Probiotic Prawn Oral Immunotherapy (ProPIT) For Treatment Of Prawn Allergy
Funder
National Health and Medical Research Council
Funding Amount
$1,865,369.00
Summary
A ‘curative’ food allergy treatment is needed to prevent deaths and improve care. We recently showed that probiotic peanut oral immunotherapy (PPOIT) was highly effective for treating peanut allergy. 82% of PPOIT treated children gained tolerance compared to 4% of the placebo group. We will now test the combined probiotic-food OIT approach for treating prawn allergy. If successful, we will have identified the first treatment for prawn allergy and a platform treatment for other food allergies.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100079
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
A thermally stratified Sea-Ice-Wave Interaction Facility. A thermally stratified sea ice wave interaction facility: Predictions of climate change now impact all levels of society as future political, social and environmental plans are made on the basis of these models. Predictions require models of many complex dynamical processes with a wide range of parameters. An important process is the Marginal Ice Zone (MIZ) dynamics. The MIZ is the region between the open ocean and the fully ice-covered o ....A thermally stratified Sea-Ice-Wave Interaction Facility. A thermally stratified sea ice wave interaction facility: Predictions of climate change now impact all levels of society as future political, social and environmental plans are made on the basis of these models. Predictions require models of many complex dynamical processes with a wide range of parameters. An important process is the Marginal Ice Zone (MIZ) dynamics. The MIZ is the region between the open ocean and the fully ice-covered ocean where waves and ice interact, causing ice-breaking and wave attenuation. This unique facility will enable experiments in sea-ice-wave interactions in a controlled environment. Water and air temperature, thermal stratification, water waveform and ice properties will be adjusted in order to preserve key characteristics of the complex ocean environment.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100220
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
Sonic drilling to provide contamination-free core sampling of rock and unconsolidated sediment. Australia is the world's driest inhabited continent. Understanding environmental and climatic changes, from the temperate period when humans arrived about 50,000 years ago to the present state of widespread aridity, is crucial for modelling future climate change. This facility will provide new generation drilling equipment which is necessary to obtain accurate records.
The application of clumped isotope thermometry to the terrestrial environment. Clumped-isotope geochemistry, a novel method for measuring the temperature of formation of carbonate minerals, will be applied to terrestrial materials (soil carbonates, lake deposits and speleothems) from Australia and New Zealand. The method relates the abundance or 'clumping' of rare isotopes (for example, carbon dioxide of mass 47 as carbon-13, oxygen-18, oxygen-16) extracted from carbonates to their formation tem ....The application of clumped isotope thermometry to the terrestrial environment. Clumped-isotope geochemistry, a novel method for measuring the temperature of formation of carbonate minerals, will be applied to terrestrial materials (soil carbonates, lake deposits and speleothems) from Australia and New Zealand. The method relates the abundance or 'clumping' of rare isotopes (for example, carbon dioxide of mass 47 as carbon-13, oxygen-18, oxygen-16) extracted from carbonates to their formation temperature and is independent of the oxygen-18:oxygen-16 value of the host water from which the mineral precipitated. The materials to be investigated span the Last Glacial-Interglacial Transition and will provide robust past temperature estimates and the delta-oxygen-18 values of waters, thereby permitting hydrological balances (for example, precipitation/evaporation) to be constructed. Read moreRead less
Novel plastics using renewable signal chemistry to remove bacteria in water. This project plans to develop synthetic plastic surfaces that continuously generate nitric oxide to deter the formation of biofilms. Plastic surfaces exposed to aqueous environments rapidly become covered by a film of bacteria, which can cause infection. Trace levels of generated nitric oxide can combat this problem by breaking up existing bacterial biofilms. Current research has developed plastics that continuously gen ....Novel plastics using renewable signal chemistry to remove bacteria in water. This project plans to develop synthetic plastic surfaces that continuously generate nitric oxide to deter the formation of biofilms. Plastic surfaces exposed to aqueous environments rapidly become covered by a film of bacteria, which can cause infection. Trace levels of generated nitric oxide can combat this problem by breaking up existing bacterial biofilms. Current research has developed plastics that continuously generate nitric oxide, but not for extended periods of time. This project’s approach is significant because it avoids bacterial resistance to the nitric oxide treatment. Applications of this technology may include removing biofilms from environments such as water filtration devices and consumable medical surfaces.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100067
Funder
Australian Research Council
Funding Amount
$10,000,000.00
Summary
Australian Membership of the International Ocean Discovery Program. Australian membership of the International Ocean Discovery Program:
This project is for a 5-year membership of the International Ocean Discovery Program, the world’s largest collaborative research program in earth and ocean sciences addressing international priorities. The program conducts seagoing coring expeditions and monitoring of instrumented boreholes to study the history and current activity of the Earth, recorded in sed ....Australian Membership of the International Ocean Discovery Program. Australian membership of the International Ocean Discovery Program:
This project is for a 5-year membership of the International Ocean Discovery Program, the world’s largest collaborative research program in earth and ocean sciences addressing international priorities. The program conducts seagoing coring expeditions and monitoring of instrumented boreholes to study the history and current activity of the Earth, recorded in sediments and rocks below the seafloor. The program’s aims include understanding past global environments on multiple time scales, the deep biosphere, plate tectonics, occurrence and distribution of resources, and generation of hazards. Several multinational expeditions are scheduled and planned in our marine jurisdiction and within the Australasian region. Read moreRead less
A spatial extremes framework for predicting subdaily rainfall intensity. Climate change is causing extreme rainfall intensity to increase globally. The greatest increases occur for short-duration storms lasting up to several hours, bringing a heightened risk of flash-floods that are often extremely hazardous due to their rapid onset. The project aims to develop a new spatial extreme value framework to predict extreme rainfall patterns, using insights on future changes to rainfall triggering mech ....A spatial extremes framework for predicting subdaily rainfall intensity. Climate change is causing extreme rainfall intensity to increase globally. The greatest increases occur for short-duration storms lasting up to several hours, bringing a heightened risk of flash-floods that are often extremely hazardous due to their rapid onset. The project aims to develop a new spatial extreme value framework to predict extreme rainfall patterns, using insights on future changes to rainfall triggering mechanisms (e.g. convective, frontal or orographic). The research aims to provide projections in the form of intensity-frequency-duration curves, areal reduction factors and antecedent rainfall depths. Engineers are expected to use this information to design infrastructure and urban planning policies to adapt to future flood risk.Read moreRead less
Keystone microbes and planktonic guilds in Australia's oceans. This project aims to unveil the ocean’s hidden sentinels, “keystone microbes” that underpin precious ecosystem services, and which can be used to monitor and model changes in ocean function. Marine microbes account for 90 per cent of oceanic biomass and every litre of seawater contains ~20,000 different species, but it is not known which species control ocean health and productivity. This project intends to provide definitive evidenc ....Keystone microbes and planktonic guilds in Australia's oceans. This project aims to unveil the ocean’s hidden sentinels, “keystone microbes” that underpin precious ecosystem services, and which can be used to monitor and model changes in ocean function. Marine microbes account for 90 per cent of oceanic biomass and every litre of seawater contains ~20,000 different species, but it is not known which species control ocean health and productivity. This project intends to provide definitive evidence of these keystones’ cellular level biogeochemical and metabolic capacity. Ultimately, this knowledge is expected to predict the resilience of ocean ecosystems and their response to change. The capacity to predict their dynamics will help provide investment clarity and increase healthy outcomes from activities involving human-ocean interactions such as recreation, food production and tourism.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100047
Funder
Australian Research Council
Funding Amount
$3,600,000.00
Summary
Australian Membership of the International Ocean Discovery Program. Australian membership of the International Ocean Discovery Program: This project is for an Australian membership of the International Ocean Discovery Program. The Program will recover drill cores, situate observatories, and conduct down-hole experiments in all the world's oceans from lowest to highest latitudes to address fundamental questions about Earth's history and processes within four high-priority scientific themes: clima ....Australian Membership of the International Ocean Discovery Program. Australian membership of the International Ocean Discovery Program: This project is for an Australian membership of the International Ocean Discovery Program. The Program will recover drill cores, situate observatories, and conduct down-hole experiments in all the world's oceans from lowest to highest latitudes to address fundamental questions about Earth's history and processes within four high-priority scientific themes: climate and ocean change - reading the past and informing the future; biosphere frontiers - deep life, biodiversity, and environmental forcing of ecosystems; earth connections - deep processes and their impact on earth's surface environment; earth in motion - processes and hazards on a human time scale.Read moreRead less
Development and Modellling of Advanced Coagulation and Oxidation Processes. The success of this program will help place Australia at the forefront of water quality control and management research. It will address concerns with managing and treating waters of changing characteristics due to climate change. In addition to the socio benefits, project success will also impart economic benefits to the nation through (i) fabricating new hybrid coagulants, that are versatile with enhanced performance ....Development and Modellling of Advanced Coagulation and Oxidation Processes. The success of this program will help place Australia at the forefront of water quality control and management research. It will address concerns with managing and treating waters of changing characteristics due to climate change. In addition to the socio benefits, project success will also impart economic benefits to the nation through (i) fabricating new hybrid coagulants, that are versatile with enhanced performance for removing NOM, and possess antimicrobial properties (ii) developing a new energy efficient photocatalysis technology.The proposed research will expand the knowledge base in this area and increase Australia’s international profile as a global leader in developing cutting-edge cost effective water resource technologies.Read moreRead less