Signalling Networks As Targets For Antibody Therapy In Glioma.
Funder
National Health and Medical Research Council
Funding Amount
$526,683.00
Summary
Antibodies are a major component of the bodies immune system that bind (i.e. stick) to foreign substances such as viruses. Once bound, these antibodies can activate other parts of the immune system, which help destroy the foreign substance. Analogous to the situation above, a number of institutions are testing antibodies that bind to cancer cells, in order to determine if they are able to destroy these cells. It is also possible to generate antibodies that bind to receptors on the surface of can ....Antibodies are a major component of the bodies immune system that bind (i.e. stick) to foreign substances such as viruses. Once bound, these antibodies can activate other parts of the immune system, which help destroy the foreign substance. Analogous to the situation above, a number of institutions are testing antibodies that bind to cancer cells, in order to determine if they are able to destroy these cells. It is also possible to generate antibodies that bind to receptors on the surface of cancer cells and block their function. If you target a receptor critical to the growth or survival of a cancer cell in this way, then swtiching-off this signal may inhibit tumor growth. In this proposal we plan to test a panel antibodies that recognize receptors important to the growth of brain cancer. Two of these antibodies have been generated and the other two will be made as part of this proposal. A key aspect of this proposal will be testing these antibodies in combination to determine how many receptors need to be targeted in order to get complete tumor regressions in animal models. Overall this work will help us identify new therapeutic strategies for the treatment of brain cancer. Finally, we will also analyze the way different receptors interact together in brain cancer cells.Read moreRead less
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Alpha-particles linked to recombinant antibodies targeting tumour cells have potential to effectively treat tumours while minimising normal tissue side effects. We will explore a novel alpha-particle therapy approach to solid tumours, by delivering 225Ac directly into tumour cells, or into cells that support the tumour (microenvironment). This approach will hopefully result in development of a new approach to treatment of cancers that are resistant to conventional therapies.
Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
The Impact of Enterprise Resource Planning Systems on Australian Organizations. Enterprise Resource Planning (ERP) implementation is one of the most pervasive sources of technological change in contemporary Australian enterprises. ERP systems are computer-based technologies that are designed to increase efficiency and achieve major cost savings across the entire organization. Their implementation has significant implications for the structure, nature and management of organizations. This project ....The Impact of Enterprise Resource Planning Systems on Australian Organizations. Enterprise Resource Planning (ERP) implementation is one of the most pervasive sources of technological change in contemporary Australian enterprises. ERP systems are computer-based technologies that are designed to increase efficiency and achieve major cost savings across the entire organization. Their implementation has significant implications for the structure, nature and management of organizations. This project's innovative application of an organizational change model to eight detailed case studies across a range of organizational types will generate important new insights into the effects of ERP implementations at Australian organizations and help explain why some implementations are more successful than others.Read moreRead less
Managing age in organisational context: a comparative study of the meaning of age among managers. Australians are currently being encouraged to work longer to maximise their contribution to the economy but they often report there are organisational barriers to doing so. This study offers a new approach to understanding age focusing on managers and offers a framework of effective strategies for employers in managing age.
Risk and Change In Institutional Fields: The Case Of Industrial Chemicals. This project aims to explore how to manage risk through sustainable organisational strategies and institutional transformations. Chemical risks arise as by-products of economic and technological progress and can cause untold harm to human health and the environment. Using a discursive approach to compare how organisations in Australia and Canada manage chemical risks, this project aims to show how organisations can act as ....Risk and Change In Institutional Fields: The Case Of Industrial Chemicals. This project aims to explore how to manage risk through sustainable organisational strategies and institutional transformations. Chemical risks arise as by-products of economic and technological progress and can cause untold harm to human health and the environment. Using a discursive approach to compare how organisations in Australia and Canada manage chemical risks, this project aims to show how organisations can act as institutional entrepreneurs and introduce sustainable field-level solutions to risk, instead of relying on government regulation to deal with dangerous chemicals. The intended outcomes include the development of a model that identifies the challenges associated with three different risk scenarios – managing established risks, managing emerging risks and eliminating risks – as well as identifying and evaluating strategies to address these challenges.Read moreRead less