Feasibility Of Using Pre-hospital Point-of-care Troponin And Paramedic Risk Assessment In Patients With Chest Pain Without ST-elevation
Funder
National Health and Medical Research Council
Funding Amount
$132,743.00
Summary
Non-traumatic chest pain is the leading cause of ambulance services use in Victoria. Currently, there is no protocol for paramedics to determine which patients are high risk and suffering a minor heart attack, which results in delays in treatment. The aim of this project is to assess the feasibility of a risk assessment tool, including the use of point-of-care blood testing to detect heart attacks, to accurately risk stratify chest pain patients in the pre-hospital setting.
Improving Rapid Decision-Making In The Face Of Uncertainty: A Randomised Trial Of A 1-hour Troponin Protocol In Suspected Acute Coronary Syndromes
Funder
National Health and Medical Research Council
Funding Amount
$1,095,320.00
Summary
Chest pain patients are a large burden of emergency department demand. Their effective care requires timely risk assessment. High-sensitivity assays for heart muscle damage (troponin) increases the ability to detect patients at low risk for heart attack but treatment rules based on these tests have not been fully validated. This randomised trial of clinical decision making based on new troponin tests will provide a guidelines for their efficient and effective use in emergency department care.
The Limit Of Detection In The Emergency Department Trial: A Stepped-wedge Cluster Randomised Trial For Rapid Assessment Of Patients With Suspected Acute Coronary Syndrome In The Emergency Department
Funder
National Health and Medical Research Council
Funding Amount
$532,120.00
Summary
Over 450,000 patients present to Australian emergency departments with chest pain every year. The current approach to rule out heart attack for these patients is lengthy, costly and creates overcrowding in the emergency department. This is not sustainable in a system with growing demand and finite resources. This study will evaluate a rapid assessment pathway for investigating chest pain in the emergency department. The pathway will reduce healthcare utilisation while retaining patient safety.
Development Of A Sensitive Point Of Care Diagnostic Assay For Troponin I
Funder
National Health and Medical Research Council
Funding Amount
$137,650.00
Summary
This research aims to develop a diagnostic for immediate monitoring of patients presenting with chest pain, with the presumption of heart attack. The novel diagnostic platform will enable the estimation of a key indicator of heart muscle damage to be performed within a ten to fifteen minute window. This will aid speedier diagnosis and propoer triage of patients presenting with chest pain.
The Structural Basis For The Control Of Cardiac And Skeletal Muscle By The Troponin Complex
Funder
National Health and Medical Research Council
Funding Amount
$369,003.00
Summary
Many key physiological processes are controlled by large, multi-protein complexes. These molecular machines ensure that signals transmitted in the body are correctly interpreted and amplified so as to control key body functions. The Troponin protein complex is one such large multi-protein complex which is the switch used to control both heart and skeletal muscle contraction in the body. The Troponin complex responds to increasing cellular calcium levels, switching the muscle on at high calcium. ....Many key physiological processes are controlled by large, multi-protein complexes. These molecular machines ensure that signals transmitted in the body are correctly interpreted and amplified so as to control key body functions. The Troponin protein complex is one such large multi-protein complex which is the switch used to control both heart and skeletal muscle contraction in the body. The Troponin complex responds to increasing cellular calcium levels, switching the muscle on at high calcium. When calcium returns to its normal basal level, the Troponin complex switches the muscle off. Naturally occurring genetic errors can lead to the malfunction of the Troponin complex. This, in turn, can lead to severe and possibly fatal diseases of the heart and muscle systems. To gain an understanding of these molecular diseases, it is important to understand the structure, dynamics and function of the Troponin complex. This project will use a newly-developed magnetic resonance method to monitor changes in the Troponin structure as a function of calcium level. Each component of the Troponin complex will be labeled with magnetic tags, allowing the determination of both structure and dynamics of Troponin, both in solution and in active muscle fibres. The study will result in a molecular understanding of how the Troponin switch works. This will give great insight in how mutations result in cardiac and muscular diseases.Read moreRead less