Characterisation Of Two Novel Markers Of Osteosarcoma Metastasis As Potential Therapeutic Targets
Funder
National Health and Medical Research Council
Funding Amount
$624,500.00
Summary
Osteosarcoma (OS) is the most common bone tumour in children and adolescents. In spite of aggressive chemotherapy, OS tumours that metastasise to the lungs result in dismal long-term survivals of only 10-20%. For these patients, new treatment options are desperately needed. In this proposal we show compelling data identifying two new markers of OS metastasis. This research aims to validate the suitability of these novel markers as therapeutic targets to prevent OS metastasis.
Special Research Initiatives - Grant ID: SR0354638
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Innovative science for sustainable use of marine biodiversity goods and services. Development of new scientific tools and technologies provide expanded opportunities for marine biological research in Australia. An urgent need is to coordinate research scientists and institutions to ensure maximum benefits and to meet Australia's obligations under UNCLOS. The primary goal of this proposed Network is to develop research programs of international significance, through the establishment of new teams ....Innovative science for sustainable use of marine biodiversity goods and services. Development of new scientific tools and technologies provide expanded opportunities for marine biological research in Australia. An urgent need is to coordinate research scientists and institutions to ensure maximum benefits and to meet Australia's obligations under UNCLOS. The primary goal of this proposed Network is to develop research programs of international significance, through the establishment of new teams of Australia's leading marine scientists, mathematical modelers and economists that transcend traditional disciplinary, institutional and geographic boundaries. Our goal is to add focus, scale and scope to an enduring program of innovative research development, leading to world leadership in marine resource management.Read moreRead less
How does allocation to each sex evolve in hermaphrodites? New insight from the sea. Understanding the ability of hermaphroditic animals to adapt their sex allocation to suit environmental conditions will pave the way for integration between pure and applied research. Such understanding can provide stakeholders across a range of disciplines (natural resource management, aquaculture, conservation) with key information about genetic and environmental influences on the reproduction of many species o ....How does allocation to each sex evolve in hermaphrodites? New insight from the sea. Understanding the ability of hermaphroditic animals to adapt their sex allocation to suit environmental conditions will pave the way for integration between pure and applied research. Such understanding can provide stakeholders across a range of disciplines (natural resource management, aquaculture, conservation) with key information about genetic and environmental influences on the reproduction of many species of significant ecological, economic and social value with this mating system. This research will yield knowledge at the very forefront of evolutionary ecology, enhancing Australia's reputation for research excellence in this field, and further benefit Australian science through the training of young scientists.Read moreRead less