Emulsion Stability and Solvent Extraction Equipment Design in the Pharmaceutical Industry. The project aims at developing reliable prediction of large scale performance of liquid extraction columns. This will be done through a study of the columns in operation at GlaxoSmithKline's operation at Port Fairy alkaloids plant. In addition a detailed study of the influence of impurities on the coalescence rate of liquid dispersions will be undertaken as this is an important rate limiting step in colu ....Emulsion Stability and Solvent Extraction Equipment Design in the Pharmaceutical Industry. The project aims at developing reliable prediction of large scale performance of liquid extraction columns. This will be done through a study of the columns in operation at GlaxoSmithKline's operation at Port Fairy alkaloids plant. In addition a detailed study of the influence of impurities on the coalescence rate of liquid dispersions will be undertaken as this is an important rate limiting step in column performance. The benefit to GlaxoSmithKline will be a more efficient and optimised plant. The benefit to Australian processing industries is a reliable method of relating small scale trials to full size column performance which is a significent problem in the minerals industry at present.Read moreRead less
Next Generation of Separation Equipment for Natural Product Extraction. The benefit to GlaxoSmithKline will be the potential to upgrade to a more efficient plant which is important for maintaining their competitive position in this global business. The benefit to other Australian processing industries will be an improved understanding of the performance of membrane contactors when used for natural product separation and more specifically a reliable method for controlling fouling in this type of ....Next Generation of Separation Equipment for Natural Product Extraction. The benefit to GlaxoSmithKline will be the potential to upgrade to a more efficient plant which is important for maintaining their competitive position in this global business. The benefit to other Australian processing industries will be an improved understanding of the performance of membrane contactors when used for natural product separation and more specifically a reliable method for controlling fouling in this type of equipment which is a currently a significant industry problem.Read moreRead less
Environmentally Sustainable Solvents for Natural Pharmaceutical Extraction Processes. Australia supplies 25 per cent of the world's pain relieving medicinal opiates which contributes to a $200 million export industry for Australia. The active pharmaceutical ingredients are extracted and purified at GlaxoSmithKline’s (GSK) Port Fairy processing plant using a solvent extraction based process. Together with GSK the project team aim to examine the use of environmentally sustainable bio-derived natur ....Environmentally Sustainable Solvents for Natural Pharmaceutical Extraction Processes. Australia supplies 25 per cent of the world's pain relieving medicinal opiates which contributes to a $200 million export industry for Australia. The active pharmaceutical ingredients are extracted and purified at GlaxoSmithKline’s (GSK) Port Fairy processing plant using a solvent extraction based process. Together with GSK the project team aim to examine the use of environmentally sustainable bio-derived natural solvents to replace the volatile organic compound (VOC) fossil fuels based solvents used in the current process. Due to environmental and health concerns associated with VOCs the development of alternative solvents will be of great benefit to not only GSK but a range of other processing industries that also use VOC based solvent extraction processes.Read moreRead less
Discrete Element Method for Analysis and Design of Pharmaceutical Encapsulation. Tablets represent the preferred method of dose delivery in the pharmaceutical industry, with over 80% of the market. PressFit - gelcaps have recently been developed, which encase a tablet core within a gelatin coating. The product combines the consumer appeal of capsules with the processing convenience of tablets, and provides a high degree of tamper-resistance. An important issue is that the caplets are required ....Discrete Element Method for Analysis and Design of Pharmaceutical Encapsulation. Tablets represent the preferred method of dose delivery in the pharmaceutical industry, with over 80% of the market. PressFit - gelcaps have recently been developed, which encase a tablet core within a gelatin coating. The product combines the consumer appeal of capsules with the processing convenience of tablets, and provides a high degree of tamper-resistance. An important issue is that the caplets are required to have very precise dimensional precision, an issue not previously of high priority for tabletting . This project seeks to enhance the competitive advantage of this new technology, through a combination of advanced mathematical modeling supported by experiments.Read moreRead less
Particle design and recovery of bioactives by crystallisation and precipitation. This project will develop new strategies for economically viable recovery of bioactives from complex solutions of biomaterials eg. separation of biopharmaceuticals from genetically engineered cell culture, food ingredient processing, functional food and nutraceutical extraction from natural sources. Crystallisation and precipitation will be used as primary separation techniques. We propose a new paradigm in which ....Particle design and recovery of bioactives by crystallisation and precipitation. This project will develop new strategies for economically viable recovery of bioactives from complex solutions of biomaterials eg. separation of biopharmaceuticals from genetically engineered cell culture, food ingredient processing, functional food and nutraceutical extraction from natural sources. Crystallisation and precipitation will be used as primary separation techniques. We propose a new paradigm in which molecular studies of protein interactions will be used to predict good crystallisation conditions and linked to process crystalliation studies. Studies will use a model system of egg white protein mixtures and a real system of industrial importance - the purification of valuable protein products from soy beans (valued at $500 million per year world wide). Soy beans studies will include pilot scale tests at Dupont's industrial reseach laboratories.Read moreRead less
High Gravity Precipitation of Nanoparticles for Pulmonary Drug Delivery. This collaborative project aims to explore the huge market potential of drug delivery by inhalation aerosols using nanoparticles. It will apply cutting edge nanotechnology to develop new techniques using high gravity to synthesise particles of biomaterials suitable for inhalation. Nanoparticles can penetrate deeper into the lung where they deposit and dissolve faster for enhanced therapeutic effects. Successful developme ....High Gravity Precipitation of Nanoparticles for Pulmonary Drug Delivery. This collaborative project aims to explore the huge market potential of drug delivery by inhalation aerosols using nanoparticles. It will apply cutting edge nanotechnology to develop new techniques using high gravity to synthesise particles of biomaterials suitable for inhalation. Nanoparticles can penetrate deeper into the lung where they deposit and dissolve faster for enhanced therapeutic effects. Successful development of the technology will position both Australia and the industry partner to take a lead in the application of this novel technology in pharmaceutical aerosols, and provides better inhalation therapy to benefit patients.Read moreRead less
Scale-up and Intelligent Control of Granulation Processes. Granulation is the process that forms granular products with carefully targeted properties from powdery or liquid feeds. Granular products abound in the pharmaceutical, agricultural & industrial chemicals, and food & consumer goods industries. Poor understanding of the granulation causes delays in the time to market of new products and poor efficiency in large scale continuous granulation plants. This project will build on recent adva ....Scale-up and Intelligent Control of Granulation Processes. Granulation is the process that forms granular products with carefully targeted properties from powdery or liquid feeds. Granular products abound in the pharmaceutical, agricultural & industrial chemicals, and food & consumer goods industries. Poor understanding of the granulation causes delays in the time to market of new products and poor efficiency in large scale continuous granulation plants. This project will build on recent advances in the understanding of granulation fundamentals to (1) develop new robust design and scale up rules (2) develop intelligent control schemes for continuous granulation circuits, and (3) develop a new generation of regime separated granulators. The project is receiving substantial support from 3 industry partners (MSD Australia, Incitec and WMC Fertilizers) with cash contributions over 40% of the ARC grant requested, as well as very substantial in-kind contributions.Read moreRead less