A specialised set of T lymphocytes called Mucosal Associated Invariant T (MAIT) cells react against bacteria and yeast, and reside at mucosal sites where the body's immune defences are most easily breached, e.g. respiratory tract and intestinal mucosa. This study investigates the role of MAIT cells in both protection and pathology in bacterial infections. Controlling MAIT cells could help in treating these conditions.
Antigen Presentation, Recognition And The Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$14,927,045.00
Summary
This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of techniques to dissect the function of various immune cell types and to explore the relationship between structure and function of important cell surface molecules. These studies will improve our ability to design new generation vaccines for combating infectious diseases, controlling cancer, or limiting autoimmune or inflammatory diseases.
Robust speech recognition in realistic hostile environments. Australia leads the world in the adoption of speech recognition technology but sadly lags in the development of the fundamental advances in the area. This research will help propel Australia to the forefront of new innovations in speech recognition technology and contributions to fundamental science. Our project will provide an excellent training ground for graduate students and researchers, with the real possibility of significant com ....Robust speech recognition in realistic hostile environments. Australia leads the world in the adoption of speech recognition technology but sadly lags in the development of the fundamental advances in the area. This research will help propel Australia to the forefront of new innovations in speech recognition technology and contributions to fundamental science. Our project will provide an excellent training ground for graduate students and researchers, with the real possibility of significant commercial benefit to the nation. The deployment of our system in the community will greatly enhance the defence and police forces ability for surveillance and security, and will provide new assistive aids to improve the quality of life and safety for the elderly and disabled.Read moreRead less
A Structural Investigation Into The T-cell Response To Epstein Barr Virus Infection
Funder
National Health and Medical Research Council
Funding Amount
$549,000.00
Summary
X-ray crystallography is an essential tool for solving the three-dimensional structure of proteins. Proteins control the biological processes within the cell and it is the precise shape of proteins that determines how they function. Depending on the particular sequence of the amino acids, the so-called building unit of the proteins, the protein molecule bends and forms a distinct, complex shape. This specific three-dimensional shape allows the protein to undertake its specific function, such as ....X-ray crystallography is an essential tool for solving the three-dimensional structure of proteins. Proteins control the biological processes within the cell and it is the precise shape of proteins that determines how they function. Depending on the particular sequence of the amino acids, the so-called building unit of the proteins, the protein molecule bends and forms a distinct, complex shape. This specific three-dimensional shape allows the protein to undertake its specific function, such as binding to other proteins, acting as an enzyme or interacting with nucleic acids. To determine how a protein acts, it is vital to know the precise three-dimensional shape at the atomic level. This proposal is concerned with understanding the precise shape of proteins that control the immune response to Epstein Barr Virus. Epstein Barr Virus is an ubiquitous human pathogen that has being linked to a number of cancers. This work will further our understanding of the immune response to Epstein Barr Virus.Read moreRead less
Antigen Presentation, Recognition And The Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$15,780,848.00
Summary
This program focuses on understanding the development of immune response to viruses and other infectious agents using a broad array of techniques to dissect the function of various immune cell types and to explore the relationship between structure and function of important cell surface molecules. These studies will improve our ability to design new generation vaccines for combating infectious diseases, controlling cancer, or limiting autoimmune diseases like diabetes.
The Relationship Between Cancer Surgery, Lymph Nodes, T Cells And Immunotherapy.
Funder
National Health and Medical Research Council
Funding Amount
$960,585.00
Summary
Cancer treatment involves surgery for millions of patients annually, however, many patients do relapse. Surgery often involves removal of cancer-associated lymph nodes at the site. To improve surgical outcomes new immunotherapy strategies aim to activate the patients’ immune cells to eradicate tumours. However the main repository for these immune cells is in the very lymph tissue removed at surgery. This project will investigate the role of remaining lymph nodes in patient recovery/response.
Surviving the data deluge: Scalable feature extraction, discrimination and analysis for computer vision tasks using compressed sensed data. Strategically, our pioneering solutions besides being technically and socially significant, open fresh options for sensor-agnostic data analysis. The technical significance lies through the creation of new technologies for the critical national and global security markets, currently overwhelmed by data. The social significance arises from our solutions being ....Surviving the data deluge: Scalable feature extraction, discrimination and analysis for computer vision tasks using compressed sensed data. Strategically, our pioneering solutions besides being technically and socially significant, open fresh options for sensor-agnostic data analysis. The technical significance lies through the creation of new technologies for the critical national and global security markets, currently overwhelmed by data. The social significance arises from our solutions being privacy preserving, providing new avenues for the production of novel, socially acceptable products for aged care monitoring. Our methods spearhead future advancement in diverse disciplines due to the wide applicability of the methods to other sensor networks (Square Kilometre Array) and data types, providing new frameworks for addressing crucial problems of data management. Read moreRead less