Transgenerational Effects Of Male Obesity - Mechanisms And Interventions
Funder
National Health and Medical Research Council
Funding Amount
$829,143.00
Summary
Childhood obesity is associated with obesity in either parent, and obese children tend to become obese adults, forming an intergenerational cycle that promotes obesity. We have identified paternal obesity as an important novel target for intervention to stop the progression of the obesity epidemic. This project investigates supplementation of obese fathers with folate to prevent the adverse impact of paternal obesity on subsequent generations.
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Novel nanostructured high energy cathode material. Recently, the demand for rechargeable batteries has exploded due to the enormous increase in the variety and number of miniaturized devices. It is expected that this demand for high capacity rechargeable batteries as energy sources will become even greater in the future. This program is focused to develop novel high performance cathode materials for lithium rechargeable batteries. The outcomes of the project will be of great benefit to develop ....Novel nanostructured high energy cathode material. Recently, the demand for rechargeable batteries has exploded due to the enormous increase in the variety and number of miniaturized devices. It is expected that this demand for high capacity rechargeable batteries as energy sources will become even greater in the future. This program is focused to develop novel high performance cathode materials for lithium rechargeable batteries. The outcomes of the project will be of great benefit to develop new class rechargeable batteries that are economical, lightweight, environmentlly benign and high energy.Read moreRead less
Advanced Nanostructured Ceramic Composites for Ultracapacitors. The global climate changes and the related disastrous events such as heat flows, bushfires, and flooding will endanger the Australian population and our natural environment. The implementation of effective devices and technologies to reduce our carbon footprint is a priority task. The project addresses the issue by development of new ultracapacitor materials for next generation green energy storage devices through engineering and im ....Advanced Nanostructured Ceramic Composites for Ultracapacitors. The global climate changes and the related disastrous events such as heat flows, bushfires, and flooding will endanger the Australian population and our natural environment. The implementation of effective devices and technologies to reduce our carbon footprint is a priority task. The project addresses the issue by development of new ultracapacitor materials for next generation green energy storage devices through engineering and implementation of advanced nanoceramics and nanocomposites created by innovative nanotechnologies. The project will also contribute to other national research priorities such as materials and frontier technologies, reduction of atmospheric pollution, and decrease in the energy dependence of our country on oil.Read moreRead less
Special Research Initiatives - Grant ID: SR0354535
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Advanced Electromaterials from Nanomaterials and Biomaterials. The proposed initiative brings together relevant sectors of the nanomaterials, biomaterials and electrochemistry research communities. It is envisaged that the collective complementary expertise will give rise to research opportunities and insights into the emerging work of electro-bio-nano. Scientific and technological challenges that exist in this multidiscipline research space include areas as diverse as the development of more ....Advanced Electromaterials from Nanomaterials and Biomaterials. The proposed initiative brings together relevant sectors of the nanomaterials, biomaterials and electrochemistry research communities. It is envisaged that the collective complementary expertise will give rise to research opportunities and insights into the emerging work of electro-bio-nano. Scientific and technological challenges that exist in this multidiscipline research space include areas as diverse as the development of more efficient nerve cell communication implants, understanding and control of biocorrosion/biofouling and the use of biomimicry to produce more efficient catalysts and artificial muscles.Read moreRead less
ARC Centre for Nanostructured Electromaterials. Electromaterials transport electrons or ions and facilitate charge transfer, underpinning most energy capture/storage processes and cell communication. We propose a national Centre to develop nanostructured electromaterials with exceptional properties. The Centre aims to synthesise novel nanomaterials and assemble them into innovative nanoscale devices. We will exploit these materials to enhance performance in energy conversion/storage systems (eg. ....ARC Centre for Nanostructured Electromaterials. Electromaterials transport electrons or ions and facilitate charge transfer, underpinning most energy capture/storage processes and cell communication. We propose a national Centre to develop nanostructured electromaterials with exceptional properties. The Centre aims to synthesise novel nanomaterials and assemble them into innovative nanoscale devices. We will exploit these materials to enhance performance in energy conversion/storage systems (eg. photovoltaics, batteries, including wearable systems), and novel energy transfer in bioapplications (eg. Bionic Ear). These advances, together with the resource of trained personnel, will assist Australian industry to exploit this exciting area.Read moreRead less
Design and Synthesis of Ionic Liquids for Use in Photoelectrochemical Cells Based on Inherently Conducting Polymers. We propose to evaluate the electrochemistry of photoactive polythiophenes recently synthesised by us in a range of ionic liquids. This knowledge will be used to design and synthesise customised ionic liquids with the properties required to enhance the photoelectrochemical efficiency of devices based on substituted polythiophenes. We expect our findings to lead to the development ....Design and Synthesis of Ionic Liquids for Use in Photoelectrochemical Cells Based on Inherently Conducting Polymers. We propose to evaluate the electrochemistry of photoactive polythiophenes recently synthesised by us in a range of ionic liquids. This knowledge will be used to design and synthesise customised ionic liquids with the properties required to enhance the photoelectrochemical efficiency of devices based on substituted polythiophenes. We expect our findings to lead to the development of low-cost, flexible, organic photoelectrochemical cells.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100362
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Nanostructured metal hydrides for practical hydrogen storage applications. This project aims to synthesise nanostructured metal hydrides with particle size smaller than 5 nm. The practical applications of metal hydrides as advanced solid-state hydrogen storage materials require substantial knowledge and delicate engineering of materials on the nanoscale. Combined with controllable modification on the nanoscale, the optimised metal hydrides will enhance the performance of hydrogen storage materia ....Nanostructured metal hydrides for practical hydrogen storage applications. This project aims to synthesise nanostructured metal hydrides with particle size smaller than 5 nm. The practical applications of metal hydrides as advanced solid-state hydrogen storage materials require substantial knowledge and delicate engineering of materials on the nanoscale. Combined with controllable modification on the nanoscale, the optimised metal hydrides will enhance the performance of hydrogen storage materials. This project is expected to advance understanding of the technologies of metal hydrides as hydrogen storage materials and develop practical applications of metal hydrides in storage tanks for fuel cells. Hydrogen energy could also reduce carbon dioxide emissions and alleviate air pollution.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180101300
Funder
Australian Research Council
Funding Amount
$368,446.00
Summary
Probing interfacial impedance in all-solid-state lithium-ion batteries. This project aims to investigate the mechanism behind the high impedance at the interface between electrodes and the solid electrolyte in solid-state lithium-ion batteries using advanced in-situ transmission electron microscopy. The outcomes will deepen knowledge in chemical and structural evolution at the electrode–electrolyte interface during battery operation under different conditions, and thus inform the design and fabr ....Probing interfacial impedance in all-solid-state lithium-ion batteries. This project aims to investigate the mechanism behind the high impedance at the interface between electrodes and the solid electrolyte in solid-state lithium-ion batteries using advanced in-situ transmission electron microscopy. The outcomes will deepen knowledge in chemical and structural evolution at the electrode–electrolyte interface during battery operation under different conditions, and thus inform the design and fabrication of safe, high power, and long lasting solid-state batteries for a myriad of portable electronic devices and the emerging electric vehicles.Read moreRead less
Development of Nanocrystalline Transition Metal Oxide and Polymer-Transition Metal Oxide Composite Materials for Rechargeable Lithium Battery Applications. Recent work by the applicants has shown that nanocrystalline titanates and aluminates hold considerable promise as lithium battery electrodes. Nanocrystalline anatase materials showed considerably greater lithium intercalation ratios compared with their microcrystalline counterparts, and doping with vanadium showed further improvements in ....Development of Nanocrystalline Transition Metal Oxide and Polymer-Transition Metal Oxide Composite Materials for Rechargeable Lithium Battery Applications. Recent work by the applicants has shown that nanocrystalline titanates and aluminates hold considerable promise as lithium battery electrodes. Nanocrystalline anatase materials showed considerably greater lithium intercalation ratios compared with their microcrystalline counterparts, and doping with vanadium showed further improvements in capacity. Sol-gel synthesised V-doped anatase materials produced an initial discharge capacity of 428 Ah/kg compared with only 280 mAh/kg for the undoped anatase electrode in the same Li test cell.In this project different dopants and preparation conditions will be investigated to produce nanocrystalline rutile and aluminate materials as potential candidates for high capacity lithium battery applications.Read moreRead less