Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
From science to policy: quantifying and managing the risk of mosquito borne disease in the context of climate change. It is important to assess and manage the health risks of climate change. This research will create fundamental knowledge and practical skills on the interdisciplinary assessment and management of health risks of climate change, and explore policy ramifications of research outcomes in this study.
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
Alcohol and caffeinated energy drinks: exploring patterns of consumption and associated harms. Very little research has been conducted on the functions, contexts, effects and harms associated with combining energy drinks and alcohol, despite the widespread consumption of these beverages by young people. This project will contribute to the knowledge base of this under-researched area and inform harm reduction policy and practice.
Drug enhancement and experimentation. This project aims to research the chemical practices of sexual and gender minorities in Australia and investigate how health agencies have sought to deal with them. Drugs are increasingly and widely used in pharmaceutical markets and lifestyle practices. As pharmaceutical markets expand, the distinction between therapeutic and illicit drugs becomes unclear. Drug consumption can give rise to serious dangers in certain circumstances. This project is expected t ....Drug enhancement and experimentation. This project aims to research the chemical practices of sexual and gender minorities in Australia and investigate how health agencies have sought to deal with them. Drugs are increasingly and widely used in pharmaceutical markets and lifestyle practices. As pharmaceutical markets expand, the distinction between therapeutic and illicit drugs becomes unclear. Drug consumption can give rise to serious dangers in certain circumstances. This project is expected to better understand drugs and medication use and improve public health services.Read moreRead less
Corporate political activity of tobacco, alcohol and gambling companies in Australia. This project investigates how tobacco, alcohol and gambling industries influence the policy process, by stalling or defeating the implementation of effective public health policies in favour of ones which do not affect profit. The study will develop guidelines for industry-government interaction to ensure maximum public benefit.
Effective clinical handover communication: improving patient safety, experiences and outcomes. Communication in clinical handover (transfer of responsibility for patient care) plays a causal role in many adverse events. This project will contribute new knowledge for improvements in handover communication which will be shared across hospitals and health departments nationally to improve patient safety and reduce healthcare costs.
Special Research Initiatives - Grant ID: SR0354622
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the early embryo have major consequences for the development of individuals. The aim of this Network is to harness the resources of leading researchers from the previously distinct disciplines of developmental biology and developmental physiology to better understand developmental regulatory networks and how environmental factors impinge on them. The formation of such a Network ....Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the early embryo have major consequences for the development of individuals. The aim of this Network is to harness the resources of leading researchers from the previously distinct disciplines of developmental biology and developmental physiology to better understand developmental regulatory networks and how environmental factors impinge on them. The formation of such a Network is unique, timely and strategic in that it will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory ne ....ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory networks and to address how environmental factors impinge on these regulatory networks. The formation of this National Research Network is unique, timely and strategic. It will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100140
Funder
Australian Research Council
Funding Amount
$364,163.00
Summary
The policy and practice of designing healthy, equitable higher density. This project aims to investigate higher density housing and the impact of policy guidance, on-ground implementation of building design criteria, and locational characteristics on residents’ wellbeing. Higher density housing is promoted to sustainably accommodate population growth; however, in some Australian cities there is limited design and planning guidance. Could this have implications for the quality, versatility and eq ....The policy and practice of designing healthy, equitable higher density. This project aims to investigate higher density housing and the impact of policy guidance, on-ground implementation of building design criteria, and locational characteristics on residents’ wellbeing. Higher density housing is promoted to sustainably accommodate population growth; however, in some Australian cities there is limited design and planning guidance. Could this have implications for the quality, versatility and equity of the housing provided, and for the health and wellbeing of residents? This project aims to produce new policy-specific empirical evidence around these issues that could inform higher density design guidance in Australia and internationally. Findings have the potential to change public policy to mandate the inclusion of health-enhancing design requirements in future higher density developments.Read moreRead less