Creative Economy:Investigating South Australia's Creative Industries. This project aims at providing a rich and informative data set and analyses of South Australia's Creative Industries to enable a better understanding of the value networks operating in, across and beyond sectors and enable the State's creative industries to be benchmarked against their national and global counterparts. It will carry out a comprehensive, finely granulated, bottom up data gathering exercise and associated analy ....Creative Economy:Investigating South Australia's Creative Industries. This project aims at providing a rich and informative data set and analyses of South Australia's Creative Industries to enable a better understanding of the value networks operating in, across and beyond sectors and enable the State's creative industries to be benchmarked against their national and global counterparts. It will carry out a comprehensive, finely granulated, bottom up data gathering exercise and associated analyses needed at the State level to identify gaps in existing information for addressing policy settings and development. This will extend to a cross-sectoral cluster analysis and support a sustainable industry policy within the changing media environment.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100200
Funder
Australian Research Council
Funding Amount
$418,398.00
Summary
Next generation causal inference methods for biological data. This project aims to develop next generation causal inference methods for analysing biological data especially the single cell sequencing data and their applications in cell biology. Although Artificial Intelligence and Statistical Machine Learning have been applied successfully in many fields, including biological research, there is still a serious lack of methods for interpreting and reasoning about the mechanism of biological syste ....Next generation causal inference methods for biological data. This project aims to develop next generation causal inference methods for analysing biological data especially the single cell sequencing data and their applications in cell biology. Although Artificial Intelligence and Statistical Machine Learning have been applied successfully in many fields, including biological research, there is still a serious lack of methods for interpreting and reasoning about the mechanism of biological systems, the ultimate goal of research in many areas. Efficient data-driven causality discovery approaches developed by the project will be a timely and significant contribution to the knowledge of biology and statistics as well as the battle against health threats.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100040
Funder
Australian Research Council
Funding Amount
$1,375,000.00
Summary
An advanced electron microscope facility for nanomaterials, functional materials and minerals. An advanced electron microscope facility for nanomaterials, functional materials and minerals: Recent advances in electron microscopy provide instruments that can resolve at the atomic level and image both morphologically and chemically at these resolutions. These modern instruments are also less complex to operate therefore allowing many more researchers to access them directly. The High Resolution Sc ....An advanced electron microscope facility for nanomaterials, functional materials and minerals. An advanced electron microscope facility for nanomaterials, functional materials and minerals: Recent advances in electron microscopy provide instruments that can resolve at the atomic level and image both morphologically and chemically at these resolutions. These modern instruments are also less complex to operate therefore allowing many more researchers to access them directly. The High Resolution Scanning Transmission Electron Microscope will allow a complete, nano-scale characterisation of natural and synthetic materials in a broad range of scientific, engineering and industrial applications. The Field Emission Scanning Electron Microscope will provide nano-science users with a tool that can image many of the processes in the formation of these nanostructures and particles.Read moreRead less
Special Research Initiatives - Grant ID: SR120200004
Funder
Australian Research Council
Funding Amount
$30,000,000.00
Summary
Australian Synchrotron Access Program. The Australian Synchrotron epitomises scientific research excellence in Australian and New Zealand. Its impact spans nearly every research sector. This proposal brings together over 30 Australian universities working together to ensure that world-class peer-reviewed science continues to be performed at the Australian Synchrotron.
Quantitative Metagenomics. This project aims to revolutionize our view of the microbial world once more by transforming microbiome studies from relative counts of organisms to actual numbers of microbes. This project expects to impact all the microbiome studies that are being performed worldwide by unveiling the actual numbers of microbes. Expected outcomes of this project include new techniques to enumerate the number of bacteria in different environments and new approaches to measure gene expr ....Quantitative Metagenomics. This project aims to revolutionize our view of the microbial world once more by transforming microbiome studies from relative counts of organisms to actual numbers of microbes. This project expects to impact all the microbiome studies that are being performed worldwide by unveiling the actual numbers of microbes. Expected outcomes of this project include new techniques to enumerate the number of bacteria in different environments and new approaches to measure gene expression within individual bacteria in any environment that will be demonstrated with complex microbial communities. This should provide significant benefits because microbes affect every aspect of our lives and those effects are driven by how many microbes are present.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100963
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Biofilms and quorum sensing in pneumococcal biology. Bacteria survive in their environmental niches by development of complex multicellular communities (biofilms), not by operating as individuals. Communication between bacteria is critical for biofilm formation, and is linked to their capacity to exchange DNA within and between species (competence). This is achieved by secretion and detection of small chemical signalling molecules (quorum sensing). Two such systems operate in the pneumococcus, a ....Biofilms and quorum sensing in pneumococcal biology. Bacteria survive in their environmental niches by development of complex multicellular communities (biofilms), not by operating as individuals. Communication between bacteria is critical for biofilm formation, and is linked to their capacity to exchange DNA within and between species (competence). This is achieved by secretion and detection of small chemical signalling molecules (quorum sensing). Two such systems operate in the pneumococcus, a model Gram-positive organism. This project aims to elucidate the mechanism whereby these quorum sensing systems interact and collaborate to regulate biofilm formation and competence, phenotypes critical for bacterial survival. This knowledge will enable future development of novel antimicrobials. Read moreRead less
Surface Engineered Biomaterials to Control Inflammation. The overarching aim of this project is to provide a mechanistic understanding of how surface nanotopography affects inflammatory responses. Experimental evidence demonstrates that engineered surface nanotopography in combination with surface chemistry downregulates the expression of proinflammatory cytokines from primary macrophages. The significance of these findings is that it may be possible to engineer the nanotopography of a biomedica ....Surface Engineered Biomaterials to Control Inflammation. The overarching aim of this project is to provide a mechanistic understanding of how surface nanotopography affects inflammatory responses. Experimental evidence demonstrates that engineered surface nanotopography in combination with surface chemistry downregulates the expression of proinflammatory cytokines from primary macrophages. The significance of these findings is that it may be possible to engineer the nanotopography of a biomedical device surface in a manner which leads to a desired and predictable level of inflammation and subsequent foreign body reaction (FBR) medical implants and tissue engineering constructs.Read moreRead less
Shedding light on Neanderthal histories using luminescence chronologies. This project aims to develop unprecedented reconstructions of Neanderthal evolution, cultural and extinction histories at previously undatable or understudied European archaeology sites using a versatile luminescence dating toolkit. It will integrate multiple dating methods, palaeoclimate proxies and palaeoecological data to provide comprehensive knowledge of the timing, context and nature of Neanderthal evolution. Expected ....Shedding light on Neanderthal histories using luminescence chronologies. This project aims to develop unprecedented reconstructions of Neanderthal evolution, cultural and extinction histories at previously undatable or understudied European archaeology sites using a versatile luminescence dating toolkit. It will integrate multiple dating methods, palaeoclimate proxies and palaeoecological data to provide comprehensive knowledge of the timing, context and nature of Neanderthal evolution. Expected outcomes include unravelling past human responses to climate change, elucidating regional occupation patterns, emergence of complex behaviours, and causes of Neanderthal demise; with benefits for refining our own species deep-time evolutionary trajectory and global expansion across different regions, including Australia.Read moreRead less
Pushing the Boundaries of Multi-modal Biospectroscopic Microscopies. In order to understand the fundamentals of life processes, diseases, and their treatments, it is essential to probe fundamental changes in molecular processes in cells, tissues and whole organisms. Much of our understanding of these processes has involved the introduction of chemical probes for biospectroscopy, but these have inherent problems because the probe can often change the biochemistry that is being probed. This projec ....Pushing the Boundaries of Multi-modal Biospectroscopic Microscopies. In order to understand the fundamentals of life processes, diseases, and their treatments, it is essential to probe fundamental changes in molecular processes in cells, tissues and whole organisms. Much of our understanding of these processes has involved the introduction of chemical probes for biospectroscopy, but these have inherent problems because the probe can often change the biochemistry that is being probed. This project will push the boundaries of a variety of micro and nano "probe-free" microscopies to provide fundamental insights into these life processes, which could ultimately lead to improvements in the diagnosis, prevention and treatment of diseases.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100147
Funder
Australian Research Council
Funding Amount
$900,000.00
Summary
Revitalising NMR facilities in South Australia - Stage 2. The determination of molecular structure using Nuclear Magnetic Resonance (NMR) is a fundamental and powerful technique that is utilised by researchers across numerous disciplines. We are proposing to upgrade NMR facilities within South Australia in a carefully staged process so as to provide researchers access to state of the art experiments on modern instrumentation. In this proposal we aim to replace end of life components as well as p ....Revitalising NMR facilities in South Australia - Stage 2. The determination of molecular structure using Nuclear Magnetic Resonance (NMR) is a fundamental and powerful technique that is utilised by researchers across numerous disciplines. We are proposing to upgrade NMR facilities within South Australia in a carefully staged process so as to provide researchers access to state of the art experiments on modern instrumentation. In this proposal we aim to replace end of life components as well as provide increased sensitivity and capability by installing new probes. We aim to minimise duplication and maximise capability by undertaking a coordinated approach to NMR upgrades.Read moreRead less