Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
Predicting scour and scour-induced settlement of subsea infrastructure. This project aims to develop improved predictions and understanding of the potential and extent of scour and scour-induced settlement of subsea infrastructure on mobile seabeds. This is expected to enable scour and settlement to be accounted for directly in engineering stability and serviceability design, overturning current practice which ignores both effects on the basis of using scour protection and costly maintenance and ....Predicting scour and scour-induced settlement of subsea infrastructure. This project aims to develop improved predictions and understanding of the potential and extent of scour and scour-induced settlement of subsea infrastructure on mobile seabeds. This is expected to enable scour and settlement to be accounted for directly in engineering stability and serviceability design, overturning current practice which ignores both effects on the basis of using scour protection and costly maintenance and remediation. Development of accurate predictions is expected to be achieved through physical model testing, numerical modelling and analysis of field data. Predictions should improve subsea reliability and lead to omission of scour protection in some situations, increasing international competitiveness of our offshore oil and gas industry.Read moreRead less
Harnessing the power of oceans: anchors for floating energy devices. This project aims to establish a geotechnical design framework for shared anchoring systems subjected to multidirectional cyclic loading for large integrated arrays of floating wind turbines and floating wave energy converters. This is expected to facilitate new, economic foundation solutions, generating radical cost savings to help unlock Australia's renewable ocean energy resources. The project aims to utilise a blend of stat ....Harnessing the power of oceans: anchors for floating energy devices. This project aims to establish a geotechnical design framework for shared anchoring systems subjected to multidirectional cyclic loading for large integrated arrays of floating wind turbines and floating wave energy converters. This is expected to facilitate new, economic foundation solutions, generating radical cost savings to help unlock Australia's renewable ocean energy resources. The project aims to utilise a blend of state-of-the-art centrifuge modelling techniques and numerical modelling, incorporating an energy-based method and yield envelopes. This innovative methodology aims to establish a validated framework for understanding and predicting foundation performance under the complex load histories arising in renewable ocean energy applications.Read moreRead less
Developing innovative concrete composites by upscaling material properties. This project aims to develop an upscaling process to correlate micro-nano properties of engineering materials to their comprehensive physicochemical properties based on systematic mechanical and statistical analysis approaches and nanoindentation technology. The process will enable assessing material mechanical and viscoelastic properties at a microscale level thus will generate a new knowledge in structural engineering ....Developing innovative concrete composites by upscaling material properties. This project aims to develop an upscaling process to correlate micro-nano properties of engineering materials to their comprehensive physicochemical properties based on systematic mechanical and statistical analysis approaches and nanoindentation technology. The process will enable assessing material mechanical and viscoelastic properties at a microscale level thus will generate a new knowledge in structural engineering discipline including health monitoring, assessment of existing structures, historical buildings, and strengthening and repairing materials in structures. The outcomes are a multiscale link model for upscaling material properties and a development of innovative reinforced concrete composites which are cost-effective and efficient.Read moreRead less
Geopolymer concrete for thin-walled structures in marine environment. This project aims to develop ultra-high performance geopolymer concrete thin-walled structures for the critical infrastructure in the marine environment. It is expected that this project will develop novel design rules for ultra-high performance geopolymer concrete thin-walled structures based on experimental testing, numerical modelling, validation, and simulation. This project is expected to increase the durability of coasta ....Geopolymer concrete for thin-walled structures in marine environment. This project aims to develop ultra-high performance geopolymer concrete thin-walled structures for the critical infrastructure in the marine environment. It is expected that this project will develop novel design rules for ultra-high performance geopolymer concrete thin-walled structures based on experimental testing, numerical modelling, validation, and simulation. This project is expected to increase the durability of coastal infrastructures and significantly reduce the loss of their capacities due to corrosion-induced damage. The development of ultra-high performance geopolymer concrete thin-walled structures is a significant engineering discovery, which is in line with the Australian government 2030 vision for sustainable development.Read moreRead less
Local scour below offshore pipelines on calcareous sediments. This project will improve predictions of erosion around subsea structures in calcareous sediment, allowing potential pipeline self-burial. This will reduce the considerable costs currently spent on pipeline stabilisation and increase the viability of Australia's offshore resources and the competitiveness of the Australian oil and gas industry.
Trustworthy positioning for intelligent transport systems. This project aims to develop a holistic approach for reliable positioning for Intelligent Transport Systems (ITS). This project will address the challenges of integrity monitoring in ITS when using satellite-based technology, its integration with other sensors, and when supported by the proposed Australia National Positioning Infrastructure. It will consider Australian geography, large area, and sparse population, and emphasise rural tra ....Trustworthy positioning for intelligent transport systems. This project aims to develop a holistic approach for reliable positioning for Intelligent Transport Systems (ITS). This project will address the challenges of integrity monitoring in ITS when using satellite-based technology, its integration with other sensors, and when supported by the proposed Australia National Positioning Infrastructure. It will consider Australian geography, large area, and sparse population, and emphasise rural transport. Expected primary outputs include algorithms, a detailed analysis of required systems and recommendations that will help prepare Australia for the importation of self-driving vehicles.Read moreRead less
Containment and Reduction of Rework in Transport Mega Projects. Mega transport projects (>$1 billion) are poorly managed during their construction with significant cost and schedule overruns and benefit shortfalls regularly being experienced. Having to perform rework has been identified as a major factor that contributes to these unintended consequences. As there has been limited research that has empirically examined rework causation, an inability to develop effective rework containment and red ....Containment and Reduction of Rework in Transport Mega Projects. Mega transport projects (>$1 billion) are poorly managed during their construction with significant cost and schedule overruns and benefit shortfalls regularly being experienced. Having to perform rework has been identified as a major factor that contributes to these unintended consequences. As there has been limited research that has empirically examined rework causation, an inability to develop effective rework containment and reduction strategies prevails. This research aims to develop a theoretical model that can be used to develop robust containment and reduction strategies to mitigate the adverse economic, productivity and safety consequences that materialize from performing rework during the construction of mega transport projects.Read moreRead less
A novel precision-engineered microfluidic chip for wear particle research. This project aims to develop 1- novel protocols to generate clinically-relevant wear particles from spinal implants in-vitro and 2- a technological framework for the fabrication of a novel microfluidic 3D spinal implant-on-a-chip with tailored mechanical, material and biological properties. This will provide a cost-effective tool, currently unavailable, that allows investigation into the impact of wear particles on health ....A novel precision-engineered microfluidic chip for wear particle research. This project aims to develop 1- novel protocols to generate clinically-relevant wear particles from spinal implants in-vitro and 2- a technological framework for the fabrication of a novel microfluidic 3D spinal implant-on-a-chip with tailored mechanical, material and biological properties. This will provide a cost-effective tool, currently unavailable, that allows investigation into the impact of wear particles on healthy spinal disc cells. We expect our technological framework to become an invaluable tool for biomedical engineers, biologists, and bio-engineers to work together and generate clinically relevant in-vitro data that supports optimisation for spinal implant design, fabrication, and safety. Read moreRead less
Atomistic mechanisms of the mechanical behaviour of nanostructured silicon carbide films. Advanced silicon carbide (SiC) ceramics are leading candidates for applications in high-power, high-speed machining and high-temperature structural components. Superhardness and high ductility (or high fracture toughness), which have been realized in some nanostructured (ns) SiC films and nanowires, respectively, are desirable properties for many applications. This project aims to understand the mechanisms ....Atomistic mechanisms of the mechanical behaviour of nanostructured silicon carbide films. Advanced silicon carbide (SiC) ceramics are leading candidates for applications in high-power, high-speed machining and high-temperature structural components. Superhardness and high ductility (or high fracture toughness), which have been realized in some nanostructured (ns) SiC films and nanowires, respectively, are desirable properties for many applications. This project aims to understand the mechanisms behind the exceptional properties in ns SiC and to explore the possibility of realizing the two properties in the same ns SiC. The results obtained from this research will be very important for guiding the structural design of SiC with exceptional mechanical properties which will have a wide range of structural applications.Read moreRead less