Development Of Non-surgical Approach To Treating Tricuspid Regurgitation
Funder
National Health and Medical Research Council
Funding Amount
$266,427.00
Summary
Heart failure is a common problem in which the heart enlarges and contracts poorly. In association with enlargement of the heart, the heart valves also begin to fail causing further worsening of quality and length of life. Failure of the tricuspid valve occurs in upto 87% of patients with heart failure and presently the only treatment option is high risk heart surgery. We are developing a way of dealing with tricuspid valve failure that does not require cardiac surgery.
Clinical, Pathological And Genetic Basis Of Familial Valvular Heart Disease
Funder
National Health and Medical Research Council
Funding Amount
$133,351.00
Summary
Mitral valve prolapse and bicuspid aortic valve are two common valve syndromes that are characterized by remarkable clinical diversity, ranging from no symptoms to potentially life threatening complications, heart failure and sudden death. Both disorders seem to run in families in a significant proportion of patients and thus are likely to have genetic causes, which remains unknown to date. This project aims to identify the underlying genetic basis of these common familial valve syndromes.
Anatomy, Epidemiology And Aetiology Of Tricuspid Valve Disease And Its Impact On The Development Of Emerging Transcatheter Therapies
Funder
National Health and Medical Research Council
Funding Amount
$88,662.00
Summary
Tricuspid valve disease is common, associated with poor prognosis and has few available treatment options. The aim of this project is to improve our understanding of the burden of tricuspid valve disease, and the factors that drive its occurrence and progression. We also aim to improve our practice of pacemaker/defibrillator insertion (which can injury the tricuspid valve). Our investigations will help inform improvement in the treatment of this condition, including minimally invasive options.
Improving Cardiac Valve Implant Outcomes With Advanced Computer Simulation
Funder
National Health and Medical Research Council
Funding Amount
$593,367.00
Summary
This project focuses on improving heart valve procedures, specifically focusing on new transcatheter techniques of heart valve implantation. The research uses advanced imaging and computer simulation techniques to predict the outcome and improve minimally invasive heart procedures.
The Influence Of Transcatheter Aortic Valve Implantation On Myocardial Structure And Function
Funder
National Health and Medical Research Council
Funding Amount
$110,218.00
Summary
Transcatheter aortic valve implantation has given options to elderly patients who were previously faced with an open-heart operation. Our research utilises CT scans to determine the anatomical and physiological effects this new technology has on the heart. This research will help to guide the ongoing development and refinement of this technology. The research has the potential to revolutionise how aortic stenosis is assessed and timing of intervention is determined.
Novel Multi-Modality Assessment Of Arrhythmic Risk And Disease Progression In Repaired Tetralogy Of Fallot Undergoing Redo-Pulmonary Valve Surgery Using 4D Cardiac MRI Flow And High Density 3D Electro-Anatomical Mapping.
Funder
National Health and Medical Research Council
Funding Amount
$110,703.00
Summary
Sudden death from arrhythmia is the most common cause of death in adults with tetralogy of Fallot, a type of congenital heart disease. It has been shown that dangerous arrhythmias can be induced in almost half of these patients when severe pulmonary valve disease is present. Our study will evaluate the potential for arrhythmias both before and after pulmonary valve surgery, using MRI and electrophysiological testing, to determine if these patients require defibrillators.
Phospholipase Cbeta 1b, A Target To Limit Atrial Dilatation
Funder
National Health and Medical Research Council
Funding Amount
$544,847.00
Summary
We have identified a heart specific protein that is involved in perpetuating dilatation of the upper chambers of the heart and thereby contributing to cardiac disease. Inhibitors of this protein provide a suitable target for therapy to limit heart disease. The current studies aim to test such inhibitors in vivo as proof-of-concept that such treatment effectively limits cardiac dysfunction.
Valvular heart disease is a common cause of heart failure. Identification of the genetic causes of valvular heart disease has important implications in our understanding of these heart diseases, as well as translating these genetic discoveries into better diagnostic and prevention strategies in at-risk families. This research proposal seeks to perform a comprehensive clinical and genetic investigation of individuals and families with the two most common valvular heart diseases, mitral valve prol ....Valvular heart disease is a common cause of heart failure. Identification of the genetic causes of valvular heart disease has important implications in our understanding of these heart diseases, as well as translating these genetic discoveries into better diagnostic and prevention strategies in at-risk families. This research proposal seeks to perform a comprehensive clinical and genetic investigation of individuals and families with the two most common valvular heart diseases, mitral valve prolapse and congenital bicuspid aortic valve.Read moreRead less
SHANK3 As A Target To Reduce Hypertrophy And Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$548,908.00
Summary
We have identified a large protein in heart that functions to facilitate the heart's response to disease. The proposed studies will define how this protein mediates responses and whether we can successfully interfere with the process to limit disease progression.