We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Alpha-particles linked to recombinant antibodies targeting tumour cells have potential to effectively treat tumours while minimising normal tissue side effects. We will explore a novel alpha-particle therapy approach to solid tumours, by delivering 225Ac directly into tumour cells, or into cells that support the tumour (microenvironment). This approach will hopefully result in development of a new approach to treatment of cancers that are resistant to conventional therapies.
Humanisation And Pre-clinical Validation Of A Therapeutic Anti-cancer Antibody
Funder
National Health and Medical Research Council
Funding Amount
$699,136.00
Summary
This grant will develop a novel antibody against a protease expressed on cancer cells. Preclinical studies, and antibody humanisation, will be performed. This project will also provide vital information on optimal therapeutic approaches with the antibody that can be ultimately taken into human trials.
Managing human resources in an advanced economy from the perspective of emerging Chinese multinationals: the case of NWII in Australia. This project will investigate human resource management practices in the resources sector in Australia and China. The outcomes of this study will provide important theoretical and operational insights into Chinese foreign direct investment for stakeholders such as the Australian government, community, employees and their representatives.
ADAM Metalloprotease Inhibition For Treatment Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$770,925.00
Summary
Colorectal cancer (CRC) causes over 4000 deaths/year, typically from developing drug resistance and spreading to other organs (metastasis). These processes involve tumour cells called cancer stem cells (CSCs), which rely on specific cell surface proteins for survival and function. We are developing antibodies against one of these type of proteins, to test in mouse models of CRC. These already show promise in targeting CSCs and inhibiting drug-resistance and metastasis in mice.
Managing the Volunteer Workforce: Flexible Structures and Strategies to Integrate Volunteers and Paid Workers. Volunteers now play a vital role in many service-oriented organisations. This project proposes an innovative framework to assist organisations to develop flexible and appropriate structures and strategies for the management of volunteer and paid workforces. The approach draws upon Atkinson's (1984) "Flexible Firm" concept. A flexibility model is applied to the relationship between volun ....Managing the Volunteer Workforce: Flexible Structures and Strategies to Integrate Volunteers and Paid Workers. Volunteers now play a vital role in many service-oriented organisations. This project proposes an innovative framework to assist organisations to develop flexible and appropriate structures and strategies for the management of volunteer and paid workforces. The approach draws upon Atkinson's (1984) "Flexible Firm" concept. A flexibility model is applied to the relationship between volunteers and the broader workforce. The project aims (a) to understand, conceptualise and evaluate the roles, functions and structure of volunteer groups within paid workforces; (b) to investigate how positive relationships, training, effective communication and flexibility can enhance the contribution of volunteers in the workforce and (c) to propose mechanisms which can improve the deployment of human capital within larger service-oriented organisations such as the National Museum of Australia and Museum of Victoria.Read moreRead less
A Randomised Trial Of The Augmentation Of Cognitive Behaviour Therapy With Fluoxetine For Anxious School Refusing Youth
Funder
National Health and Medical Research Council
Funding Amount
$539,191.00
Summary
School refusing youth consistently suffer from anxiety and sometimes depression. They become severely emotionally distressed when taken to school and experience social and academic difficulties in the short and long term as well as psychiatric illness in adulthood. Our program investigates whether treatment can be improved by enhancing psychotherapy (cognitive behaviour therapy) which helps over half of anxious school refusing children, with antidepressant-anxiety medication compared to placebo.
Development of psychological capital in emergency service organisations. The project addresses the research priorities ‘Promoting good health and well being for all Australians’ and Safeguarding Australia. The project will identify ways in which the performance and wellbeing of volunteer and paid members of emergency service organisations can be enhanced, potentially diminishing the likelihood of depression, aggression, and other detrimental effects. The findings will also contribute to the qual ....Development of psychological capital in emergency service organisations. The project addresses the research priorities ‘Promoting good health and well being for all Australians’ and Safeguarding Australia. The project will identify ways in which the performance and wellbeing of volunteer and paid members of emergency service organisations can be enhanced, potentially diminishing the likelihood of depression, aggression, and other detrimental effects. The findings will also contribute to the quality of training provided to leaders in emergency services. Theoretically, the project will advance understanding of the mechanisms that underpin the psychological capital construct, placing Australian researchers at the forefront of this important emerging field of inquiry.Read moreRead less
Building capacity for adaptive management in protected areas through improved systems for monitoring and evaluation. The project demonstrates how evaluation can lead to improved management of protected areas. Effectively managed protected areas are essential for biodiversity conservation. Improved management, and hence improved conservation outcomes will flow from enhanced use of monitoring and evaluation data in decision-making. Identifying strengths and weaknesses in management will allow mana ....Building capacity for adaptive management in protected areas through improved systems for monitoring and evaluation. The project demonstrates how evaluation can lead to improved management of protected areas. Effectively managed protected areas are essential for biodiversity conservation. Improved management, and hence improved conservation outcomes will flow from enhanced use of monitoring and evaluation data in decision-making. Identifying strengths and weaknesses in management will allow managers to better allocate resource for more effective conservation outcomes. The project establishes connections with all protected area management agencies in Australia, and will contribute to the development of national policy and practice in protected area evaluation and reporting, thus helping to meet national and international reporting obligations. Read moreRead less