X-RATE: A Novel Radiation Detector Platform To Realize New Opportunities In Radiotherapy At The Australian Synchrotron
Funder
National Health and Medical Research Council
Funding Amount
$347,541.00
Summary
Microbeam Radiation Therapy (MRT) is an emerging X-ray radiosurgery modality that offers new hope for the treatment of brain cancer and other human brain diseases. A tissue equivalent radiation dosimetry system is essential for upcoming MRT human trials to precisely verify treatment plans. We are recognized world leaders in real-time silicon detector instrumentation for radiation dosimetry. We plan to develop and demonstrate X-RATE, the X-ray Real-time Active Tissue Equivalent dosimeter.
Therapeutic Treatment Pathways And Their Impact On Medicine Safety And Effectiveness
Funder
National Health and Medical Research Council
Funding Amount
$336,070.00
Summary
In clinical trials medicines are assumed to be used regularly with a set dose over the duration of the study. However, in real life medicines are used in different doses, over different durations and together with other medicines, which affect the effectiveness and safety of the treatment. The aim of this proposed research is to evaluate how different treatment pathways impact medicine safety and effectiveness. This project will provide new information on safety and effectiveness of treatment pa ....In clinical trials medicines are assumed to be used regularly with a set dose over the duration of the study. However, in real life medicines are used in different doses, over different durations and together with other medicines, which affect the effectiveness and safety of the treatment. The aim of this proposed research is to evaluate how different treatment pathways impact medicine safety and effectiveness. This project will provide new information on safety and effectiveness of treatment pathways.Read moreRead less
Development Of A Molecular Point-of-care Test For Hepatitis C To Increase Uptake Of Curative Antiviral Treatment
Funder
National Health and Medical Research Council
Funding Amount
$781,353.00
Summary
This project seeks to develop a new point-of-care test to detect hepatitis C virus infections. This will enable the diagnosis and initiation of curative treatment in a single healthcare visit. It is expected that this will overcome a major barrier to treating high-risk groups with these highly effective medications and will lead to higher number of cured patients.
A Computerised Treatment Planning System For Synchrotron Radiotherapy Trials At The Australian Synchrotron’s Imaging & Medical Beamline.
Funder
National Health and Medical Research Council
Funding Amount
$646,812.00
Summary
Microbeam Radiotherapy (MRT) using synchrotron-generated X-rays has shown tremendous promise in pre-clinical trials in tumour-bearing rodents, with remarkable sparing of normal tissue. Synchrotron MRT has the potential to radically alter the way radiotherapy is performed for human cancers. Every radiotherapy patient undergoes some form of computerised treatment planning before their treatment starts. We aim to test and implement a synchrotron Treatment Planning System, as an essential step in re ....Microbeam Radiotherapy (MRT) using synchrotron-generated X-rays has shown tremendous promise in pre-clinical trials in tumour-bearing rodents, with remarkable sparing of normal tissue. Synchrotron MRT has the potential to radically alter the way radiotherapy is performed for human cancers. Every radiotherapy patient undergoes some form of computerised treatment planning before their treatment starts. We aim to test and implement a synchrotron Treatment Planning System, as an essential step in realising synchrotron radiotherapy trials.Read moreRead less
Blocking The Factor XII- Kallikrein Pathway To Limit Abdominal Aortic Aneurysm
Funder
National Health and Medical Research Council
Funding Amount
$686,995.00
Summary
Artery weakening is present in 2-5% of older adults and is an important cause of sudden death. The investigators have generated substantial preliminary data from a previous NHMRC project implicating the contact pathway in the process of artery weakening. In the current project the investigators will examine the ability of agents which are currently available or being developed for patient use in limiting the process of artery degeneration using established pre-clinical models.
ASTROID: Active Surveillance And Other TReatment OptIons For Prostate Cancer. A Randomised Controlled Trial Of Decision Aid And DVD Information Support For Men Diagnosed With Low-risk Prostate Cancer And Their Partners
Funder
National Health and Medical Research Council
Funding Amount
$782,369.00
Summary
This summary was provided in the grant application.
The Australian, Imaging, Biomarkers And Lifestyle Study Of Ageing (AIBL) Phase III - Facilitating Early Intervention In Preclinical Alzheimer's Disease.
Funder
National Health and Medical Research Council
Funding Amount
$733,653.00
Summary
Amyloid brain scans can detect the onset of Alzheimer's disease 10-15 years before symptoms first appear. Amyloid build-up is thought to be the cause of Alzheimer's disease. The earlier that drugs designed to slow the build up of amyloid or to clear it from the brain are given, the greater the chance of benefit. This study will use the recent discoveries from the Australian AIBL study to develop the best method to find these people with brain amyloid but no symptoms for early treatment trials to ....Amyloid brain scans can detect the onset of Alzheimer's disease 10-15 years before symptoms first appear. Amyloid build-up is thought to be the cause of Alzheimer's disease. The earlier that drugs designed to slow the build up of amyloid or to clear it from the brain are given, the greater the chance of benefit. This study will use the recent discoveries from the Australian AIBL study to develop the best method to find these people with brain amyloid but no symptoms for early treatment trials to prevent dementia.Read moreRead less
PET Imaging Agents For The Differential Diagnosis Of Hypoxic Tumors
Funder
National Health and Medical Research Council
Funding Amount
$585,429.00
Summary
Choosing the best type of treatment from the ever increasing arsenal of chemotherapeutic agents against cancer is of critical importance. Tumor hypoxia requires specialized treatment and patient selection. Current PET imaging agents cannot differentiate between severely and mildly hypoxic tumors. We have found a new agent that can detect mildly hypoxic tumors and the aim of this grant application is to further develop this radiotracer to improve image quality and reliability of the diagnosis.