Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100053
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
State-of-the-Art Facility for Non-destructive Testing of Concrete Infrastructure (N-DETECT). State-of-the-art facility for non-destructive testing of concrete infrastructure: There are many recent examples around the world where ageing concrete infrastructure has led to catastrophic failures with loss of life and severe damage to infrastructure. Non destructive testing (NDT) gives a reliable method to provide an accurate assessment of the condition of a structure. However NDT requires an underst ....State-of-the-Art Facility for Non-destructive Testing of Concrete Infrastructure (N-DETECT). State-of-the-art facility for non-destructive testing of concrete infrastructure: There are many recent examples around the world where ageing concrete infrastructure has led to catastrophic failures with loss of life and severe damage to infrastructure. Non destructive testing (NDT) gives a reliable method to provide an accurate assessment of the condition of a structure. However NDT requires an understanding of the various methods available, and their capabilities and limitations, through systematic research projects. Very little research has been done in Australia and overseas in this area due to lack of facilities. This state-of-the-art testing equipment will provide Australian institutions with a cutting edge facility with portable equipment for NDT related research.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100130
Funder
Australian Research Council
Funding Amount
$320,000.00
Summary
An earthquake shaking table to investigate soil-structure interactions. An earthquake shaking table to investigate soil-structure interactions: This project aims to develop Australia's most advanced earthquake shaking table. Earthquakes are a problem of great significance to Australia. Infrastructure in civil, transport, mining and energy sectors may be at an unacceptable risk of damage under earthquake loading as current design practices do not account for the interaction between infrastructure ....An earthquake shaking table to investigate soil-structure interactions. An earthquake shaking table to investigate soil-structure interactions: This project aims to develop Australia's most advanced earthquake shaking table. Earthquakes are a problem of great significance to Australia. Infrastructure in civil, transport, mining and energy sectors may be at an unacceptable risk of damage under earthquake loading as current design practices do not account for the interaction between infrastructure and the ground under such loading. The shaking table will simulate earthquakes and enable controlled testing of three-tonne models of foundation and soil-structure interaction systems typical of Australia's infrastructure. The discoveries made are expected to be integral to the modernisation of Australia's seismic design standards so that earthquake-induced damage and risk exposure can be minimised.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100058
Funder
Australian Research Council
Funding Amount
$560,000.00
Summary
Three dimensionally compressed and monitored Hopkinson bar . 3D compressed and monitored Hopkinson bar: The 3D compressed and monitored Hopkinson bar allows determination of the dynamic mechanical properties and fracturing behaviour of materials under such confinement. Understanding material behaviour under dynamic loading is essential in dealing with many engineering problems as excavation, fragmentation, earthquake, blasting, and structure design. In geotechnical and structure projects, materi ....Three dimensionally compressed and monitored Hopkinson bar . 3D compressed and monitored Hopkinson bar: The 3D compressed and monitored Hopkinson bar allows determination of the dynamic mechanical properties and fracturing behaviour of materials under such confinement. Understanding material behaviour under dynamic loading is essential in dealing with many engineering problems as excavation, fragmentation, earthquake, blasting, and structure design. In geotechnical and structure projects, materials are often subjected to existing confining stresses. The full-field optical techniques, with an ultra-high speed and resolution camera in the system, aims to assist the quantitative measurement of deformation fields including small strain induced in brittle material's failure and identification of constitutive parameters.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989675
Funder
Australian Research Council
Funding Amount
$180,000.00
Summary
Interface-specific facility for quantifying adsorption and structures at particulate interfaces. The facility will be used by the collaborating universities to investigate adsorption and interface properties with great precision, and to develop new and improved technologies for coal and mineral processing, saline water utilisation, water desalination, energy production and environment protection. In particular, the project will investigate innovative ways of using ion-interface interactions in ....Interface-specific facility for quantifying adsorption and structures at particulate interfaces. The facility will be used by the collaborating universities to investigate adsorption and interface properties with great precision, and to develop new and improved technologies for coal and mineral processing, saline water utilisation, water desalination, energy production and environment protection. In particular, the project will investigate innovative ways of using ion-interface interactions in saline water for cleaning coal and recovering value minerals by flotation, and for improving dissolved air flotation used in water treatment and desalination to produce drinking water. The project will further investigate novel ways of capturing CO2, storing natural gases and hydrogen, and tailoring nutrient nano-crystals for foliar delivery.Read moreRead less
Methane and nitrous oxide emissions from sewers – understanding, modelling and mitigation. The research and industry partners will collaborate on this project to quantify, understand and mitigate emissions of methane and nitrous oxide in sewer networks. Both methane and nitrous oxide are potent greenhouse gases, and their emissions need to be accounted for and mitigated for the water industry to achieve greenhouse neutral water services.
Investigation of novel magneto-optic materials exhibiting high Faraday figure of merit. Magneto-optical materials have a wide range of potential applications in consumer products, telecommunications and defence. Nanotechnologies based on these materials offer an even broader range of emerging applications. Understanding and participating in the development of magneto-optic technologies will therefore be critical to maintaining Australia's knowledge base and expertise in future technological adv ....Investigation of novel magneto-optic materials exhibiting high Faraday figure of merit. Magneto-optical materials have a wide range of potential applications in consumer products, telecommunications and defence. Nanotechnologies based on these materials offer an even broader range of emerging applications. Understanding and participating in the development of magneto-optic technologies will therefore be critical to maintaining Australia's knowledge base and expertise in future technological advances. Given the early stages of development of these technologies, Australia's expertise in material science and the patent rights held by Australian companies in this area, Australia has the opportunity to make major contributions to this field, and the potential to capitalise on the application of these technologies in niche markets.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100101
Funder
Australian Research Council
Funding Amount
$744,697.00
Summary
New generation facility for impact testing. This project aims to develop a new generation, national-impact testing facility to study the impact response of civil and mechanical structures and components. This project expects to seek simultaneous, realistic impact scenarios with very high velocities, which were previously impossible. This will enhance the capability for innovative research on real-time behaviour of components/systems under high amplitude impacts to augment their protection throug ....New generation facility for impact testing. This project aims to develop a new generation, national-impact testing facility to study the impact response of civil and mechanical structures and components. This project expects to seek simultaneous, realistic impact scenarios with very high velocities, which were previously impossible. This will enhance the capability for innovative research on real-time behaviour of components/systems under high amplitude impacts to augment their protection through advanced materials. This project is essential for research on rational design philosophies and effective retrofitting of high-risk buildings, infrastructure and armoured vehicles. Benefits include the saving of lives and property through new knowledge from credible impact testing.Read moreRead less
Development of advanced deterioration model for the design of stabilised pavement bases. The Australian road network is a lifeline infrastructure that underpins the nation's living standards and economy. Much of these roads have deteriorated and require rehabilitation to get a new lease of life. This project intends to develop advanced methods to extend the lives of these pavements using in-situ recycling of old pavement materials.