Hydrostatic Pressure Distributions In Peri-pharyngeal Tissues : Impact On Upper Airway Patency
Funder
National Health and Medical Research Council
Funding Amount
$508,935.00
Summary
The obstructive sleep apnoea hypopnoea syndrome (OSAHS) refers to a condition in which throat blockage occurs during sleep leading to breathing difficulties, including cessation of breathing for short periods of time. OSAHS affects both men and women but is amongst the commonest of chronic disorders of adult males, occurring in ~4% of men over the age of 45 years. In the proposed studies we will develop a computer model of the function of the throat during breathing. A particular focus of our mo ....The obstructive sleep apnoea hypopnoea syndrome (OSAHS) refers to a condition in which throat blockage occurs during sleep leading to breathing difficulties, including cessation of breathing for short periods of time. OSAHS affects both men and women but is amongst the commonest of chronic disorders of adult males, occurring in ~4% of men over the age of 45 years. In the proposed studies we will develop a computer model of the function of the throat during breathing. A particular focus of our model will be the influence of the properties of the tissue that form the walls of the throat. Our goal is to construct a computer model that will be useful in identifying specific features of throat function that make people susceptble to the development of OSAHS. In this manner we hope to provide a tool that can be used to develop new approaches to the treatment and prevention of OSAHS.Read moreRead less
Transgenerational Effects Of Male Obesity - Mechanisms And Interventions
Funder
National Health and Medical Research Council
Funding Amount
$829,143.00
Summary
Childhood obesity is associated with obesity in either parent, and obese children tend to become obese adults, forming an intergenerational cycle that promotes obesity. We have identified paternal obesity as an important novel target for intervention to stop the progression of the obesity epidemic. This project investigates supplementation of obese fathers with folate to prevent the adverse impact of paternal obesity on subsequent generations.
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Development of mock circulatory system for complex haemodynamic modelling. This project aims to develop a unique mock experimental system to study blood flow dynamics in anatomically realistic coronary artery phantoms. The field of cardiology involves complex fluid dynamic problems, which require the expertise of the fluid dynamics engineer to understand the hemodynamics. Significant innovation in manufacturing and experimental measurement methodologies will be required to develop accurate model ....Development of mock circulatory system for complex haemodynamic modelling. This project aims to develop a unique mock experimental system to study blood flow dynamics in anatomically realistic coronary artery phantoms. The field of cardiology involves complex fluid dynamic problems, which require the expertise of the fluid dynamics engineer to understand the hemodynamics. Significant innovation in manufacturing and experimental measurement methodologies will be required to develop accurate models, which will be designed to allow the partner organisation to undertake further hemodynamic research.Read moreRead less
Deadly Commute - Targeting The Trafficking Mechanisms That Licence Inflammatory Cell Death
Funder
National Health and Medical Research Council
Funding Amount
$774,544.00
Summary
MLKL is a protein naturally found inside cells. MLKL is activated by inflammation. Once activated, MLKL relocates to the outer periphery of cells and kills them. Gut cells are especially vulnerable to death-by-MLKL and this problem causes Inflammatory Bowel Disease. Using cutting edge microscopy, we have discovered how MLKL moves to the periphery of cells prior to killing them. We will test if blocking this movement of MLKL to the cell periphery stops gut death and Inflammatory Bowel Disease.
Discovery Early Career Researcher Award - Grant ID: DE180101098
Funder
Australian Research Council
Funding Amount
$374,200.00
Summary
New mathematical theory for fluid motion on surfaces with holes. This project aims to develop new explicit mathematical results to enhance the understanding of potential theory – a fundamental area of mathematics - on surfaces with complicating geometrical properties. There are very few such fundamental results on complicated curved surfaces, such as those with holes. This project should provide a toolbox for solving many different mathematical problems on curved surfaces. The new results should ....New mathematical theory for fluid motion on surfaces with holes. This project aims to develop new explicit mathematical results to enhance the understanding of potential theory – a fundamental area of mathematics - on surfaces with complicating geometrical properties. There are very few such fundamental results on complicated curved surfaces, such as those with holes. This project should provide a toolbox for solving many different mathematical problems on curved surfaces. The new results should also have application to the analysis of fluid flows over porous media and practical engineering structures.Read moreRead less
Force Interactions in Packed and Fluidised Beds at Micro-Scale Operation. Industrial processing in the 20th century was about increasing size to gain benefit from economies of scale. This century, the focus is on micro devices like lab-on-a-chip and high speed computer processors that deliver their product directly to the consumer. There are significant obstacles facing this new technology. Mixing is reduced due to laminar flow, and a large amount of energy is needed to move the fluid through su ....Force Interactions in Packed and Fluidised Beds at Micro-Scale Operation. Industrial processing in the 20th century was about increasing size to gain benefit from economies of scale. This century, the focus is on micro devices like lab-on-a-chip and high speed computer processors that deliver their product directly to the consumer. There are significant obstacles facing this new technology. Mixing is reduced due to laminar flow, and a large amount of energy is needed to move the fluid through such small devices. Particles are often added to improve mixing and heat transfer, but their presence adds to the energy requirements. This study will help us overcome these challenges. Read moreRead less
Particle scale modelling of dense medium cyclones in coal preparation. Australia is the world's biggest coal exporter, and black coal is Australia's largest export, worth around $A13.5 billion annually. Dense medium cyclones process the vast majority of tonnes fed to Australian coal preparation plants, and hence play a critical economic role in coal production. This project aims at providing substantial design and operational improvements through the application of a novel combined continuum and ....Particle scale modelling of dense medium cyclones in coal preparation. Australia is the world's biggest coal exporter, and black coal is Australia's largest export, worth around $A13.5 billion annually. Dense medium cyclones process the vast majority of tonnes fed to Australian coal preparation plants, and hence play a critical economic role in coal production. This project aims at providing substantial design and operational improvements through the application of a novel combined continuum and discrete modelling method. Specifically, the improvements targeted relate to better process and product control, a decrease in unit energy consumption and improvements in productivity, which, together with the research training offered, will further enhance Australia's leading position in global coal industry.Read moreRead less
Microdynamic modelling and analysis of gas fluidization of particle mixtures. The project aims to develop a comprehensive understanding of the mechanisms governing the particle-fluid flow in gas fluidization of mixtures of particles of different sizes. This will be achieved through detailed analysis of the particle-particle and particle-fluid interactions on the basis of the microdynamic or particle scale results generated by the newly developed discrete simulation technique. The microscopic fin ....Microdynamic modelling and analysis of gas fluidization of particle mixtures. The project aims to develop a comprehensive understanding of the mechanisms governing the particle-fluid flow in gas fluidization of mixtures of particles of different sizes. This will be achieved through detailed analysis of the particle-particle and particle-fluid interactions on the basis of the microdynamic or particle scale results generated by the newly developed discrete simulation technique. The microscopic findings will be implemented in the macroscopic, continuum-based modelling and tested by comparing numerical and experimental results. It will significantly enhance the present capability of modelling particle-fluid flow in gas fluidization which is widely used in mineral/chemical industries.Read moreRead less
Touch and Tension: Molecular Determinants of Human Mechanosensation . Feelings of touch and muscle tension are initiated by mechanosensory neurons found within the peripheral nervous system. Knowledge of human mechanosensory neurons has predominantly relied on rodent studies because of the limited availability of human tissue, which is not ideal. Our team has developed novel technologies for generating human mechanosensory neurons ‘in the dish’. The major aim of this project is to use human stem ....Touch and Tension: Molecular Determinants of Human Mechanosensation . Feelings of touch and muscle tension are initiated by mechanosensory neurons found within the peripheral nervous system. Knowledge of human mechanosensory neurons has predominantly relied on rodent studies because of the limited availability of human tissue, which is not ideal. Our team has developed novel technologies for generating human mechanosensory neurons ‘in the dish’. The major aim of this project is to use human stem cell-derived mechanosensory neurons as a platform to extensively study their molecular and functional properties. The significant benefits are the advancement of knowledge in the human mechanosensory system, which to date has been lacking, and in the long-term progress commercial development of novel drugs.Read moreRead less