered breathing. However, little has been done so far to simultaneously monitor, analyse and treat the two conditions. Therefore, this project proposes to develop new technology incorporating mathematical models for heart rate variability, considering the links between sleep disordered breathing and cardiovasc ....New techniques for modelling, diagnosis and counter measures for cardiac related sleep disordered breathing. Around 50% of congestive heart failure sufferers have some form of sleep disordered breathing. However, little has been done so far to simultaneously monitor, analyse and treat the two conditions. Therefore, this project proposes to develop new technology incorporating mathematical models for heart rate variability, considering the links between sleep disordered breathing and cardiovascular disease. This innovation will enable, for the first time, a device capable of accurate and reliable diagnosis of various sleep disorders using only conventional ECG data. Such technology has the potential to produce significant community health benefits, and save several millions of lives worldwide.Read moreRead less