Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
The production of pay (in)equity for women: a study of emerging occupations. The aims of this project are to extend understanding of current impediments to pay equity for women, and to elaborate the ways in which pay inequality is re-created in new contexts. The focus is on emerging occupations likely to provide increasing employment opportunities in the near future. This is highly significant research at a time of structural change and when new procedures for addressing pay equity are being dev ....The production of pay (in)equity for women: a study of emerging occupations. The aims of this project are to extend understanding of current impediments to pay equity for women, and to elaborate the ways in which pay inequality is re-created in new contexts. The focus is on emerging occupations likely to provide increasing employment opportunities in the near future. This is highly significant research at a time of structural change and when new procedures for addressing pay equity are being developed in several States following pay equity inquiries. Expected outcomes include enhanced comprehension of the reproduction of pay inequality and evidence to assist the advancement of pay equity through identified mechanisms and strategies.Read moreRead less
From science to policy: quantifying and managing the risk of mosquito borne disease in the context of climate change. It is important to assess and manage the health risks of climate change. This research will create fundamental knowledge and practical skills on the interdisciplinary assessment and management of health risks of climate change, and explore policy ramifications of research outcomes in this study.
Calibration Free Coulometric Sensors Based on Polymeric Thin Layer Films. The world faces enormous environmental and clinical challenges that require accurate data from remote deployable and disposable sensors. Many key parameters important to global warming (carbon dioxide cycle) and clinical diagnostics (blood electrolytes) may be assessed with a polymeric membrane sensing technology, but the measurement principle is not sufficiently robust for remote sensing applications. This research will m ....Calibration Free Coulometric Sensors Based on Polymeric Thin Layer Films. The world faces enormous environmental and clinical challenges that require accurate data from remote deployable and disposable sensors. Many key parameters important to global warming (carbon dioxide cycle) and clinical diagnostics (blood electrolytes) may be assessed with a polymeric membrane sensing technology, but the measurement principle is not sufficiently robust for remote sensing applications. This research will make this possible by adapting calibration free measurement principles (coulometry, or charge counting) to this class of sensors, where a thin layer of sample solution will be depleted by instrumental control. This forms the scientific basis for successfully tackling the measurement challenges of the future.Read moreRead less
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
Farm Women, Networks and ICTs. Considerable national funds have been spent on brining rural Australians online. In the previous year over half of those living in non-metropolitan Australian accessed the internet. However, little is known about how new technologies are being integrated into the daily lives of rural people. This research moves from quantifying technology take-up in rural Australia and describing the possibilities of what new technologies may offer rural people, to analysing and cr ....Farm Women, Networks and ICTs. Considerable national funds have been spent on brining rural Australians online. In the previous year over half of those living in non-metropolitan Australian accessed the internet. However, little is known about how new technologies are being integrated into the daily lives of rural people. This research moves from quantifying technology take-up in rural Australia and describing the possibilities of what new technologies may offer rural people, to analysing and critiquing the extent to which these possibilities are being realised. It will inform policy on rural and regional technology access and use.Read moreRead less
Effective clinical handover communication: improving patient safety, experiences and outcomes. Communication in clinical handover (transfer of responsibility for patient care) plays a causal role in many adverse events. This project will contribute new knowledge for improvements in handover communication which will be shared across hospitals and health departments nationally to improve patient safety and reduce healthcare costs.
ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory ne ....ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory networks and to address how environmental factors impinge on these regulatory networks. The formation of this National Research Network is unique, timely and strategic. It will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
Understanding collaboration between the arts and sciences. This project aims to undertake a detailed examination of how the arts and sciences can work together to address the complex challenges of contemporary life. This will be addressed by undertaking the first cultural history of the experiment. Experimentation is common to the arts and sciences, and thinking about the long history of experimental practices in both fields will help build a bridge between them. This project will examine in de ....Understanding collaboration between the arts and sciences. This project aims to undertake a detailed examination of how the arts and sciences can work together to address the complex challenges of contemporary life. This will be addressed by undertaking the first cultural history of the experiment. Experimentation is common to the arts and sciences, and thinking about the long history of experimental practices in both fields will help build a bridge between them. This project will examine in detail past and present collaboration. An expected outcome is the development of models to support solving of complex contemporary problems. It will also raise awareness about the importance of the arts to knowledge-making practices.Read moreRead less