Transgenerational Effects Of Male Obesity - Mechanisms And Interventions
Funder
National Health and Medical Research Council
Funding Amount
$829,143.00
Summary
Childhood obesity is associated with obesity in either parent, and obese children tend to become obese adults, forming an intergenerational cycle that promotes obesity. We have identified paternal obesity as an important novel target for intervention to stop the progression of the obesity epidemic. This project investigates supplementation of obese fathers with folate to prevent the adverse impact of paternal obesity on subsequent generations.
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Novel nanostructured high energy cathode material. Recently, the demand for rechargeable batteries has exploded due to the enormous increase in the variety and number of miniaturized devices. It is expected that this demand for high capacity rechargeable batteries as energy sources will become even greater in the future. This program is focused to develop novel high performance cathode materials for lithium rechargeable batteries. The outcomes of the project will be of great benefit to develop ....Novel nanostructured high energy cathode material. Recently, the demand for rechargeable batteries has exploded due to the enormous increase in the variety and number of miniaturized devices. It is expected that this demand for high capacity rechargeable batteries as energy sources will become even greater in the future. This program is focused to develop novel high performance cathode materials for lithium rechargeable batteries. The outcomes of the project will be of great benefit to develop new class rechargeable batteries that are economical, lightweight, environmentlly benign and high energy.Read moreRead less
Integrable Functional and Delay Differential Equations. Major challenges such as predicting epidemics or modelling the dynamics of human movement, rely on our understanding of functional and delay differential equations. This research will provide new methods for prediction and analysis of such models.
Allocating scarce HIV/AIDS antiretroviral drugs in resource-constrained countries: using modelling to develop tools and analyse consequences of ethics and HIV-epidemiology. This project will benefit communities in some of the poorest countries of the world, suffering greatly from the HIV/AIDS epidemic. This research is important and timely for these nations in deciding how to distribute the limited treatment in an ethical manner to address treatment principles of these countries. However, the me ....Allocating scarce HIV/AIDS antiretroviral drugs in resource-constrained countries: using modelling to develop tools and analyse consequences of ethics and HIV-epidemiology. This project will benefit communities in some of the poorest countries of the world, suffering greatly from the HIV/AIDS epidemic. This research is important and timely for these nations in deciding how to distribute the limited treatment in an ethical manner to address treatment principles of these countries. However, the methods developed can also be applied to other diseases in different regions and people, such as Australian aborigines to increase their quality of health. Specifically, an epidemic of Chlamydia is widespread amongst the aboriginal communities of Australia's Northern Territory. Tools developed in this project will be easily adaptable to address control measures for Chlamydia among this population. Read moreRead less
Understanding spatial trends in HIV/AIDS infections in South Africa and Australia. This project will develop quantitative methods that will be used to inform public health officials in understanding past and current HIV/AIDS epidemics as well as planning for the future of these epidemics. It will understand not only the behavioural and demographic characteristics of importance as risk factors for HIV infection in South Africa, the epicentre of the global HIV pandemic, but also the geographical s ....Understanding spatial trends in HIV/AIDS infections in South Africa and Australia. This project will develop quantitative methods that will be used to inform public health officials in understanding past and current HIV/AIDS epidemics as well as planning for the future of these epidemics. It will understand not only the behavioural and demographic characteristics of importance as risk factors for HIV infection in South Africa, the epicentre of the global HIV pandemic, but also the geographical spatial locations in which HIV cases are likely to emerge in the future. This project will also forecast the future geographical trends in Australia's changing HIV epidemic in order to plan for intervention strategies and prepare clinical practice appropriately.Read moreRead less
Evolutionary models and bioinformatic analyses of genetic variation in pathogens. The benefits of this project are better preparedness for the ever-present threat of infectious disease spread and the stimulation of bioinformatic research in Australia. Epidemics such as the Influenza Pandemic of 1918, which killed over 20 million people, highlight the need to understand and track pathogens that can potentially cause such devastation. Along with the development of molecular technologies, it is imp ....Evolutionary models and bioinformatic analyses of genetic variation in pathogens. The benefits of this project are better preparedness for the ever-present threat of infectious disease spread and the stimulation of bioinformatic research in Australia. Epidemics such as the Influenza Pandemic of 1918, which killed over 20 million people, highlight the need to understand and track pathogens that can potentially cause such devastation. Along with the development of molecular technologies, it is important to maintain active creation of analytical methods that appropriately apply to growing databases. These include methods to understand genetic variation in pathogens. This project will help to keep Australia at the forefront of research in theoretical biology.Read moreRead less
Advanced Nanostructured Ceramic Composites for Ultracapacitors. The global climate changes and the related disastrous events such as heat flows, bushfires, and flooding will endanger the Australian population and our natural environment. The implementation of effective devices and technologies to reduce our carbon footprint is a priority task. The project addresses the issue by development of new ultracapacitor materials for next generation green energy storage devices through engineering and im ....Advanced Nanostructured Ceramic Composites for Ultracapacitors. The global climate changes and the related disastrous events such as heat flows, bushfires, and flooding will endanger the Australian population and our natural environment. The implementation of effective devices and technologies to reduce our carbon footprint is a priority task. The project addresses the issue by development of new ultracapacitor materials for next generation green energy storage devices through engineering and implementation of advanced nanoceramics and nanocomposites created by innovative nanotechnologies. The project will also contribute to other national research priorities such as materials and frontier technologies, reduction of atmospheric pollution, and decrease in the energy dependence of our country on oil.Read moreRead less
Multivariate approaches to matching spectra for environmental and forensic purposes. Apart from an increased understanding of these commonly-used analytical methods, and their extension to current problems, the outcome of the project will be programs that can be used by the Environmental Protection Agency to give the probability that an oil spill comes from an alleged source. This evidence may be laid before a court, and is more objective than present methods. The identification of illegal drugs ....Multivariate approaches to matching spectra for environmental and forensic purposes. Apart from an increased understanding of these commonly-used analytical methods, and their extension to current problems, the outcome of the project will be programs that can be used by the Environmental Protection Agency to give the probability that an oil spill comes from an alleged source. This evidence may be laid before a court, and is more objective than present methods. The identification of illegal drugs will also be made possible, including information about the country or region of origin, and the place and processes used to refine the drug.Read moreRead less
Sustainable operation of transformers with better understanding of technical and economic constraints. Transformer failure can be devastating to consumers and network service providers, costing from thousands to millions of dollars in transformer replacement and lost productivity. To avoid such catastrophic failures, the goal of this project will be to develop new methods that can maximise transformer usage and minimise cost before failure occurs.