Understanding and reversing the habitat shifts that have endangered the broad-headed snake. Extinction rates for vertebrate species are higher in southern Australia than almost anywhere else in the world, and saving endangered taxa is critical to biodiversity conservation. To do this effectively, researchers need to understand the processes that threaten wild populations, and to develop novel solutions to those problems in close collaboration with wildlife management authorities and other stake ....Understanding and reversing the habitat shifts that have endangered the broad-headed snake. Extinction rates for vertebrate species are higher in southern Australia than almost anywhere else in the world, and saving endangered taxa is critical to biodiversity conservation. To do this effectively, researchers need to understand the processes that threaten wild populations, and to develop novel solutions to those problems in close collaboration with wildlife management authorities and other stakeholders. This project will build such an understanding and collaboration, focusing on an endangered snake species. We propose ambitious landscape-scale field experiments that will simultaneously test hypotheses on threatening processes, and restore habitat quality to reverse population declines.Read moreRead less
Capture stress and post-capture survival of sharks and other chondrichthyans in fisheries bycatch. Australia is adopting ecosystem approaches to fisheries management. However, to embrace such an approach there is an urgent need for better information on the biology, ecology and population dynamics of sharks, rays and chimaeras (class Chondrichthyes). Chondrichthyan species are among the most sensitive in their response to the effects of fishing. Results from the present proposal will contribute ....Capture stress and post-capture survival of sharks and other chondrichthyans in fisheries bycatch. Australia is adopting ecosystem approaches to fisheries management. However, to embrace such an approach there is an urgent need for better information on the biology, ecology and population dynamics of sharks, rays and chimaeras (class Chondrichthyes). Chondrichthyan species are among the most sensitive in their response to the effects of fishing. Results from the present proposal will contribute to determining mortality of chondrichthyan bycatch species in response to the effects of capture in fishing gear, handling by fishers and discarding at sea. The work will contribute to biodiversity conservation and maintenance of ecosystem structure and function for present and future generations.Read moreRead less
Cellular genomic approach to the pathogenesis of multiple sclerosis. This project compares the levels of gene usage in two important immune cell types between patients with multiple sclerosis and people who do not have the disease. It aims to identify the molecular basis for the disease, in order to identify new diagnostic, preventative and treatment options.
Biophysical identification of natural human antibody targets. A natural human antibody, PAT-SM6, isolated using technology developed by the partner organisation (Patrys), offers promise as a therapy to reduce mortalities due to cancer, the leading cause of death in Australia. The novelty of the approach pioneered by Patrys is the direct production of human antibodies which avoids undesirable side effects associated with the use of antibodies containing non-human components. This project is to ....Biophysical identification of natural human antibody targets. A natural human antibody, PAT-SM6, isolated using technology developed by the partner organisation (Patrys), offers promise as a therapy to reduce mortalities due to cancer, the leading cause of death in Australia. The novelty of the approach pioneered by Patrys is the direct production of human antibodies which avoids undesirable side effects associated with the use of antibodies containing non-human components. This project is to discover the specificity of PAT-SM6 for proteins and protein complexes and how these interactions lead to tumour cell death. This work will enhance the effectiveness of human antibody therapies and help in the development of this fast growing area within the biotechnology industry in Australia.Read moreRead less
Bilateral Cochlear Implants for Children: Does a Second Implant Improve Language, Psychosocial and Other Outcomes? Severe-profound congenital hearing loss engenders significant costs to society. In 2005, specialised education cost -- on average $25,000 per child, loss of productivity cost -- $6.7 billion, and social security benefits were paid to approximately 129,000 individuals who were unemployed due to hearing loss. If bilateral cochlear implantation results in improved language, social dev ....Bilateral Cochlear Implants for Children: Does a Second Implant Improve Language, Psychosocial and Other Outcomes? Severe-profound congenital hearing loss engenders significant costs to society. In 2005, specialised education cost -- on average $25,000 per child, loss of productivity cost -- $6.7 billion, and social security benefits were paid to approximately 129,000 individuals who were unemployed due to hearing loss. If bilateral cochlear implantation results in improved language, social development, and academic outcomes, the community benefits arising will be greatly improved quality of life for these individuals and significant savings to society. In partnership with Cochlear Ltd, this study will provide some of the first data worldwide comparing the effects of an additional implant on language, social and educational outcomes.Read moreRead less
Development of the PD GeneChip: a research and diagnostic tool for Parkinson's disease. The PD GeneChip will provide both social and economic benefits to Australia. It will be a key research platform for Australian scientists, and will facilitate collaboration both within Australia and overseas. It will assist with health care management of PD (Parkinson's disease) patients by providing a cost-effective diagnostic tool and the possibility of predicting the clinical course of disease. This inform ....Development of the PD GeneChip: a research and diagnostic tool for Parkinson's disease. The PD GeneChip will provide both social and economic benefits to Australia. It will be a key research platform for Australian scientists, and will facilitate collaboration both within Australia and overseas. It will assist with health care management of PD (Parkinson's disease) patients by providing a cost-effective diagnostic tool and the possibility of predicting the clinical course of disease. This information will provide the basis for tailoring treatment to a patients needs. It is anticipated that marketing of the PD GeneChip within Australia and overseas may produce revenue of at least $40 million annually.Read moreRead less
Hazard identification, risk assessment and decision analysis for conservation and management of Australian marine parks. Victoria is the first jurisdiction in the world to proclaim an entire system of marine protected areas at once. The new management responsibilities have created imperatives for robust, scientifically defendable approaches to identifying threats, setting management priorities and developing monitoring systems. This project will develop, for the first time, a risk assessment pro ....Hazard identification, risk assessment and decision analysis for conservation and management of Australian marine parks. Victoria is the first jurisdiction in the world to proclaim an entire system of marine protected areas at once. The new management responsibilities have created imperatives for robust, scientifically defendable approaches to identifying threats, setting management priorities and developing monitoring systems. This project will develop, for the first time, a risk assessment protocol that has due regard for the perception of risks by individuals, and ensures that stakeholder values are an intrinsic part of decision-making. The protocol will create a system that stays faithful to the priorities of those who bear the risks, while using technical methods to ensure that models are consistent and that monitoring provides pertinent information.Read moreRead less
Generating a targeted mutation resource in zebrafish. How do genes function to build organisms and how are they regulated to produce organs and tissues? Using a new technique to target specific genes in the genome of zebrafish, this project will determine how genes control formation of different tissues. The new gene "knockout" technology will fundamentally change our understanding of how genes work during development.
Improving Employment Outcomes in Early Psychosis: Social and Economic Benefits of Early Intervention. Over 74% of people with psychotic illnesses like schizophrenia, despite wanting to work, are unemployed, more than any other disability group. This project examines an evidence-based method in which young people with psychosis can be effectively supported to return to the competitive labour market. In Australia, unemployment of people with schizophrenia costs $927 million, over half the total il ....Improving Employment Outcomes in Early Psychosis: Social and Economic Benefits of Early Intervention. Over 74% of people with psychotic illnesses like schizophrenia, despite wanting to work, are unemployed, more than any other disability group. This project examines an evidence-based method in which young people with psychosis can be effectively supported to return to the competitive labour market. In Australia, unemployment of people with schizophrenia costs $927 million, over half the total illness costs of schizophrenia. For people with psychosis, unemployment exacerbates social and economic marginalisation. This project aims to reduce the economic cost of unemployment among the mentally ill as well as using employment to reduce social marginalisation of people with mental illness.Read moreRead less
Developing technologies that support the genetic modification of rats. Rats and the mouse play critical roles in medical research. Until recently, the targeted genetic modification of a mammal was limited to the mouse. This was due to a technology that was unique to the mouse: embryonic stem (ES) cells. These cells have not been isolated from any other species. The recent development of animal cloning allows for an alternate strategy for targeting genes. We propose to develop cloning strate ....Developing technologies that support the genetic modification of rats. Rats and the mouse play critical roles in medical research. Until recently, the targeted genetic modification of a mammal was limited to the mouse. This was due to a technology that was unique to the mouse: embryonic stem (ES) cells. These cells have not been isolated from any other species. The recent development of animal cloning allows for an alternate strategy for targeting genes. We propose to develop cloning strategies in the rat that supports the genetic modification of this animal. The development of this technology will bring considerable benefits to the areas of physiological research and drug design.Read moreRead less