Improvement of anthracycline chemotherapy by enhancement of apoptotic responses and tumour targeted activation. Improved outcomes for anthracycline anticancer chemotherapy is of clear benefit to the nation. Tumour-localised treatment is expected to lead to improved responses, reduced side-effects and improved quality of life while rational selection of drug combinations is expected to enable treatment of tumours that were previously resistant to anthracyclines. With an aging population in Austra ....Improvement of anthracycline chemotherapy by enhancement of apoptotic responses and tumour targeted activation. Improved outcomes for anthracycline anticancer chemotherapy is of clear benefit to the nation. Tumour-localised treatment is expected to lead to improved responses, reduced side-effects and improved quality of life while rational selection of drug combinations is expected to enable treatment of tumours that were previously resistant to anthracyclines. With an aging population in Australia the incidence of cancer is predicted to rise dramatically - improved treatment outcomes and better use of chemotherapeutics will be of obvious national benefit. The development of new tumour-targeted agents is the subject of joint Intellectual Property between Australia and the USA, offering potential economic benefit. Read moreRead less
Novel pharmacological agents to target stroke-induced brain injury. There is a looming stroke epidemic in Australia. 72% of Australian stroke sufferers are over the age of 65 and whereas in 1997 only 12% of Australians were in that age group, by 2030 that number will have increased to 23%. There is an urgent need for novel therapies. This project will aid the development of a novel anti-stroke therapy.
Testing the adaptive capacity of reef corals to rising sea surface temperatures. Australia's reefs are highly profitable resources. Tourism on the Great Barrier Reef contributes over $6 billion annually to the nation's economy and employs over 65,000 people. This proposal will produce world class research to quantify the extent to which corals can respond to climate change; a question central to managing these important resources. The research will also consolidate Australia's position as the le ....Testing the adaptive capacity of reef corals to rising sea surface temperatures. Australia's reefs are highly profitable resources. Tourism on the Great Barrier Reef contributes over $6 billion annually to the nation's economy and employs over 65,000 people. This proposal will produce world class research to quantify the extent to which corals can respond to climate change; a question central to managing these important resources. The research will also consolidate Australia's position as the leading nation in coral reef studies. Priority Goals addressed include Responding to Climate Change and Sustainable use of Australia Biodiversity.Read moreRead less
Quantifying the effects of western colonisation on Great Barrier Reef molluscan communities. Dead shells provide a record of the pre-colonisation Great Barrier Reef (GBR) ecosystem. Using this record this research will determine what the GBR looked like before James Cook and the first fleet arrived in Australia. This study will also sample living molluscs to quantify the current state of these communities. Together these data will provide environment managers and stakeholders with the first quan ....Quantifying the effects of western colonisation on Great Barrier Reef molluscan communities. Dead shells provide a record of the pre-colonisation Great Barrier Reef (GBR) ecosystem. Using this record this research will determine what the GBR looked like before James Cook and the first fleet arrived in Australia. This study will also sample living molluscs to quantify the current state of these communities. Together these data will provide environment managers and stakeholders with the first quantitative estimates of human impacts on this world heritage ecosystem. This project will address the questions: Do protected areas return to a pre-colonial state or do they represent another non-natural state? What type of management scheme results in communities most similar to the pre-colonial state?Read moreRead less
Enhancing coral reef resilience to climate change. Coral reefs provide enormous economic, cultural and environmental benefits to Australia and its near neighbours. For reefs to remain healthy in the face of climate change and other stresses, they must be managed using best practices. Measuring how reef populations are connected and developing new tools to translate this knowledge into improved management can enhance fisheries, ensure reef health, and protect the livelihoods that reefs sustain. T ....Enhancing coral reef resilience to climate change. Coral reefs provide enormous economic, cultural and environmental benefits to Australia and its near neighbours. For reefs to remain healthy in the face of climate change and other stresses, they must be managed using best practices. Measuring how reef populations are connected and developing new tools to translate this knowledge into improved management can enhance fisheries, ensure reef health, and protect the livelihoods that reefs sustain. This research with partners from Europe, the United States of America, Papua New Guinea and Indonesia places Australia at the forefront of addressing the impacts of climate change and enhances its international reputation as the world leader in coral reef science and management.Read moreRead less