Novel Bioinformatics approaches for genetics and data linkage. The research project will involve creation of novel data and communications formats to fulfil the vital task of integrating the vast heterogeneous biological resources available. We will apply this new infrastructure to a large data linkage project. In parallel, we will undertake methodological research in informatics to design high throughput research methods and tools to analyse and visualise genetic data. These will be applied to ....Novel Bioinformatics approaches for genetics and data linkage. The research project will involve creation of novel data and communications formats to fulfil the vital task of integrating the vast heterogeneous biological resources available. We will apply this new infrastructure to a large data linkage project. In parallel, we will undertake methodological research in informatics to design high throughput research methods and tools to analyse and visualise genetic data. These will be applied to linkage disequilibrium mapping and haplotyping in human, animal and plant diseases. Improving informatics integration and designing novel methods and implementations of algorithms will be beneficial to local and international researchers in a range of fields.Read moreRead less
Mitochondrially targeted anti-cancer drugs modulate the mitochondrial genome. Successful cancer management requires novel therapeutical approaches. This project will test the effect of a new class of compounds that target mitochondria, the powerhouse of the cells, where they suppress expression of mitochondrial genes. By this mechanism, cancers that are resistant to apoptosis induction can be inhibited.
Novel platinum(IV) complexes that are targeted to and trapped by tumours and tumour cells. Platinum complexes continue to be a mainstay in the treatment of solid tumours and their combination with molecularly targeted agents selected for the type of tumour and the mutations identified is expected to lead to continued growth in their use. However, their toxicity remains a major impediment to their use and effectiveness and therefore, this project aims to develop less toxic analogues that are as l ....Novel platinum(IV) complexes that are targeted to and trapped by tumours and tumour cells. Platinum complexes continue to be a mainstay in the treatment of solid tumours and their combination with molecularly targeted agents selected for the type of tumour and the mutations identified is expected to lead to continued growth in their use. However, their toxicity remains a major impediment to their use and effectiveness and therefore, this project aims to develop less toxic analogues that are as least as effective as current drugs. This project will combine recent developments in stabilisation and cellular trapping of platinum(IV) pro-drugs with a range of strategies designed to limit activation of these pro-drugs to the tumour environment.Read moreRead less
The Impact of Enterprise Resource Planning Systems on Australian Organizations. Enterprise Resource Planning (ERP) implementation is one of the most pervasive sources of technological change in contemporary Australian enterprises. ERP systems are computer-based technologies that are designed to increase efficiency and achieve major cost savings across the entire organization. Their implementation has significant implications for the structure, nature and management of organizations. This project ....The Impact of Enterprise Resource Planning Systems on Australian Organizations. Enterprise Resource Planning (ERP) implementation is one of the most pervasive sources of technological change in contemporary Australian enterprises. ERP systems are computer-based technologies that are designed to increase efficiency and achieve major cost savings across the entire organization. Their implementation has significant implications for the structure, nature and management of organizations. This project's innovative application of an organizational change model to eight detailed case studies across a range of organizational types will generate important new insights into the effects of ERP implementations at Australian organizations and help explain why some implementations are more successful than others.Read moreRead less
Managing age in organisational context: a comparative study of the meaning of age among managers. Australians are currently being encouraged to work longer to maximise their contribution to the economy but they often report there are organisational barriers to doing so. This study offers a new approach to understanding age focusing on managers and offers a framework of effective strategies for employers in managing age.
Low carbon transition in the Australian energy sector. This project aims to investigate the Australian energy sector’s responses to low emission pressures, comparing the role of different actors in the transition, and developing a model explaining the political dynamics of the transition. The project will provide policy-makers and industry leaders with the means to develop innovative policies and support best practice to assist Australia’s transition towards energy competitiveness. This project ....Low carbon transition in the Australian energy sector. This project aims to investigate the Australian energy sector’s responses to low emission pressures, comparing the role of different actors in the transition, and developing a model explaining the political dynamics of the transition. The project will provide policy-makers and industry leaders with the means to develop innovative policies and support best practice to assist Australia’s transition towards energy competitiveness. This project expects to provide significant benefits such as new insights into the potential for a low emissions future for Australia.Read moreRead less
Ethics as Practice - A Study of Organisational Learning and Management Power in Australian Society. The research will ask how:
- Organizations learn their ethics in and through management practice?
- Learning relates to community expectations of organizations?
- Organizational ethical practices relate to the public image that organizations portray?
Using ethnographic methods we will research how concrete organizational practice is informed by ethics and foregrounded through organizational l ....Ethics as Practice - A Study of Organisational Learning and Management Power in Australian Society. The research will ask how:
- Organizations learn their ethics in and through management practice?
- Learning relates to community expectations of organizations?
- Organizational ethical practices relate to the public image that organizations portray?
Using ethnographic methods we will research how concrete organizational practice is informed by ethics and foregrounded through organizational learning. Managerial practice will be compared with broader concerns embedded in community expectations. Comparisons will be drawn between espoused portrayals of public images by organizations with the power practices that inform everyday managerial behaviour. We will produce a model for organizational learning and ethical management practice.
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Risk and Change In Institutional Fields: The Case Of Industrial Chemicals. This project aims to explore how to manage risk through sustainable organisational strategies and institutional transformations. Chemical risks arise as by-products of economic and technological progress and can cause untold harm to human health and the environment. Using a discursive approach to compare how organisations in Australia and Canada manage chemical risks, this project aims to show how organisations can act as ....Risk and Change In Institutional Fields: The Case Of Industrial Chemicals. This project aims to explore how to manage risk through sustainable organisational strategies and institutional transformations. Chemical risks arise as by-products of economic and technological progress and can cause untold harm to human health and the environment. Using a discursive approach to compare how organisations in Australia and Canada manage chemical risks, this project aims to show how organisations can act as institutional entrepreneurs and introduce sustainable field-level solutions to risk, instead of relying on government regulation to deal with dangerous chemicals. The intended outcomes include the development of a model that identifies the challenges associated with three different risk scenarios – managing established risks, managing emerging risks and eliminating risks – as well as identifying and evaluating strategies to address these challenges.Read moreRead less
An organizational perspective on risk assessment: comparing chemicals management in Australia and Canada. The project compares the managerial and organisational implications of chemical risk assessment in Australia and Canada. It will identify how governments can effectively manage the relationships among different stakeholder organisations involved in risk assessment; and explore how different cultural contexts influence risk assessment.
Customising work through manager-employee exchange. This project will explore how managers and employees customise the terms and conditions of standardised employment arrangements. The results will inform legislation such as right to request provisions and organisational strategies such as manager training which support effective, mutually beneficial manager-employee exchanges.