We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Deadly Commute - Targeting The Trafficking Mechanisms That Licence Inflammatory Cell Death
Funder
National Health and Medical Research Council
Funding Amount
$774,544.00
Summary
MLKL is a protein naturally found inside cells. MLKL is activated by inflammation. Once activated, MLKL relocates to the outer periphery of cells and kills them. Gut cells are especially vulnerable to death-by-MLKL and this problem causes Inflammatory Bowel Disease. Using cutting edge microscopy, we have discovered how MLKL moves to the periphery of cells prior to killing them. We will test if blocking this movement of MLKL to the cell periphery stops gut death and Inflammatory Bowel Disease.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347797
Funder
Australian Research Council
Funding Amount
$263,000.00
Summary
A Versatile High-resolution X-ray Diffractometer for Materials Research. The aim of this project is to establish a state-of-the-art triple-axis x-ray diffraction facility capable of non-destructively analysing complex semiconductor materials and structures investigated by all Australian semiconductor-growing groups. Growers and device engineers will be able to control growth processes accurately and correlate device performance with structural analysis. Modern triple-axis instruments can also b ....A Versatile High-resolution X-ray Diffractometer for Materials Research. The aim of this project is to establish a state-of-the-art triple-axis x-ray diffraction facility capable of non-destructively analysing complex semiconductor materials and structures investigated by all Australian semiconductor-growing groups. Growers and device engineers will be able to control growth processes accurately and correlate device performance with structural analysis. Modern triple-axis instruments can also be used for high-resolution texture analysis and surface reflectivity measurements on numerous types of materials. Thus chemists, geologists, and materials scientists with interests outside of the semiconductor growth community will gain substantial benefit from this instrument for the investigation of materials of technological and economic importance.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100060
Funder
Australian Research Council
Funding Amount
$370,000.00
Summary
Year-round accessible angle-resolved photoemission spectroscopy facility . Year-round accessible angle-resolved photoemission spectroscopy facility: This project aims to create a year-round readily accessible facility for angle-resolved photoemission spectroscopy combined with in situ scanning tunnelling microscopy, cementing Australia's leadership position in novel electronic materials research. The facility is the first of its kind in Australia, housed at the Australian Synchrotron, and access ....Year-round accessible angle-resolved photoemission spectroscopy facility . Year-round accessible angle-resolved photoemission spectroscopy facility: This project aims to create a year-round readily accessible facility for angle-resolved photoemission spectroscopy combined with in situ scanning tunnelling microscopy, cementing Australia's leadership position in novel electronic materials research. The facility is the first of its kind in Australia, housed at the Australian Synchrotron, and accessible to a broad user base. The facility will be an essential tool for study of new electronic materials such as graphene, two-dimensional semiconductors, topological insulators, and superconductors. This research aims to lead to new thermoelectric, photovoltaic, superconducting, and computing devices, revolutionising the generation, transfer, storage, and use of electrical energy.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775646
Funder
Australian Research Council
Funding Amount
$636,000.00
Summary
Surface and Magnetic structure of crystalline materials. This proposal brings together significant research groups in La Trobe University, Monash University, the University of Western Australia, Newcastle University and Sydney University to establish a unique materials characterisation facility which will enable surface and magnetic structures of technologically significant materials to be determined. It will support developments in the areas of new magnetic phenomenon which is used in magnetic ....Surface and Magnetic structure of crystalline materials. This proposal brings together significant research groups in La Trobe University, Monash University, the University of Western Australia, Newcastle University and Sydney University to establish a unique materials characterisation facility which will enable surface and magnetic structures of technologically significant materials to be determined. It will support developments in the areas of new magnetic phenomenon which is used in magnetic sensing and in the exploration of processes of size reduction for electronic devices. It will enable this new, world leading technology, to be applied to surface structures relevant in the areas of nanotechnology and catalysis.Read moreRead less
ARC Centre of Excellence in Exciton Science. This Centre aims to manipulate the way light energy is absorbed, transported and transformed in advanced molecular materials. The research programme spans high-throughput computational screening, single molecule photochemistry and ultrafast spectroscopy and embraces innovative outreach and commercial translation activities. The Centre plans to capture the knowledge generated as new intellectual property, materials processing know-how, and through the ....ARC Centre of Excellence in Exciton Science. This Centre aims to manipulate the way light energy is absorbed, transported and transformed in advanced molecular materials. The research programme spans high-throughput computational screening, single molecule photochemistry and ultrafast spectroscopy and embraces innovative outreach and commercial translation activities. The Centre plans to capture the knowledge generated as new intellectual property, materials processing know-how, and through the creation of new employment opportunities. The expected outcomes and benefits include new Australian technologies in solar energy conversion, energy-efficient lighting and displays, security labelling and optical sensor platforms for defence.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668065
Funder
Australian Research Council
Funding Amount
$623,000.00
Summary
High resolution images of surfaces. This proposal brings together significant research groups in La Trobe University, Macquarie University, the University of Western Australia and ANSTO to work in areas which will enhance Australia's capability in the area of Magnetic devices and spintronics. It will support developments in the areas of new magnetic phenomenon which is used in magnetic sensing and in the exploration of processes of size reduction for electronic devices. It will enhance the acc ....High resolution images of surfaces. This proposal brings together significant research groups in La Trobe University, Macquarie University, the University of Western Australia and ANSTO to work in areas which will enhance Australia's capability in the area of Magnetic devices and spintronics. It will support developments in the areas of new magnetic phenomenon which is used in magnetic sensing and in the exploration of processes of size reduction for electronic devices. It will enhance the access of undergraduates and postgraduates to the emerging technologies. It will connect Australia to internationally significant research outcomes leading to, for example, new magnetic and electronic devices with a continuing decrease in their size. Read moreRead less
Australian Laureate Fellowships - Grant ID: FL120100038
Funder
Australian Research Council
Funding Amount
$2,645,586.00
Summary
Understanding and controlling the properties of Dirac electronic materials. This project will gain deep insights into a new class of materials that includes graphene, the thinnest possible plane of carbon. New electronic properties will be engineered in Dirac materials to make them valuable for applications in computing, sensors, and solar power generation.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100081
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Combined scanning tunnelling microscope system for materials characterisation and manipulation at nano scale. The proposed facility is unique in Australia and will substantially enhance national research capabilities in nano-materials, nanotechnology and biotechnology. The proposed infrastructure project will bring more than 20 leading Australian research groups from 10 institutions together to create an outstanding platform to underpin close collaborations among members in a broad field. The pr ....Combined scanning tunnelling microscope system for materials characterisation and manipulation at nano scale. The proposed facility is unique in Australia and will substantially enhance national research capabilities in nano-materials, nanotechnology and biotechnology. The proposed infrastructure project will bring more than 20 leading Australian research groups from 10 institutions together to create an outstanding platform to underpin close collaborations among members in a broad field. The proposed facility will provide significant benefits to Australian researchers in drug design and delivery, nano-material design and characterisation at nano scale for advanced materials, and promotion of renewable energy. This represents a great opportunity to make discoveries and breakthroughs in frontier science and technology in Australia.Read moreRead less
Novel Carbon Coatings for Exceptional Performance. Carbon coatings are technologically important and have many applications in automotive and biomedical industries worldwide. An example automotive application is as a coating for high performance fuel injectors. Carbon coatings have significant unrealised potential for applications in hostile environments such as those encountered in high performance engineering components and in the human body. This project will develop new types of carbon coat ....Novel Carbon Coatings for Exceptional Performance. Carbon coatings are technologically important and have many applications in automotive and biomedical industries worldwide. An example automotive application is as a coating for high performance fuel injectors. Carbon coatings have significant unrealised potential for applications in hostile environments such as those encountered in high performance engineering components and in the human body. This project will develop new types of carbon coatings with properties and performance tailored to applications in biomedical engineering, energy conversion, automotive engineering, manufacturing and microelectronics. The result will be a range of new carbon coatings with exceptional properties and cost-effective synthesis methods.Read moreRead less