Unveiling the epigenome dynamics through the pluripotency continuum. This project aims to utilise stem cells and genomics based technologies, in combination with new computational algorithms to dissect the fundamental molecular events that drive the first steps during development. The project is expected to unveil the basic mechanisms underpinning how genes driving the developmental master plan are controlled in cells that have the capacity to give rise to the whole organism and placenta. The kn ....Unveiling the epigenome dynamics through the pluripotency continuum. This project aims to utilise stem cells and genomics based technologies, in combination with new computational algorithms to dissect the fundamental molecular events that drive the first steps during development. The project is expected to unveil the basic mechanisms underpinning how genes driving the developmental master plan are controlled in cells that have the capacity to give rise to the whole organism and placenta. The knowledge gained from this work will inform and guide future novel approaches, such as in assisted reproductive technologies or regenerative medicine.Read moreRead less
School retention and second chance schooling. This project is concerned with ensuring that students who experience systemic disadvantage are not excluded from the benefits of a formal education. It provides an account and critique of the growth of second chance schooling options catering to such students in both Australia and the UK.
Metabolic control of organ growth and regeneration. One of the fundamental questions in biology is to understand how organ size is regulated at the cellular and organismal level. The Hippo/Yap pathway plays a central role in the regulation of organ size and it is impacted by environmental cues including nutrient status. This research proposal aims to use zebrafish to elucidate the role that the Hippo/Yap pathway plays in reprogramming lipid metabolism to fuel tissue growth in development and reg ....Metabolic control of organ growth and regeneration. One of the fundamental questions in biology is to understand how organ size is regulated at the cellular and organismal level. The Hippo/Yap pathway plays a central role in the regulation of organ size and it is impacted by environmental cues including nutrient status. This research proposal aims to use zebrafish to elucidate the role that the Hippo/Yap pathway plays in reprogramming lipid metabolism to fuel tissue growth in development and regeneration. Ultimately, this work aims to identify metabolic dependencies required for organ growth and regeneration. Expected outcomes include scholarly publications revealing fundamental principles underlying tissue growth, new resources for the research community and training for research students.Read moreRead less
Clarifying transparency: Chinese aid and trade in Latin America. Consensual understandings of transparency and good governance are crucial to the international accommodation of China's economic rise. Through a quantitative survey and qualitative case studies, this project aims to clarify how these terms generate misunderstandings and hinder potential for dialogue between key U.S., Latin American and Chinese actors.
Indigenous solutions to global challenges in the Pacific Islands. The global COVID 19 pandemic represents a unique opportunity to understand the nature and potential of Indigenous sustainable development in Pacific Island communities, where Indigenous practices have been central in responses to closed borders and industry downturns. This project proposes to analyse the efficacy and cultural value of new, pandemic-era Indigenous sustainable development initiatives in sustaining island communities ....Indigenous solutions to global challenges in the Pacific Islands. The global COVID 19 pandemic represents a unique opportunity to understand the nature and potential of Indigenous sustainable development in Pacific Island communities, where Indigenous practices have been central in responses to closed borders and industry downturns. This project proposes to analyse the efficacy and cultural value of new, pandemic-era Indigenous sustainable development initiatives in sustaining island communities. It aims to culminate in a novel geographic theory of Indigenous sustainable development, and to identify new opportunities to support the expansion of Indigenous sustainable development. This should better enable the Pacific Islands region to respond to climate change, pandemics and other global challenges.Read moreRead less
Early start arts programmes to counter radicalisation. This project aims to strengthen interfaith relationships, through youth arts workshops that generate positive images of Muslim and non-Muslim Australian youth belonging together. Anxiety about violent extremism can stigmatise Muslim-Australian youth, but the arts can transform negative effects and amplify feelings of belonging. This project will create early childhood and primary interfaith arts intervention workshops to develop interfaith b ....Early start arts programmes to counter radicalisation. This project aims to strengthen interfaith relationships, through youth arts workshops that generate positive images of Muslim and non-Muslim Australian youth belonging together. Anxiety about violent extremism can stigmatise Muslim-Australian youth, but the arts can transform negative effects and amplify feelings of belonging. This project will create early childhood and primary interfaith arts intervention workshops to develop interfaith bonds at crucial developmental stages. It will also develop a public art campaign featuring images from the workshops about Muslim children belonging to Australian culture. The project has potential economic, social and cultural benefits for Australia.Read moreRead less
What shapes our brain? This project aims to improve our fundamental understanding of the biological mechanisms that drive folding of the cerebral cortex, which occurs during development of the brain. Cortical folding is unique to humans and higher mammals, and is thought to underpin the emergence of intelligence and contribute to higher-order brain functions. This project will enhance knowledge of how the cerebral cortex folds and develop novel tools for analysing brain development. The project ....What shapes our brain? This project aims to improve our fundamental understanding of the biological mechanisms that drive folding of the cerebral cortex, which occurs during development of the brain. Cortical folding is unique to humans and higher mammals, and is thought to underpin the emergence of intelligence and contribute to higher-order brain functions. This project will enhance knowledge of how the cerebral cortex folds and develop novel tools for analysing brain development. The project will provide significant benefits including the generation of fundamental knowledge with implications for future understanding of cortical folding abnormalities in babies born preterm, following fetal growth retardation in utero, or when exposed to maternal alcohol. In the longer term, the project will contribute to improvements to human neurodevelopment and brain health.Read moreRead less
The lipidomics of cell fate. This project aims to dissect the roles of lipids in cell fate. The study of lipids, or lipidomics, is an emerging and exciting area of biological science. The fundamental roles of lipids in development remain vastly understudied. This project will look at reprogramming of somatic cells into stem cells, their pluripotency and differentiation. This will be complemented with studies in the zebrafish, which permits the direct study of cell fate in vivo. This approach is ....The lipidomics of cell fate. This project aims to dissect the roles of lipids in cell fate. The study of lipids, or lipidomics, is an emerging and exciting area of biological science. The fundamental roles of lipids in development remain vastly understudied. This project will look at reprogramming of somatic cells into stem cells, their pluripotency and differentiation. This will be complemented with studies in the zebrafish, which permits the direct study of cell fate in vivo. This approach is a powerful way to unlock major events involved in development and to unmask the roles of lipids in these fundamental mechanisms.Read moreRead less
Apoptotic signalling in virally infected and normal cells. Viral diseases contribute substantially to mortality and morbidity, in Australia and internationally. Emerging viral diseases, including H5N1 avian influenza, have the potential to severely impact on human health and the global economy. Concerns also exist that viruses may be used as bioweapons. This project seeks to define the mechanisms by which cell death occurs and is regulated in healthy cells, and how this is altered in virally inf ....Apoptotic signalling in virally infected and normal cells. Viral diseases contribute substantially to mortality and morbidity, in Australia and internationally. Emerging viral diseases, including H5N1 avian influenza, have the potential to severely impact on human health and the global economy. Concerns also exist that viruses may be used as bioweapons. This project seeks to define the mechanisms by which cell death occurs and is regulated in healthy cells, and how this is altered in virally infected or oncogenically transformed cells. Outcomes of this work may contribute to development of novel anti-cancer and anti-viral therapies, diagnostic reagents and vaccines.Read moreRead less
Gendered engagement and participation in sciences and mathematics. This project aims to identify the reasons for the declining numbers of girls (and boys) studying sciences, technology, engineering and mathematics (STEM) subjects during secondary school. This project will conduct complementary longitudinal studies in Australia, in collaboration with leading international scholars, analysing declining motivations, especially for girls/women, to show how this predicts different STEM career choices ....Gendered engagement and participation in sciences and mathematics. This project aims to identify the reasons for the declining numbers of girls (and boys) studying sciences, technology, engineering and mathematics (STEM) subjects during secondary school. This project will conduct complementary longitudinal studies in Australia, in collaboration with leading international scholars, analysing declining motivations, especially for girls/women, to show how this predicts different STEM career choices and actual occupational outcomes, to yield theoretical developments and inform policy to improve the participation of girls/women (and boys/men) in these fields. Expected outcomes of this project include the provision of comprehensive evidence-informed recommendations to Federal and State government, industry and education stakeholders, which will enable the coordinated development of intervention programs to address these issues.Read moreRead less