We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Alpha-particles linked to recombinant antibodies targeting tumour cells have potential to effectively treat tumours while minimising normal tissue side effects. We will explore a novel alpha-particle therapy approach to solid tumours, by delivering 225Ac directly into tumour cells, or into cells that support the tumour (microenvironment). This approach will hopefully result in development of a new approach to treatment of cancers that are resistant to conventional therapies.
Melanotransferrin: A “Missing Link” And A Novel Pharmacological Target For Treatment
Funder
National Health and Medical Research Council
Funding Amount
$613,848.00
Summary
Despite >30 years of research, the precise function of the protein, melanotransferrin (MTf), is unknown. However, we have breakthrough evidence that MTf stimulates WNT signalling as a major driver in cancer progression. We will investigate this hypothesis, which will underpin new cancer therapies. Indeed, we designed a new class of drugs that target the WNT pathway via up-regulating the WNT inhibitor, NDRG1. This drug (DpC) inhibits MTf expression to block tumour cell growth and metastasis.
Humanisation And Pre-clinical Validation Of A Therapeutic Anti-cancer Antibody
Funder
National Health and Medical Research Council
Funding Amount
$699,136.00
Summary
This grant will develop a novel antibody against a protease expressed on cancer cells. Preclinical studies, and antibody humanisation, will be performed. This project will also provide vital information on optimal therapeutic approaches with the antibody that can be ultimately taken into human trials.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100006
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
An adaptable and dedicated linear accelerator for medical radiation research. Leading radiation scientists developing innovative methods and devices for treating cancer patients will collaborate in future research using this highly adaptable linear accelerator for medical radiation research. Innovations in tumour targeting, better patient safety, new medical devices and improved cancer outcomes are expected.
ADAM Metalloprotease Inhibition For Treatment Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$770,925.00
Summary
Colorectal cancer (CRC) causes over 4000 deaths/year, typically from developing drug resistance and spreading to other organs (metastasis). These processes involve tumour cells called cancer stem cells (CSCs), which rely on specific cell surface proteins for survival and function. We are developing antibodies against one of these type of proteins, to test in mouse models of CRC. These already show promise in targeting CSCs and inhibiting drug-resistance and metastasis in mice.
Governance of information technology programmes: achieving accountability, control and success. This project aims to improve the effectiveness with which IT-enabled programmes are managed by public and private organisations. The theoretical knowledge and guides for good practice emerging from this study will contribute to increased success in managing and delivering complex and vital programmes across Australia.
Discovery Early Career Researcher Award - Grant ID: DE130100860
Funder
Australian Research Council
Funding Amount
$365,586.00
Summary
Upgrading competitive position through foreign direct investment: understanding the role of managerial intentionality in domestic manufacturing firms. This research investigates the process by which firms from small domestic markets, such as Australia, can catch up with global market leaders through acquiring strategic assets overseas. It aims to reveal the role of the strategic intents of firm decision makers in initiating, strategising and supporting the process of competitive catch-up.
Integrating Economic Valuation and Water Quality Modelling for Improving Management of Coastal Catchments. This project will apply and integrate water quality models and economic assessment techniques to assist policy makers and catchment managers balance competing development pressures and environmental concerns in coastal catchments. The research is fundamental to underpinning the sustainable management of coastal catchments which provide major economic, environmental and community benefits. T ....Integrating Economic Valuation and Water Quality Modelling for Improving Management of Coastal Catchments. This project will apply and integrate water quality models and economic assessment techniques to assist policy makers and catchment managers balance competing development pressures and environmental concerns in coastal catchments. The research is fundamental to underpinning the sustainable management of coastal catchments which provide major economic, environmental and community benefits. The project will provide robust tools to predict water quality impacts under a range of conditions and it will develop techniques for the economic valuation of market and non-market impacts. The project will demonstrate the integration of water quality and economic modelling and how it can influence policy and investment in conservation and remediation.Read moreRead less
Cover crops that decrease phosphorus (P) transport from agricultural soils by increasing the efficiency of P fertiliser application. The aim of this project is to develop cover crop practices for the heavily fertilised potato cropping soils of the Robertson district that will minimise erosion and runoff of water potentially rich in phosphorus (P), thereby resulting in significant improvements in the environmental management of this sensitive catchment area. The cover crops will: (i) improve infi ....Cover crops that decrease phosphorus (P) transport from agricultural soils by increasing the efficiency of P fertiliser application. The aim of this project is to develop cover crop practices for the heavily fertilised potato cropping soils of the Robertson district that will minimise erosion and runoff of water potentially rich in phosphorus (P), thereby resulting in significant improvements in the environmental management of this sensitive catchment area. The cover crops will: (i) improve infiltration, decrease erosion, and off-site transport of P; (ii)increase access to accumulated soil P, making it available to a subsequent potato crop, thus decreasing the P loading of the soil; and (iii) have a biofumigation effect that will reduce the use of soil fumigants.
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