Indigenous Network Suicide Intervention Skills Training (INSIST): Can A Community Designed And Delivered Framework Reduce Suicide/self-harm In Indigenous Youth?
Funder
National Health and Medical Research Council
Funding Amount
$828,215.00
Summary
Queensland has the highest rates of youth suicide in Australia. Indigenous youth suicide rates are reported at twice the rate of Queensland’s total population for 15 to 44 years. Statistical data on urban-rural differences in Australia have only been available since 1986 (ABS, 1994). Although the number of suicides is far greater in urban areas (1,299 suicides aged 10–24 years in metropolitan areas versus 311 in towns with populations less than 4,000), rural demonstrate greater suicide rates per
The Effect Of Stress And Hypercortisolaemia On Limbic Epileptogenesis & Affective Disorder.
Funder
National Health and Medical Research Council
Funding Amount
$380,714.00
Summary
This project has the potential to provide novel insights about the causal connections between stress, psychiatric illness (specifically anxiety and depression) and temporal lobe epilepsy (TLE) - the most common form of medical refractory epilepsy in the community. Up to 50% of patients with TLE suffer from anxiety and-or depression. Until relatively recently it had been widely assumed that this was a consequence of the chronic epileptic condition. However, recent evidence suggests that there is ....This project has the potential to provide novel insights about the causal connections between stress, psychiatric illness (specifically anxiety and depression) and temporal lobe epilepsy (TLE) - the most common form of medical refractory epilepsy in the community. Up to 50% of patients with TLE suffer from anxiety and-or depression. Until relatively recently it had been widely assumed that this was a consequence of the chronic epileptic condition. However, recent evidence suggests that there is a bi-directional relationship, with the psychiatric conditions and stress also acting to aggravate the seizures and even predispose to the development of the epilepsy itself. Apart from gaining insights into causes of TLE, anxiety and depression, this framework has potential public health relevance suggesting approaches to the eventual primary and secondary prevention of both MTLE and its associated psychiatric co-morbidities, a neglected area at present. The use of an animal model allows investigation of aetiological processes that extend over the lifetime, which is exceptionally difficult to achieve in humans. Retrospective studies, such as case-control studies, although an indispensable research methods, are subject to bias and imprecision when it comes to measuring remote past exposures to stress, abuse, and deprivation. If the results of these experiments are consistent with our hypotheses, a very strong case would exist for exploring this relationship in human studies. The data would also provide a strong rationale for more aggressive detection and treatment of these psychiatric co-morbidities in TLE patients, in order to potentially modify the progression of the disorder as well as improve the quality of life of sufferers. The results of intervention studies in animal models may suggest specific mode of treatment to achieve this.Read moreRead less
A Randomised Controlled Trial Of Low-dose Ketamine In Youth With Severe Depression And Elevated Suicide Risk
Funder
National Health and Medical Research Council
Funding Amount
$2,232,757.00
Summary
Recent research has shown that a single injection of low-dose ketamine has powerful, though short-lived, antidepressant effects. Effective treatments are urgently needed for young people with severe depression. This will be the first controlled study to test whether repeated doses of ketamine, given over 4 weeks, is effective for young patients.
Why Does Early Life Stress Aggravate Limbic Epileptogenesis?
Funder
National Health and Medical Research Council
Funding Amount
$540,116.00
Summary
High rates of anxiety and depression occur in individuals with temporal lobe epilepsy (TLE), the most common form of focal epilepsy in adults. Rats that have experienced early life stress show increased anxiety, decreased seizure thresholds and accelerated epilepsy as adults. We have important leads to mechanisms. The proposed study will better understand the mechanisms connecting early life stress and psychiatric disease to adult TLE, and to test interventions that may counteract these effects.
A Randomised Stepped Wedge Trial Of The Scaling Up Of A Community Based Alcohol Education Program In Rural Sri Lankan Villages And Its Effects On Alcohol Use, And Associated Harms, Depression And Social Capital.
Funder
National Health and Medical Research Council
Funding Amount
$825,364.00
Summary
Alcohol use is major problem in much of rural Asia. In addition to direct effects on health it is major contributor to suicide, domestic violence and poverty. Much of the alcohol consumed is illicit and so consumption is not influenced by regulation or taxation. This is a trial of a community intervention in rural Sri Lanka to reduce alcohol use and alcohol related disorders that uses participatory drama in conjunction with previously trialed educational materials.
Special Research Initiatives - Grant ID: SR0354576
Funder
Australian Research Council
Funding Amount
$30,000.00
Summary
Spatially Integrated Social Science Research in Australia. Rapid change across society has resulted in shifts to the scope of social science research including the emergence of space and place as an important concept. Across research fields the result has been that a range of innovative and unique techniques, methodologies and theories that are space based are now being developed. While research is progressing rapidly, it is undertaken in parallel by researchers who can not always collaborate. ....Spatially Integrated Social Science Research in Australia. Rapid change across society has resulted in shifts to the scope of social science research including the emergence of space and place as an important concept. Across research fields the result has been that a range of innovative and unique techniques, methodologies and theories that are space based are now being developed. While research is progressing rapidly, it is undertaken in parallel by researchers who can not always collaborate. Recognising these advances, this initiative focuses on harnessing Australia's capacity and potential in the use of spatially based methods and theories and brings researchers together in collaboration across a number of fields. Read moreRead less
ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial ....ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial concepts into statistical analysis and modelling, powerful visualisation of information, and the building spatial decision support systems, to provide an improved evidence base and better informed decision-making to address the significant challenges facing Australia's people and its places.Read moreRead less
Emotional Behaviour in England, 1930-1980. My aim is produce a study of emotional behaviour in England. This will be a contribution to the expanding history of gender and of the self. The project will demonstrate the importance, in terms of insights into cultural change, of recovery of previous emotional standards. Additionally it will test the claims that have been made about governmentality in the twentieth century.
Engineering an artificial protein molecular motor. This project aims to use non-motor protein building blocks to construct an artificial protein motor. Nature already uses nanotechnology as the basis for all its machinery, and uses proteins to construct machines. Each protein component in the motor will have a well-understood function; this artificial protein will elucidate how it converts chemical energy to motion. This process is not understood as molecular motors do not obey the same principl ....Engineering an artificial protein molecular motor. This project aims to use non-motor protein building blocks to construct an artificial protein motor. Nature already uses nanotechnology as the basis for all its machinery, and uses proteins to construct machines. Each protein component in the motor will have a well-understood function; this artificial protein will elucidate how it converts chemical energy to motion. This process is not understood as molecular motors do not obey the same principles as macroscopic machines. Comparing the artificial motor with biological motors will provide insight into the workings of natural motors. This project should lead to molecular motors for nanobiotechnology.Read moreRead less
Special Research Initiatives - Grant ID: SR120300015
Funder
Australian Research Council
Funding Amount
$16,000,000.00
Summary
The Science of Learning Research Centre. In this innovative new Centre, researchers in education, neuroscience and cognitive psychology will work together with teachers to understand the learning process. This collaboration will establish new criteria to assess the impact of different types of learning and strategies to inform teaching practices of benefit to all Australians.