Microbial Restoriation In Crohn's Disease: A Randomised Trial Of Faecal Microbial Transplanatation In Crohn's Disease
Funder
National Health and Medical Research Council
Funding Amount
$487,123.00
Summary
Crohn's disease causes inflammation and damage to the digestive tract. Compelling evidence suggests that the bacteria in the gut play an important role in the onset of disease. Changing the gut bacteria through the administration of healthy stool to a patient, faecal microbiota transplantation (FMT), is safe and may be effective. This placebo controlled trial will determine whether FMT (delivered via capsule) can control inflammation in Crohn's. Results will change current treatment paradigms.
A La CaRT: Australasian Laparoscopic Cancer Of The Rectum Trial. A Phase III Prospective Randomised Trial Comparing Laparoscopic-assisted Resection Versus Open Resection For Rectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$599,054.00
Summary
The major treatment for rectal cancer is surgical removal of tumour with a large cut through the abdomen. There is a newer, less invasive procedure known as laparoscopic resection which enables the same surgery to be performed using a scope inserted in the abdomen and another smaller incision for removal of the tumour. This study is being conducted to determine whether the newer procedure is as safe and effective as the current procedure. Patients on the trial will be given either laparoscopi
Optimising Therapy In Anti-neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis
Funder
National Health and Medical Research Council
Funding Amount
$124,676.00
Summary
ANCA vasculitis is a rare autoimmune condition causing inflammation in small blood vessels, that can lead to organ failure and death. This research will help identify the best treatment approach for different subgroups of patients and the best timing of certain treatments. We will also explore patient symptoms and experience of this condition, and how this relates to disease activity, damage and medication effects.
Randomised Control Trial Of Three Treatments For Adolescent Stutterers
Funder
National Health and Medical Research Council
Funding Amount
$376,320.00
Summary
Effective communication is an essential of everyday life, and stuttering impairs this function. Those who stutter may find effective communication impossible, and severe cases may be rendered almost mute. Clinically significant anxiety figures prominently in the disorder with almost half of those seeking treatment warranting a comorbid diagnosis of social phobia. The adolescent years are generally regarded as a difficult time of life, at which time the potential effects of disfigured speech can ....Effective communication is an essential of everyday life, and stuttering impairs this function. Those who stutter may find effective communication impossible, and severe cases may be rendered almost mute. Clinically significant anxiety figures prominently in the disorder with almost half of those seeking treatment warranting a comorbid diagnosis of social phobia. The adolescent years are generally regarded as a difficult time of life, at which time the potential effects of disfigured speech can be devastating. There has been much research and development of treatments for children and adults who stutter, proven effective treatments are available for those age groups. However, little is known about how to treat adolescents who stutter, and there has been little research and development to find the best treatment-s for this age group. The present proposal is for a randomised, controlled trial of three treatments that have been shown recently to have promise as treatment methods for this age group of patients. The trial will compare (1) a treatment that involves biofeedback muscle activity during speech, (2) a treatment that involves biofeedback of voice box activity during speech, and (3) a variant of a standard treatment that trains the speaker in a new speech pattern. The control group will receive no treatment. The trial extends for a period of 12 months after the subjects are randomly allocated to a treatment group or a control group. The subjects' speech will be assessed in a variety of situations in the clinic and during everyday life. The prime outcome measure will be percentage of syllables stuttered, and secondary measures will be the time required for treatment and how natural the patients sound after treatment. At the conclusion of the trial, the subjects in the control group will be given the treatment that was shown to be most effective.Read moreRead less
Improving Outcomes In Obstructive Sleep Apnoea Through Individualised Treatment Of Physiological Abnormalities
Funder
National Health and Medical Research Council
Funding Amount
$340,891.00
Summary
The most common treatment for obstructive sleep apnoea, continuous positive airway pressure, is only accepted by ~50% of patients. Individualised treatment options are urgently needed. In order to predict who will benefit from the common alternative therapies, my research will show how, upper airway surgery improves obstructive sleep apnoea at an individual level and develop tools that will help clinicians select patients for these therapies.
A New, Low-cost E-health Treatment For Alcohol Use Disorder Using Mental Imagery
Funder
National Health and Medical Research Council
Funding Amount
$895,032.00
Summary
This project offers the first large-scale test of phone-based Functional Imagery Training (FIT), a new, low-cost way to help people change behaviours using mental imagery, regardless of where they live. The trial addresses Alcohol Use Disorder—a common problem with substantial health and social impacts, comparing FIT with verbal motivational treatments, and testing effects on alcohol use and quality of life over 12 months. Cost-effectiveness and predictions of outcome are also examined.
Prevention Of Multi-drug Resistant Tuberculosis In A High Prevalence Setting: ‘Connecting The DOTS’ In Vietnam
Funder
National Health and Medical Research Council
Funding Amount
$3,382,020.00
Summary
The close contacts of people with multi-drug resistant tuberculosis (MDR-TB) have a high risk of developing the disease. The V-QUIN MDR-TB Trial will evaluate the effectiveness of an oral antibiotic (levofloxacin) in preventing drug resistant TB among infected household contacts of TB patients. Household contacts from 10 Provinces in Vietnam will be randomly allocated to receive six-months of either levofloxacin or a placebo, and then followed for two years to see if they develop tuberculosis.
Centre Of Research Excellence In Indigenous Children's Healthy EARs (ICHEAR)
Funder
National Health and Medical Research Council
Funding Amount
$2,615,897.00
Summary
The overwhelming burden of otitis media (middle ear inflammation, OM) and the consequences of hearing loss on social and educational outcomes in Indigenous children are indisputable. Our CRE_ICHEAR is a multidisciplinary group of Australia’s experts in OM research, policy and practice guidelines. The CRE will derive better value in terms of discovery, translation and sustainability. Increased Indigenous leadership will raise awareness and advocacy, with greater efficiency of research translation
Improving Access To Psychological Treatment And The Mental Health Of Australians With Chronic Physical Disease.
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
Most Australians will have to manage one or more chronic health conditions in their lifetime. Poor mental health is known to significantly compromise the medical treatment, self-management and, thus, the prognosis of adults with chronic physical disease. The proposed fellowship seeks to address three critical knowledge gaps limiting our ability to support the mental health of Australians with chronic physical diseases.