TELEPHONE COUNSELLING FOR MAINTENANCE OF PHYSICAL ACTIVITY, WEIGHT LOSS And GLYCAEMIC CONTROL IN TYPE 2 DIABETES
Funder
National Health and Medical Research Council
Funding Amount
$1,285,894.00
Summary
Regular exercise, a healthy diet and weight loss are key to managing type 2 diabetes, yet these are major challenges for most people with diabetes. This study will evaluate the impact of a telephone counselling program to assist people with type 2 diabetes to exercise, eat a healthy diet and lose weight, with the goal of helping them to sustain these changes over the long-term. It is expected that these lifestyle changes will also result in improved blood glucose control and quality of life.
Understanding The Acute And Cumulative Metabolic Effects Of Prolonged Sitting In Adults
Funder
National Health and Medical Research Council
Funding Amount
$416,597.00
Summary
Sedentary behaviour (sitting time) has been linked to an increased risk of chronic illnesses, including type 2 diabetes and obesity, but recent evidence suggests that light-intensity activity (non-exercise activities of daily living) is associated with reduced risk. These studies will examine whether breaking up sitting time with frequent short periods of activity can overcome the negative effects of prolonged sitting on blood glucose and blood fats in overweight older adults.
A Behavioural Intervention For The Adoption & Maintenance Of Physical Activity In Type 2 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$334,955.00
Summary
For people with type 2 diabetes (T2DM) it is essential that blood glucose levels are managed well to reduce the risk of developing complications. Physical activity is essential for maintaining glucose levels because it helps make the muscles use glucose more effectively. In particular, being active through strength training not only improves blood glucose levels, but can be very effective for maintaining good physical functioning, which is known to be reduced by having T2DM. This study builds on ....For people with type 2 diabetes (T2DM) it is essential that blood glucose levels are managed well to reduce the risk of developing complications. Physical activity is essential for maintaining glucose levels because it helps make the muscles use glucose more effectively. In particular, being active through strength training not only improves blood glucose levels, but can be very effective for maintaining good physical functioning, which is known to be reduced by having T2DM. This study builds on our earlier research which demonstrated significantly improved blood glucose levels from a strength training program for older adults with T2DM. The strength training program is to be administered nationally in a research to practice trial (Lift for Life); however, the original research found that those who did not complete the program as it was intended (ie, poor adherence) did not show significant improvements in blood glucose levels. Furthermore, maintenance of strength training exercises after completion of the program was poor and resulted in return of blood glucose levels back to pre-starting levels. In people without diabetes, we have collected pilot data that shows that the use of behavioural strategies based on behavioural theories whereby each person's motivations and barriers are taken into consideration is more effective than the traditional one-treatment-fits-all approach. This study will evaluate the effectiveness of using behavioural strategies for improving adherence and maintenance to the Lift for Life strength training program (Enhanced L4L) for older adults with T2DM compared with the Standard L4L program. It will also follow-up participants 6 months later to determine the extent to which the changes in behaviour can be maintained. The study will provide information that will assist in the design, delivery and uptake of programs to improve treatment strategies in older adults with T2DM through the maintenance of healthier behaviours and lifestyles.Read moreRead less
Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
Transforming Microgrid to Virtual Power Plant –ICT Frameworks,Tools,Control. The project aims to enhance large scale renewable penetrations to national power grid by advancing control, optimization, and ancillary services of Virtual Power Plants (VPPs), considering different disruptive events including recent South Australian blackout. This project expects to create new control, frame communication architecture, develop plug and play type IoT enabled grid interfacing inverter, and optimize resou ....Transforming Microgrid to Virtual Power Plant –ICT Frameworks,Tools,Control. The project aims to enhance large scale renewable penetrations to national power grid by advancing control, optimization, and ancillary services of Virtual Power Plants (VPPs), considering different disruptive events including recent South Australian blackout. This project expects to create new control, frame communication architecture, develop plug and play type IoT enabled grid interfacing inverter, and optimize resource management for distributed VPPs. The anticipated benefits from this institutional level collaborations are that VPPs help in enhancing national power grid operations during normal and disruptive conditions when more renewables are connected and also secure benefits of consumers, prosumers, and grid operators.Read moreRead less
On-chip spectroscopy and hyperspectral imaging for remote environments. On-chip spectroscopy and hyperspectral imaging for remote environments. This project aims to investigate techniques and materials for building optical spectrometers based on micromachines, usable in portable ground-based and drone-mounted applications in remote environments. Optical spectroscopy is now an accepted technique for materials detection and analysis. The advent of low-cost drone aircraft makes the potential applic ....On-chip spectroscopy and hyperspectral imaging for remote environments. On-chip spectroscopy and hyperspectral imaging for remote environments. This project aims to investigate techniques and materials for building optical spectrometers based on micromachines, usable in portable ground-based and drone-mounted applications in remote environments. Optical spectroscopy is now an accepted technique for materials detection and analysis. The advent of low-cost drone aircraft makes the potential applications of spectroscopy in an imaging form immense. The project expects the resulting low-cost and highly portable technology will transform Australian industry, including securing Australia’s food supply by improving farming practices, aiding mineral exploration, and enhancing capabilities for monitoring Australia’s coastline.Read moreRead less
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC190100026
Funder
Australian Research Council
Funding Amount
$4,969,663.00
Summary
ARC Training Centre for Cell and Tissue Engineering Technologies. The ARC Training Centre for Cell and Tissue Engineering Technologies aims to provide training to create a highly skilled workforce for the tissue engineering and regenerative medicine sector and to enhance research performance and innovation in Australia through fundamental and applied research carried out in industry-led PhD projects. The research aims to address major aspects of the manufacturing and commercialisation pathway an ....ARC Training Centre for Cell and Tissue Engineering Technologies. The ARC Training Centre for Cell and Tissue Engineering Technologies aims to provide training to create a highly skilled workforce for the tissue engineering and regenerative medicine sector and to enhance research performance and innovation in Australia through fundamental and applied research carried out in industry-led PhD projects. The research aims to address major aspects of the manufacturing and commercialisation pathway and barriers faced by the sector, namely improving process efficiencies, enabling early-stage scale-up (cell/tissue) and development of the sector's supply chain. The knowledge created and research undertaken would help to accelerate commercialisation in regenerative medicine, tissue engineering and cell therapies.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC210100021
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre in Energy Technologies for Future Grids. The proposed Future Grids Training Centre will advance Australia’s transition to a clean energy future. It will address the complex and challenging issues currently limiting the growth of renewable energy through innovations that facilitate widespread integration of these resources into electricity grids while maintaining grid stability. The Centre will deliver the next generation of industry leaders and specialists in future grid tech ....ARC Training Centre in Energy Technologies for Future Grids. The proposed Future Grids Training Centre will advance Australia’s transition to a clean energy future. It will address the complex and challenging issues currently limiting the growth of renewable energy through innovations that facilitate widespread integration of these resources into electricity grids while maintaining grid stability. The Centre will deliver the next generation of industry leaders and specialists in future grid technologies for renewable energy generation, transmission and distribution, supported by renewable hydrogen energy storage and market driven customer responsiveness enabled by new information and communications technologies, to provide a more sustainable, reliable, secure and affordable electricity system.Read moreRead less