The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling f ....The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling for a synergistic defence to adapt to the nanoparticle toxicity. The pioneering knowledge is the foundation for technologies targeting the interspecies metabolite cross-talking to overcome the resistance phenomena, ensuring a long-term efficacy of the alternative antimicrobial on the difficult-to-control pathogenic growth.Read moreRead less
A screening human health risk assessment for developing coal seam gas water resources in Queensland, Australia. Due to its rich coal seam deposits, Queensland is projected to become Australia's leading coal seam gas (CSG) producer, contributing significantly to the State's economy and national "clean" energy targets. Over a 30 year period, it is estimated that Queensland's CSG industry could also create by-product water of sufficient volume to beneficially augment the State's future water supply ....A screening human health risk assessment for developing coal seam gas water resources in Queensland, Australia. Due to its rich coal seam deposits, Queensland is projected to become Australia's leading coal seam gas (CSG) producer, contributing significantly to the State's economy and national "clean" energy targets. Over a 30 year period, it is estimated that Queensland's CSG industry could also create by-product water of sufficient volume to beneficially augment the State's future water supply demands. The proposed screening Health Risk Assessment will evaluate the relative risks associated with human exposure to raw and treated CSG by-product water contaminants, informing public debate on this matter, and guide policy development within the complex multi-sector regulatory framework in place for CSG water resource development in Queensland.Read moreRead less
Non-linear modelling for predicting patient presentation rates for mass-gatherings. Mass-gatherings are events where crowds gather. Access to health care at these events is critical, though difficult. Complex interrelationships exist between characteristics of events and presenting patient profiles. To prevent overwhelming local hospital and emergency services it is important to accurately predict patient volume. A predictive model constructed through linear modelling has been widely used. Key f ....Non-linear modelling for predicting patient presentation rates for mass-gatherings. Mass-gatherings are events where crowds gather. Access to health care at these events is critical, though difficult. Complex interrelationships exist between characteristics of events and presenting patient profiles. To prevent overwhelming local hospital and emergency services it is important to accurately predict patient volume. A predictive model constructed through linear modelling has been widely used. Key features affecting patient presentations are non-linear in character and non-linear modelling may provide more accurate patient predictive models. This project provides prospective analysis of data to develop a non-linear predictive model.Read moreRead less
The unfolding story of the 2009 Adelaide heatwave: risk factors for mortality and morbidity. This project will conduct a case control study in Adelaide to explore the risk factors of extra health burden related to the 2009 heatwave. Given the prediction of more extreme heat events, this study will provide important information for policy makers and service providers to assist in the development of more resilient communities to climate change.