Transgenerational Effects Of Male Obesity - Mechanisms And Interventions
Funder
National Health and Medical Research Council
Funding Amount
$829,143.00
Summary
Childhood obesity is associated with obesity in either parent, and obese children tend to become obese adults, forming an intergenerational cycle that promotes obesity. We have identified paternal obesity as an important novel target for intervention to stop the progression of the obesity epidemic. This project investigates supplementation of obese fathers with folate to prevent the adverse impact of paternal obesity on subsequent generations.
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Deadly Commute - Targeting The Trafficking Mechanisms That Licence Inflammatory Cell Death
Funder
National Health and Medical Research Council
Funding Amount
$774,544.00
Summary
MLKL is a protein naturally found inside cells. MLKL is activated by inflammation. Once activated, MLKL relocates to the outer periphery of cells and kills them. Gut cells are especially vulnerable to death-by-MLKL and this problem causes Inflammatory Bowel Disease. Using cutting edge microscopy, we have discovered how MLKL moves to the periphery of cells prior to killing them. We will test if blocking this movement of MLKL to the cell periphery stops gut death and Inflammatory Bowel Disease.
Touch and Tension: Molecular Determinants of Human Mechanosensation . Feelings of touch and muscle tension are initiated by mechanosensory neurons found within the peripheral nervous system. Knowledge of human mechanosensory neurons has predominantly relied on rodent studies because of the limited availability of human tissue, which is not ideal. Our team has developed novel technologies for generating human mechanosensory neurons ‘in the dish’. The major aim of this project is to use human stem ....Touch and Tension: Molecular Determinants of Human Mechanosensation . Feelings of touch and muscle tension are initiated by mechanosensory neurons found within the peripheral nervous system. Knowledge of human mechanosensory neurons has predominantly relied on rodent studies because of the limited availability of human tissue, which is not ideal. Our team has developed novel technologies for generating human mechanosensory neurons ‘in the dish’. The major aim of this project is to use human stem cell-derived mechanosensory neurons as a platform to extensively study their molecular and functional properties. The significant benefits are the advancement of knowledge in the human mechanosensory system, which to date has been lacking, and in the long-term progress commercial development of novel drugs.Read moreRead less
The pressures of modern manhood. Mapping the impact of homophobia on the lives of Australian men. this study will construct a detailed map of the impact of homophobia on men;s behaviour, lifestyles and risk-taking (gay or not). It explores the possibility that through devices like taboo and loss of face homophobia can (i) make certain behaviours and life patterns unpalatable and alienate men from safer, healthier behaviours; (ii) block retreat from danger : and (iii) promote risky, antisocial, h ....The pressures of modern manhood. Mapping the impact of homophobia on the lives of Australian men. this study will construct a detailed map of the impact of homophobia on men;s behaviour, lifestyles and risk-taking (gay or not). It explores the possibility that through devices like taboo and loss of face homophobia can (i) make certain behaviours and life patterns unpalatable and alienate men from safer, healthier behaviours; (ii) block retreat from danger : and (iii) promote risky, antisocial, hyper-masculine posturing. from the innovative perspective of the interplay of homophobia with masculinity, we expect to uncover key insights into how homophobia makes an important contribution to the pressures of modern manhood.Read moreRead less
Gender, peacebuilding and the politics of space: a critical examination of United Nations peacebuilding practices. More than half of all peace agreements fail within five years. In response to this dismal statistic, the United Nations (UN) recently began to prioritise gender matters in peacebuilding operations, recognising that gender equality is key to building sustainable peace. This project examines how gender justice is addressed in United Nations peacebuilding policy and practice.
Domestic Subversions: maternalism and cross-cultural histories. This project will assist in the processes of reconciliation, by fostering a sense of a shared history, and increasing public awareness of the complexity of race relations histories in Australia. It will redress a significant gap in Australian knowledge and literature. Very little is known about the history of Aboriginal domestic workers and their relationships with their white employers in Australia, despite growing awareness of the ....Domestic Subversions: maternalism and cross-cultural histories. This project will assist in the processes of reconciliation, by fostering a sense of a shared history, and increasing public awareness of the complexity of race relations histories in Australia. It will redress a significant gap in Australian knowledge and literature. Very little is known about the history of Aboriginal domestic workers and their relationships with their white employers in Australia, despite growing awareness of the significance of domestic service in Aboriginal child removal policies. The project will also assist in establishing Australian historical scholarship at the forefront of leading international research initiatives in gender, race and colonialism studies. Read moreRead less
Inner Eurasia: A World History of Eurasia's Heartlands. Inner Eurasia has played a distinctive and significant role in world history, particularly in the twentieth century when it was the heartland of world communism. Australia's history has been shaped profoundly by the political, military, cultural and commercial impact of the region's great empires. This project will expand Australian understanding of the region, and raise Australia's international visibility and competitiveness in both Inner ....Inner Eurasia: A World History of Eurasia's Heartlands. Inner Eurasia has played a distinctive and significant role in world history, particularly in the twentieth century when it was the heartland of world communism. Australia's history has been shaped profoundly by the political, military, cultural and commercial impact of the region's great empires. This project will expand Australian understanding of the region, and raise Australia's international visibility and competitiveness in both Inner Eurasian and World history. It will attract undergraduate and graduate students and international scholars. Its world history approach will augment Macquarie's significant contributions to the Australian National History Curriculum.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100569
Funder
Australian Research Council
Funding Amount
$438,175.00
Summary
Mapping fertility control among migrant and refugee women in Australia. This project aims to increase understanding of fertility control among migrant and refugee women living in Australia. This vulnerable group of women report low rates of contraception use and high rates of unintended pregnancy, with significant negative health implications. This project will examine women’s negotiation of fertility control, within the context of broader sexual and reproductive embodiment. It will provide nove ....Mapping fertility control among migrant and refugee women in Australia. This project aims to increase understanding of fertility control among migrant and refugee women living in Australia. This vulnerable group of women report low rates of contraception use and high rates of unintended pregnancy, with significant negative health implications. This project will examine women’s negotiation of fertility control, within the context of broader sexual and reproductive embodiment. It will provide novel insight into women’s negotiation of contraception choice and sides effects, abortion and reproductive coercion, recognising women’s agency, across a range of cultural contexts and backgrounds. These findings will provide recommendations for culturally meaningful health promotion activities and healthcare provision.Read moreRead less
Engaging Men and Boys in Violence Prevention: Effective directions for practice. Violence against women is a significant issue of policy effort and community concern. In the past decade, there has been an increasing emphasis on the need to engage men and boys in preventing and reducing men’s violence against women, both nationally and internationally. However, little is known about what works and does not work. Using robust evaluations of key strategies and interventions, this project aims to pr ....Engaging Men and Boys in Violence Prevention: Effective directions for practice. Violence against women is a significant issue of policy effort and community concern. In the past decade, there has been an increasing emphasis on the need to engage men and boys in preventing and reducing men’s violence against women, both nationally and internationally. However, little is known about what works and does not work. Using robust evaluations of key strategies and interventions, this project aims to produce a systematic framework for effective practice in engaging men and boys in preventing violence against women. It aims to produce both significant scholarly insights regarding gender and violence prevention and practical directions for policy and programming.Read moreRead less