Role Of Tenascin-C And TLR-4 In Carotid Atherosclerosis Related Stroke
Funder
National Health and Medical Research Council
Funding Amount
$308,071.00
Summary
It is estimated that approximately 10,000 Australians per year suffer from strokes related to neck artery disease. Warning signs often go undiagnosed and unreported. Currently there are no blood tests available for early simple diagnosis and few specific drugs available to reduce the number of strokes. Based on preliminary studies we will investigate the role of a novel protein and its related pathway in stroke. We will also study the value of these proteins as a blood test for this problem.
The Role Of Tenascin-C In Bone And Joint Pathology
Funder
National Health and Medical Research Council
Funding Amount
$215,773.00
Summary
Many diseases of bones (e.g.osteoporosis) and joints (e.g. arthritis) result from the abnormal function of cells in these tissues. Factors regulating cell function are, therefore, important in maintaining a healthy skeleton, as well as in the skeleton's response to disease. Tenascin-C is a protein produced by bone and joint cells. The role of tenascin-C in the function of bone-forming cells (osteoblasts) and bone-resorbing cells (osteoclasts) will be investigated. We will investigate whether ten ....Many diseases of bones (e.g.osteoporosis) and joints (e.g. arthritis) result from the abnormal function of cells in these tissues. Factors regulating cell function are, therefore, important in maintaining a healthy skeleton, as well as in the skeleton's response to disease. Tenascin-C is a protein produced by bone and joint cells. The role of tenascin-C in the function of bone-forming cells (osteoblasts) and bone-resorbing cells (osteoclasts) will be investigated. We will investigate whether tenascin-C is required for the bone loss that occurs in female mice when oestrogen is not present. We will also determine the role played by tenascin-C in development and recovery from arthritis. This study will contribute to the understanding of how bone and joint cells function in health and disease.Read moreRead less